Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-023-01947-7
Keywords
Chronic wound healing; Multidrug-resistant bacterial infection; Hydrogel; Anti-infection; Anti-inflammatory; PMB
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Suppressing MDR bacterial infections and excessive inflammation is crucial for treating chronic wounds. Therefore, it is desired to develop a microenvironment-responsive material with good biodegradability, drug-loading, anti-infection, and anti-inflammatory properties. However, using ordinary assembly remains a defect.
Suppressing persistent multidrug-resistant (MDR) bacterial infections and excessive inflammation is the key for treating chronic wounds. Therefore, developing a microenvironment-responsive material with good biodegradability, drug-loading, anti-infection, and anti-inflammatory properties is desired to boost the chronic wounds healing process; however, using ordinary assembly remains a defect. Herein, we propose a pH/enzyme dual-responsive polymyxin B (PMB) spatiotemporal-release hydrogel (GelMA/OSSA/PMB), namely, the amount of OSSA and PMB released from GelMA/OSSA/PMB was closely related the wound pH and the enzyme concentration changing. The GelMA/OSSA/PMB showed better biosafety than equivalent free PMB, owing to the controlled release of PMB, which helped kill planktonic bacteria and inhibit biofilm activity in vitro. In addition, the GelMA/OSSA/PMB exhibited excellent antibacterial and anti-inflammatory properties. A MDR Pseudomonas aeruginosa caused infection was effectively resolved by the GelMA/OSSA/PMB hydrogel in vivo, thereby significantly boosting wound closure during the inflammatory phase. Furthermore, GelMA/OSSA/PMB accelerated the sequential phases of wound repair.
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