Related references
Note: Only part of the references are listed.
Article
Pharmacology & Pharmacy
Xin Li et al.
Summary: To enhance the anti-metastasis effects of honokiol (HNK) on breast cancer, researchers designed cationic liposomes encapsulating HNK and modified their surface with negatively charged polysialic acid (PSA-Lip-HNK). In vitro experiments showed that PSA-Lip-HNK increased cellular uptake and cytotoxicity through the endocytosis pathway mediated by PSA and selectin receptors. In vivo experiments on tumor-bearing mice demonstrated that PSA-Lip-HNK effectively inhibited tumor growth and metastasis. Therefore, PSA-Lip-HNK provides a promising drug delivery approach for metastatic breast cancer therapy.
Article
Chemistry, Multidisciplinary
Ruoxi Zhao et al.
Summary: In this study, a BiVO4 artificial nanozyme is developed with adjustable vanadium vacancy for ultrasound enhanced piezoelectric/sonodynamic therapy. Under ultrasound excitation, the vanadium vacancy-rich BiVO4 nanosheets facilitate the generation of a large number of electrons, improving the yield of reactive oxygen species (ROS). The introduction of cationic vacancy can improve the sonodynamic effect and the V-v-r BiVO4 nanosheets have better enzyme catalytic and glutathione depletion activities, leading to increased intracellular oxidative stress. This triple amplification strategy of oxidative stress induced by ultrasound inhibits the growth of cancer cells.
Article
Pharmacology & Pharmacy
Ying Zhou et al.
Summary: Skin infection caused by bacterial proliferation in wounds is a major health issue. The abuse of antibiotics worldwide has made the battle against skin infection more difficult. Therefore, the development of new methods with different antibacterial mechanisms is urgently needed. In this study, ferric-loaded lipid nanoparticles (Fe-LNPs) were constructed, which effectively inhibited the growth of both Gram positive and negative strains, potentially through induction of ferroptosis-like cell death mechanisms. Fe-LNPs also showed effectiveness in inhibiting the proliferation of Staphylococcus aureus in a skin infection model and promoting wound healing. Fe-LNPs can be a powerful antibacterial formulation for future clinical application.
Review
Engineering, Biomedical
Zihao Wang et al.
Summary: Single-atom catalysts are atomically dispersed nanozymes with high atom utilization and excellent catalytic performance. However, undesired aggregation effect can occur during activation and reaction processes, requiring appropriate substrates to stabilize their catalytic activity.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Xiangyi Ren et al.
Summary: Nanozymes are a type of nanomaterials that mimic the activities of natural enzymes, and they have received great attention in the field of biomedicine due to their high stability and low cost. The enzyme-mimetic activities of nanozymes can be regulated by various factors, and they show great promise for biomedical applications. This review provides a comprehensive overview of nanozymes and their applications in biomedicine, discussing their mechanisms, applications, and future challenges.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Qiang Bai et al.
Summary: This study reports a novel nanozyme system, zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR), which exhibits unique piezocatalytic enzyme mimic activity. It effectively promotes the decomposition of hydrogen peroxide (H2O2) and generation of reactive oxygen species under ultrasound irradiation, resulting in almost 100% antibacterial efficacy against multidrug-resistant pathogens. Moreover, a piezoelectric activatable nanozyme-based skin patch is developed for rapid wound disinfection.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Lu Yao et al.
Summary: CQDs derived from chlorogenic acid (ChA) from coffee show promising potential as biocompatible nanozymes for anticancer therapeutics. In vivo experiments demonstrate that ChA CQDs not only significantly inhibit tumor growth but also activate systemic antitumor immune responses by recruiting immune cells.
Article
Pharmacology & Pharmacy
Zhian Chen et al.
Summary: The study developed a treatment platform based on PEG-PDA@Mn nanoparticles, which combined near-infrared-triggered photothermal therapy (PTT) with Fenton-like reaction-based chemodynamic therapy (CDT) for gastric cancer treatment. The platform also exhibited anti-tumor effects under MRI guidance.
