4.8 Article

Hydrophilic GO/Fe3O4/Au/PEG nanocomposites for highly selective enrichment of glycopeptides

Journal

NANOSCALE
Volume 8, Issue 9, Pages 4894-4897

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr08126b

Keywords

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Funding

  1. National Nature Science Foundation [21190043, 21235005, 91543201]
  2. National Basic Research Program of China [2012CB910601, 2013CB911201]
  3. Creative Research Group Project by NSFC [21321064]

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GO/Fe3O4/Au/PEG nanocomposites were synthesized via bonding gold nanoparticles on magnetic graphene oxide using polyethylenimine as the reducing and immobilizing reagent, followed by thiol-terminal polyethylene glycol immobilization. With the use of this nanocomposite, 255 glycopeptides, mapped to 127 different glycoproteins, were identified from human serum, demonstrating its great potential for glycosylation analysis.

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