A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair

Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Biochemistry & Molecular Biology

Controlled Hydrolysis of Odorants Schiff Bases in Low-Molecular-Weight Gels

Gloria Nicastro et al.

Summary: This study reports the controlled hydrolysis of four Schiff bases that could be used in the fragrance industry. The results demonstrate the possibility of controlling the hydrolysis of Schiff bases in a gel environment, thus tuning the persistency of the fragrance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics

Dmitrii Iudin et al.

Summary: The increasing number of drug-resistant pathogenic bacteria poses a global health threat. This study developed hybrid core-shell nanoparticles as delivery systems to enhance the antimicrobial properties of polymyxins. The nanoparticles exhibited low cytotoxicity, antimicrobial activity, and showed a synergistic effect when combined with silver nanoparticles.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Yun Meng et al.

Summary: Bacteria and excessive inflammation are the main causes of non-healing wounds. This study proposes a boron-trapping strategy using reactive metal boride nanoparticles to prevent infection and excessive inflammation. The strategy enhances bacterial death and inhibits inflammation, promoting wound healing.

NATURE COMMUNICATIONS (2022)

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Article Materials Science, Biomaterials

Cell Infiltrative Inner Connected Porous Hydrogel Improves Neural Stem Cell Migration and Differentiation for Functional Repair of Spinal Cord Injury

Ming Shi et al.

Summary: This study prepared a porous GelMA scaffold with optimized inner porous structure and demonstrated that the porous hydrogel can promote neuron differentiation, enhance animal movement ability, and alleviate inflammation response and apoptosis. These findings suggest that the porous hydrogel is a promising scaffold for future stem cell delivery and material design in the treatment of spinal cord injury.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Review Oncology

Anti-inflammatory hydrogel dressings and skin wound healing

Can Huang et al.

Summary: Hydrogel dressings have shown promising potential in the biomedical field, particularly in promoting wound healing. In recent years, significant progress has been made in addressing excessive inflammation and promoting wound healing with hydrogel dressings. Excessive inflammation is a common issue in chronic wounds, hindering the repair process. Therefore, resolving excessive inflammation is crucial for effective wound healing.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Medicine, General & Internal

Chronic wounds

Vincent Falanga et al.

Summary: Chronic wounds are wounds that do not heal within an expected time frame due to prolonged dysregulated inflammation. Advances in understanding the cellular and molecular aspects of basic science and innovative treatment modalities have improved the management of chronic wounds. However, gaps still exist in scientific knowledge, highlighting the need for further research to enhance understanding of chronic wounds.

NATURE REVIEWS DISEASE PRIMERS (2022)

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Review Cell Biology

Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers

Jiawei Feng et al.

Summary: This review explores the pathological mechanisms of delayed wound healing in diabetic ulcers, revealing the potential association between ferroptosis and diabetic ulcer healing delay, and proposes new treatment strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Engineering, Biomedical

Promoting Re-epithelialization in an oxidative diabetic wound microenvironment using self-assembly of a ROS-responsive polymer and P311 peptide micelles

Rong Shi et al.

Summary: P311-loaded micelles synthesized by self-assembly have the ability to transform oxidative wound microenvironment into a proregenerative one and provide cues for epidermal cell migration, resulting in accelerated healing of diabetic wounds.

ACTA BIOMATERIALIA (2022)

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Article Biochemistry & Molecular Biology

Synthesis and characterization of protocatechuic acid grafted carboxymethyl chitosan with oxidized sodium alginate hydrogel through the Schiff's base reaction

Yujiao Yan et al.

Summary: The novel PCA-g-CMCS/OSA hydrogel developed in this study demonstrates superior antioxidant activity and potential in cell culture and biocompatibility. The hydrogel shows protective effects against oxidative damage and excellent swelling and biodegradability properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde-gelatin hydrogel

Resmi Rajalekshmi et al.