Article
Chemistry, Medicinal
Xiaoguang Zhu et al.
Summary: Nanozymes, as emerging nanomaterials with enzyme-like activity, show great potential for integrating diagnosis and therapy in the tumor microenvironment (TME). By combining multi-enzyme-like activities, multi-modal imaging methods, and multifunctional therapy platforms, nanozymes offer significant advantages for effective therapy. This review summarizes the advancements of smart nanozymes responsive to various triggers in TME-based theranostics, while also discussing the obstacles and difficulties in their clinical applications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Hailong Tian et al.
Summary: A novel cascaded copper-based metal-organic framework therapeutic nanocatalyst was reported for amplified hepatocellular carcinoma therapy by integrating a COX-2 inhibitor and a chemotherapeutic agent to trigger ferroptosis-mediated therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jiancheng Zhang et al.
Summary: This study synthesized sulfur-doped graphdiyne nanosheets and demonstrated their impressive peroxidase-like activities and piezoelectric properties. Kinetic investigations and DFT calculations revealed the mechanism of piezoelectric effect on promoting peroxidase-like activity. The results showed the great potential of sulfur-doped graphdiyne in applications, especially in wastewater treatment.
Article
Nanoscience & Nanotechnology
Chaohui Zhang et al.
Summary: This article reports a metal-free ferroptosis-apoptosis inducer based on boron and nitrogen codoped graphdiyne, which has efficient GSH depletion capability and induces ferroptosis by deactivating GPX4 and apoptosis by downregulating Bcl2. The high catalytic activity of the inducer is explained by both experiments and DFT calculations, and a unique Bi-Bi mechanism is discovered.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Yunchao Zhao et al.
Summary: This study demonstrates the use of a Cu2-xO-BaTiO3 piezoelectric heterostructure as a sonosensitizer and chemodynamic agent for enhanced cancer therapy through ultrasound irradiation.
Article
Engineering, Biomedical
Xiaoxiong Zhao et al.
Summary: This study demonstrates that surface engineering of ginsenoside Rg3 dramatically alters the distribution and enrichment of nanocatalysts in tumor, leading to improved efficacy and reduced toxicity. The Rg3-sheltered dynamic nanocatalysts can activate ferroptosis and apoptosis simultaneously, resulting in significant anticancer effects.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Yaqian He et al.
Summary: This study focuses on the use of piezoelectric catalytic water splitting to reduce tumor interstitial fluid pressure and improve drug delivery, leading to enhanced treatment of solid malignant tumors.
Article
Chemistry, Analytical
Hetong Qi et al.
Summary: In this study, a dual-site carbon nanozyme B-GDY was prepared with enhanced peroxidase-like activity. By acidic oxidation treatment and thermal annealing, boron and ketonic carbonyl groups were introduced into GDY, resulting in increased activity of B-GDY. Experimental and theoretical studies revealed that the high activity of B-GDY was attributed to its dual active sites, facilitating the adsorption and decomposition of H2O2. Moreover, B-GDY was successfully applied for colorimetric detection of glucose.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Fabio Franca Vieira E. Silva et al.
Summary: This study reviews the expression changes of Caspase 3 and Cleaved Caspase 3 in oral premalignant disorders and head and neck cancer. The results show similar expression of Caspase 3 in head and neck cancer compared to oral premalignant disorders, while Cleaved Caspase 3 is increased in head and neck cancer. The expression of Caspase 3 does not influence the prognosis of patients with head and neck cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Xiaodan Li et al.
Summary: Graphdiyne (GDY) is a two-dimensional carbon nanomaterial with specific configurations of sp and sp(2) carbon atoms, which has made significant progress in the field of biomedical applications. The unique properties and performance of GDY have led to its emergence in life sciences, presenting new opportunities for biomedical research. Challenges facing GDY in future biomedical applications are also discussed.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Plant Sciences
Haoliang Ke et al.
