Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12951-023-02007-w
Keywords
Zeolitic imidazolate framework-8; Biomimetic mineralization; Polycaprolactone; Melt electrowritten printing; Osteogenic differentiation; Bone regeneration
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In this study, it was discovered that ZIF-8 can induce the formation of large hydroxyapatite-like crystals when soaked directly in simulated body fluid. These crystals grew rapidly for two weeks, increasing in volume over 10-fold. It was found that ZIF-8 particles can undergo gradual collapse and re-nucleation, leading to improved biocompatibility and osteoinductivity of poly(ε-caprolactone) (PCL).
ZIF-8 may experience ion-responsive degradation in ionic solutions, which will change its initial architecture and restrict its direct biological use. Herein, we report an abnormal phenomenon in which ZIF-8 induces large hydroxyapatite-like crystals when soaked directly in simulated body fluid. These crystals grew rapidly continuously for two weeks, with the volume increasing by over 10 folds. According to Zn2+ release and novel XRD diffraction peak presence, ZIF-8 particles can probably show gradual collapse and became congregate through re-nucleation and competitive coordination. The phenomenon could be found on ZIF-8/PCL composite surface and printed ZIF-8/PCL scaffold surface. ZIF-8 enhanced PCL roughness through changing the surface topography, while obviously improving the in-vivo and in-vitro osteoinductivity and biocompatibility. The pro-biomineralization property can make ZIF-8 also applicable in polylactic acid-based biomaterials. In summary, this study demonstrates that ZIF-8 may play the role of a bioactive additive enabling the surface modification of synthetic polymers, indicating that it can be applied in in-situ bone regeneration.
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