Journal
NANOSCALE
Volume 8, Issue 13, Pages 7094-7104Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr08878j
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Funding
- Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme [PIIF-GA-2011-298821]
- MIUR [PRIN 2012SK7ASN]
- AIRC [IG 14565]
- CIRCMSB
- Compagnia di San Paolo
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A novel fluorescein/Gd-DOTAGA containing nanoprobe for the visualization of tumors by optical and Magnetic Resonance Imaging (MRI) is reported herein. It is based on the functionalization of the surface of small mesoporous silica nanoparticles (MSNs) (similar to 30 nm) with the arginine-glycine-aspartic (RGD) moieties, which are known to target alpha(v)beta(3) integrin receptors overexpressed in several tumor cells. The obtained nanoprobe (Gd-MSNs-RGD) displays good stability, tolerability and high relaxivity (37.6 mM(-1) s(-1) at 21.5 MHz). After a preliminary evaluation of their cytotoxicity and targeting capability toward U87MG cells by in vitro fluorescence and MR imaging, the nanoprobes were tested in vivo by T-1-weighted MR imaging of xenografted murine tumor models. The obtained results demonstrated that the Gd-MSNs-RGD nanoprobes are good reporters both in vitro and in vivo for the MR-visualization of tumor cells overexpressing alpha(v)beta(3) integrin receptors.
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