4.7 Article

Biomimetic hypoxia-triggered RNAi nanomedicine for synergistically mediating chemo/radiotherapy of glioblastoma

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy

Hyung Shik Kim et al.

Summary: In this study, nanoconjugates composed of gold nanoparticles and photosensitizers were prepared. These nanoconjugates exhibit high heat dissipation and ROS generating capability. By incorporating lactoferrin onto the surface of the nanoconjugates, targeted therapy for GBM can be achieved, and the oral administration improves the bioavailability.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Review Biotechnology & Applied Microbiology

Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma

Danping Zhuang et al.

Summary: This review summarizes the recent advances in MRI contrast agents and dual-modal or triple-modal nanoprobes for glioblastoma (GBM) imaging, and discusses potential obstacles and prospects for future research and clinical translation of these contrast agents.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

Qiangqiang Zhao et al.

Summary: This study proposes a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), camouflaged by the cancer cell membrane (CCM), called CCM@MSNs-ISOIM. This nano-platform features immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility, and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy

Johan Karlsson et al.

Summary: This study introduces a novel strategy involving photocrosslinking of bioreducible nanoparticles to enhance the systemic delivery of RNA. The photocrosslinked bioreducible nanoparticles exhibit improved stability and efficient siRNA-mediated gene silencing effects in melanoma tumors, providing potential for advancing nucleic acid-based therapeutics delivery technologies.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

A tumor-activatable peptide supramolecular nanoplatform for the delivery of dual-gene targeted siRNAs for drug-resistant cancer treatment

Yahui Wu et al.

Summary: Combinatorial short interference RNA (siRNA) technology is utilized to silence multiple genes in cancer treatment. A tumor-activatable supramolecular nanoplatform is designed and synthesized to successfully deliver dual-gene targeted combinatorial siRNAs for effective inhibition of tumor cell growth and neovascularization in drug-resistant cancers.

NANOSCALE (2021)

Article Chemistry, Multidisciplinary

siRNA Nanoparticle Suppresses Drug-Resistant Gene and Prolongs Survival in an Orthotopic Glioblastoma Xenograft Mouse Model

Kui Wang et al.

Summary: The study introduces the development of iron oxide nanoparticles for targeted delivery of small interfering RNAs to suppress the TMZ-resistance gene in treating GBMs. This approach leads to increased apoptosis of GBM stem-like cells, reduced tumor growth, and significantly prolonged survival compared to conventional treatment with TMZ alone, offering promising outcomes for GBM patients.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo

Petro Zhupanyn et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Multidisciplinary Sciences

O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth

Hao Nie et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Yan Zou et al.

ADVANCED MATERIALS (2020)

Review Medicine, Research & Experimental

Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target for diagnosis and therapy

Qi Fu et al.

LIFE SCIENCES (2020)

Review Pharmacology & Pharmacy

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

Sei Yonezawa et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Biotechnology & Applied Microbiology

The current state and future directions of RNAi-based therapeutics

Ryan L. Setten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Nanoscience & Nanotechnology

Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy

Wei Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Chemistry, Multidisciplinary

Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours

Johan Karlsson et al.

NANOSCALE (2019)

Article Biochemistry & Molecular Biology

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

Yajuan Zhang et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Xiaoyue Chen et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

RNA interference-based therapy and its delivery systems

Xiuhui Chen et al.

CANCER AND METASTASIS REVIEWS (2018)

Article Gastroenterology & Hepatology

Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis

Hongli Hu et al.

HEPATOLOGY (2017)

Review Medicine, Research & Experimental

RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials

Eunice L. Lozada-Delgado et al.

LIFE SCIENCES (2017)

Review Oncology

Challenges and opportunities for siRNA-based cancer treatment

Tao Wang et al.

CANCER LETTERS (2017)

Article Chemistry, Multidisciplinary

Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Huiping Sun et al.

ADVANCED MATERIALS (2016)