Journal
NANOSCALE
Volume 8, Issue 8, Pages 4727-4732Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr08278a
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Funding
- NSFC [21527810, 21190041, 21307029, 21221003]
- National Key Basic Research Program [2011CB911000]
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Graphitic C3N4 (g-C3N4) nanosheets provide an attractive option for bioprobes and bioimaging applications. Utilizing highly fluorescent and water-dispersible ultrathin g-C3N4 nanosheets, a highly sensitive, selective and label-free biosensor has been developed for ALP detection for the first time. The developed approach utilizes a natural substrate of ALP in biological systems and thus affords very high catalytic efficiency. This novel biosensor is demonstrated to enable quantitative analysis of ALP in a wide range from 0.1 to 1000 U L-1 with a low detection limit of 0.08 U L-1, which is among the most sensitive assays for ALP. It is expected that the developed method may provide a low-cost, convenient, rapid and highly sensitive platform for ALP-based clinical diagnostics and biomedical applications.
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