4.8 Article

Single-layer MoS2 nanosheet grafted upconversion nanoparticles for near-infrared fluorescence imaging-guided deep tissue cancer phototherapy

Journal

NANOSCALE
Volume 8, Issue 15, Pages 7861-7865

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr00150e

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Funding

  1. Ministry of Education of Singapore [ARC 22/13]
  2. National Medical Research Council of Singapore
  3. SingHealth Foundation

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A multifunctional nanostructure is prepared by covalently grafting upconversion nanoparticles (UCNPs) with chitosan functionalized MoS2 (MoS2-CS) and folic acid (FA) and then loading phthalocyanine (ZnPc) on the surface of MoS2, which integrates photodynamic therapy (PDT) with photothermal therapy (PTT) and upconversion luminescence imaging into one system for enhanced antitumor efficiency.

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