Journal
NANOSCALE
Volume 8, Issue 40, Pages 17440-17445Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr06115j
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Funding
- National Key Research and Development Plan of China [2016YFA0204300]
- National High Technology Research and Development Program (863 Program) of China [2014AA020507]
- National Natural Science Foundation of China [51573085]
- Tsinghua University Initiative Scientific Research Program [20131089191]
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A nature-inspired approach to encapsulate enzymes in spindle-like copper hydroxysulfate nanocrystals was developed by a biomimetic mineralization process. Several types of enzymes including glucose oxidase (GOx), horseradish peroxidase (HRP), Candida antarctica lipase B (CALB) and cytochrome c (Cyt c) were successfully encapsulated in copper hydroxysulfate nanocrystals quickly (within 1 hour) with maintained or even greatly enhanced catalytic efficiencies (k(cat)/K-M of Cyt c showed a 143-fold increase) and high stabilities, demonstrating the feasibility of utilizing copper hydroxysulfate nanocrystals as a novel type of nanocarrier for enzyme immobilization. In addition, by this approach, for the first time, we showed that an immobilized enzyme can be endowed with self-antibacterial activity by an inorganic component. This self-antibacterial performance together with the improved catalytic efficiencies and stabilities can greatly benefit the enzymatic catalysis in aqueous media and promote the future development of novel biosensors.
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