Summary: The study found that WMN effectively inhibits the growth of 4T1-luc2 breast cancer xenografts in mice and promotes the apoptosis of breast cancer cells by upregulating caspase-3 expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Engineering, Environmental
Binesh Unnikrishnan et al.
Summary: Large-scale mining and manufacturing industries have caused severe heavy metal ion pollution, necessitating rapid detection of toxic metal ions. Metal nanozyme-based assays offer portability, simplicity, and high sensitivity, allowing for quick screening on the spot, especially in remote areas.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Engineering, Biomedical
Qian Wang et al.
Summary: Nanozymes are nanomaterials with enzyme-like characteristics that can overcome the limitations of natural enzymes in enzymatic therapy. They have various activities that can either protect cells or kill harmful cells, showing great potential in medical applications.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xuantong Zhou et al.
Summary: Radioresistance poses a significant challenge in clinical treatments, attributed to factors such as hypoxia in the tumor microenvironment, antioxidant systems in cancer cells, and upregulation of DNA repair proteins. A novel strategy involving GDY-CeO2 nanocomposites and miR181a shows promise in overcoming radioresistance and enhancing therapeutic efficacy in ESCC patients by mitigating hypoxia, promoting DNA damage, and facilitating personalized treatment.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Kai Niu et al.
Summary: Enzymatic biosensors based on nitrogen-doped graphdiyne exhibit high sensitivity, excellent reproducibility, and stability, showing great potential for rapid detection of environmental pollutants. The nitrogen doping enhances electrical conductivity and substance adsorption, contributing to significantly improved biosensing performance.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Lili Teng et al.
Summary: A novel nanozyme with oxidase-like activity was developed for acid-induced cancer therapy, utilizing ratiometric near-infrared fluorescence-photoacoustic molecular imaging to report its catalytic activity. The nanozyme showed excellent anticancer efficacy in the tumor microenvironment, and the ratiometric signals provided a new approach for predicting its efficacy in living systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Pharmacology & Pharmacy
Huilin Liu et al.
Summary: This study demonstrated that PDMs + US can serve as molecular imaging agents for early diagnosis of B cell lymphomas and an effective targeted drug delivery system, inhibiting the growth of CD20+ B cell lymphomas.
Review
Biochemistry & Molecular Biology
Hong-fa Yan et al.
Summary: Ferroptosis is a form of cell death that is iron-dependent and involves accumulation of lethal lipid species from lipid peroxidation. This review discusses the regulatory mechanisms of ferroptosis and its connections with iron, lipid, and cysteine metabolism pathways. Additionally, it explores the role of ferroptosis in diseases such as cancer, ischemia/reperfusion, Alzheimer's disease, and Parkinson's disease, and evaluates the potential therapeutic applications of ferroptosis inhibitors in clinical settings.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Pinghua Ling et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Oncology
Yanwei Su et al.
Article
Chemistry, Multidisciplinary
Sobira Gharehzadeh Shirazi et al.
Article
Chemistry, Multidisciplinary
Piao Zhu et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Huan Min et al.
ADVANCED MATERIALS
(2020)
Review
Pharmacology & Pharmacy
Yangmin Qiu et al.
PHARMACOLOGICAL RESEARCH
(2020)
Review
Chemistry, Multidisciplinary
Xiaonan Kan et al.
Article
Pharmacology & Pharmacy
Xiaoying Zhou et al.
Review
Chemistry, Multidisciplinary
Yanyan Huang et al.
Article
Chemistry, Multidisciplinary
Wei Jiang et al.
Article
Chemistry, Multidisciplinary
Hui Wang et al.
ADVANCED MATERIALS
(2019)
Review
Chemistry, Multidisciplinary
Dawei Jiang et al.
CHEMICAL SOCIETY REVIEWS
(2019)
Article
Chemistry, Multidisciplinary
Kangqiang Qiu et al.
CHEMICAL COMMUNICATIONS
(2018)
Article
Nanoscience & Nanotechnology
Shengliang Zhang et al.
ACS APPLIED MATERIALS & INTERFACES
(2016)