Summary: The development of a tissue-engineered construct for hepatic regeneration is challenging due to the lack of an optimum environment for hepatocyte growth. Injectable alginate dialdehyde-gelatin hydrogel incorporating fibrin was explored as a matrix for liver tissue engineering, showing promising support for the growth and function of HepG2 cells.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Targeted hot ion therapy of infected wound by glycol chitosan and polydopamine grafted Cu-SiO2 nanoparticles

Qing Xu et al.

Summary: This study developed multifunctional nanoparticles for combating drug-resistant bacteria and repairing infectious tissue. These nanoparticles showed high-efficiency, quick, and long-term antibacterial effects through near-infrared light-induced heating and copper ion release, as well as immune response promotion and stimulation of angiogenesis.

NANO TODAY (2021)

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Article Polymer Science

Gelatin Methacryloyl Hydrogels for the Localized Delivery of Cefazolin

Margaux Vigata et al.

Summary: Hydrogels are considered ideal for local drug delivery due to their tunability, with the newly developed GelMA-DDS showing excellent drug encapsulation efficiencies and tunable mechanical properties for the delivery of cefazolin against SSIs. The diffusive and proteolytic drug delivery of cefazolin showed burst release characteristics and dose-dependent efficacy against S. aureus, highlighting the potential of GelMA-DDS for the prophylaxis and treatment of SSIs.

POLYMERS (2021)

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Article Engineering, Environmental

Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Cheng Hu et al.

Summary: The study successfully overcame the challenges in healing chronic diabetic wounds, such as bacterial infections and difficulty in angiogenesis, by using a pH-responsive double-crosslinking hydrogel.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Yu Wang et al.

Summary: The study synthesized a dual-responsive hydrogel (pH and ROS) for drug release under inflammatory stimulation. This novel design retained dynamic functions of hydrogels and achieved sequential and on-demand drug delivery at diabetic-infected wound sites.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Engineering Bacteria-Activated Multifunctionalized Hydrogel for Promoting Diabetic Wound Healing

Yifei Lu et al.

Summary: This study presents a novel approach of using a delivery system comprising living Lactococcus to bioengineer the wound microenvironment and enhance angiogenesis in a highly dynamic-temporal manner, aiming to drive rapid healing in chronic wounds.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Hyaluronan/Diethylaminoethyl Chitosan Polyelectrolyte Complexes as Carriers for Improved Colistin Delivery

Natallia Dubashynskaya et al.

Summary: Improving antibiotic therapeutic characteristics by developing a CT delivery system based on HA and DEAECS was successful, resulting in a PEC carrier with good encapsulation and release properties without reducing the antimicrobial activity of CT.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Rational design of a new antibiotic class for drug-resistant infections

Thomas F. Durand-Reville et al.

Summary: The study presents a rational design strategy for developing new antibiotics to combat infections caused by drug-resistant Gram-negative pathogens. The inhibitors are able to overcome multiple mechanisms of resistance and show potential clinical efficacy against superbugs.

NATURE (2021)

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Article Engineering, Biomedical

Polymyxin B-Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy

Yejiao Shi et al.

Summary: Repurposing old antibiotics, such as polymyxin B, into a peptide hydrogel for targeted and sustained release shows promise in treating multidrug-resistant bacterial infections. The hydrogel demonstrates prolonged antimicrobial activities against Gram-negative bacteria and can be further enhanced with the incorporation of additional antibiotics, making it a versatile platform for combined antimicrobial therapies.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Immunology

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

Yali Gong et al.

Summary: This study compared the infection profile and antimicrobial resistance changes between burn intensive care unit (BICU) and burn common wards (BCW). The findings show that the types of pathogens and multidrug resistance patterns are significantly different between BICU and BCW. Over time, the gap in antimicrobial resistance between BICU and BCW has gradually narrowed.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

Snake extract-laden hemostatic bioadhesive gel cross-linked by visible light

Yicheng Guo et al.

Summary: The study introduces a novel visible light-induced blood-resistant hemostatic adhesive (HAD) that efficiently achieves hemostasis by activating and aggregating platelets. HAD demonstrates excellent hemostatic performance on liver incision and severed rat tail, significantly reducing blood loss.

SCIENCE ADVANCES (2021)

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Article Biotechnology & Applied Microbiology