Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function

ObjectiveThis study aimed to assess the effect of 1,3-propanediol at different concentrations (5%, 10%, or 15%), either applied alone or in combination with butylene glycol (BG) (5%) and/or glycerol (5%), on skin hydration and skin barrier function. The measurements were conducted using capacitance to determine skin hydration and trans epidermal water loss (TEWL) rates to evaluate skin barrier function.MethodsA total of 30 healthy female subjects participated in the study. Capacitance and TEWL measurements were conducted at multiple time points, including before application and at 15 min, 2 and 8 h after the humectants were applied to the forearms of the subjects. All the subjects provided written informed consent.ResultsThe 1,3-propanediol in all concentrations and in all combinations (with BG and/or glycerol) increased skin hydration and improved skin barrier function 15 min, 2 and 8 h after application. Glycerol increased the hydration performance of 1,3-propanediol. The application of 1,3-propanediol at a concentration of 15%, either alone or in combination with other humectants, reduced the TEWL to a greater extent than lower concentrations of 1,3-propanediol. Furthermore, the addition of glycerol to 1,3-propanediol 15% improved the skin barrier and reduced TEWL when compared with 1,3-propanediol alone and with the combination of 1,3-propanediol + BG.ConclusionThe humectants significantly improved skin hydration and reduced TEWL throughout the 8-h time course. The increase in 1,3-propanediol concentration, as well as its combination with glycerol, provided a greater benefit to the skin, improving both hydration and the skin barrier function. OBJECTIFCette etude visait a evaluer l'effet sur l'hydratation de la peau et la fonction de barriere cutanee du 1,3-propanediol a differentes concentrations (5 %, 10 % ou 15 %), applique seul ou en association avec du butylene glycol (5 %) et/ou du glycerol (5 %). Les mesures ont ete effectuees a l'aide de la capacitance pour determiner l'hydratation de la peau et les taux de perte d'eau transepidermique (Trans Epidermal Water Loss, TEWL) pour evaluer la fonction de barriere cutanee.Au total, 30 sujets de sexe feminin en bonne sante ont participe a l'etude. Les mesures de la capacitance et de la TEWL ont ete effectuees a plusieurs moments, y compris avant l'application, 15 minutes, 2 heures et 8 heures apres l'application des produits humectant sur les avant-bras des sujets. Tous les sujets ont fourni un consentement eclaire ecrit.ReSULTATSLe 1,3-propanediol, a toutes les concentrations et dans toutes les associations (avec le butylene glycol et/ou le glycerol), a augmente l'hydratation de la peau et ameliore la fonction de barriere cutanee a 15 minutes, 2 heures et 8 heures apres l'application. Le glycerol a augmente les performances d'hydratation du 1,3-propanediol. L'application de 1,3-propanediol a une concentration de 15 %, seul ou en association avec d'autres produits humectant, a reduit la TEWL dans une plus grande mesure que des concentrations inferieures de 1,3-propanediol. En outre, l'ajout de glycerol au 1,3-propanediol 15 % a ameliore la barriere cutanee et reduit la TEWL par rapport au 1,3-propanediol seul et a l'association 1,3-propanediol + butylene glycol.Les produits humectant ont significativement ameliore l'hydratation de la peau et reduit la TEWL tout au long des 8 heures. L'augmentation de la concentration de 1,3-propanediol, ainsi que son association avec le glycerol, ont apporte un plus grand benefice a la peau, ameliorant a la fois l'hydratation et la fonction de barriere cutanee. In this original paper we demonstrated that the increase in 1,3-propanediol concentration, as well as its combination with glycerol, provided a greater benefit to the skin, improving both hydration and the skin barrier function.image

Automated summary

This study demonstrates that the increase in 1,3-propanediol concentration, as well as its combination with glycerol, provides a greater benefit to the skin, improving both hydration and the skin barrier function.