☆ 4.6 Review

Roles of bacterial extracellular vesicles in systemic diseases

FRONTIERS IN MICROBIOLOGY (2023)

Related references

Note: Only part of the references are listed.
Article Cell Biology

Faeces-derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases

Lionel Fizanne et al.

Summary: The study investigates the role of fEVs and cEVs in liver diseases such as NAFLD and NASH. NASH-fEVs were found to have deleterious effects, increasing intestinal permeability and reducing expression of tight junction proteins through the involvement of nmMLCK and lipopolysaccharide pathways.

JOURNAL OF EXTRACELLULAR VESICLES (2023)

Add to Collection
Article Microbiology

Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis

Ruyi Fan et al.

Summary: The role of Porphyromonas gingivalis outer membrane vesicles (OMVs) in the development of periodontitis is elucidated, with sRNA45033 targeting CBX5 and regulating the methylation of p53 DNA, apoptosis, and host-pathogen interaction. These findings provide insight into the immunological relevance and bacterial virulence of P. gingivalis OMVs in periodontitis development.

MICROBIOLOGY SPECTRUM (2023)

Add to Collection
Article Multidisciplinary Sciences

Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis

Xinyue Wang et al.

Summary: Outer membrane vesicles (OMVs) released by Akkermansia muciniphila can restore gut microbiota balance, stimulate mucosal immunoglobulin A response, and maintain intestinal barrier integrity by entering intestinal epithelial cells. Transplanting gut microbiota-derived OMVs can alleviate colitis and enhance anti-PD-1 therapy against colorectal cancer. This study highlights the important role of gut microbiota-derived OMVs in intestinal ecology and provides a new target for disease intervention and treatment.

SCIENCE ADVANCES (2023)

Add to Collection
Article Cell Biology

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua Xie et al.

Summary: The gut microbiota and its interaction with pathogens like Helicobacter pylori play a significant role in the development of Alzheimer's disease, with outer membrane vesicles acting as important carriers of virulence factors.

JOURNAL OF EXTRACELLULAR VESICLES (2023)

Add to Collection
Article Microbiology

Murine Norovirus Interaction with Enterobacter cloacae Leads to Changes in Membrane Stability and Packaging of Lipid and Metabolite Vesicle Content

Chanel A. Mosby et al.

Summary: Outer membrane vesicles (OMVs) serve as a means of communication for Gram-negative bacteria. Interaction with norovirus induces changes in OMV content, particularly in lipid accumulation and metabolite content, which may be linked to a shift in the mechanism of vesicle biogenesis.

MICROBIOLOGY SPECTRUM (2023)

Add to Collection
Article Medicine, Research & Experimental

Outer membrane vesicles derived from gut microbiota mediate tubulointerstitial inflammation: a potential new mechanism for diabetic kidney disease

Pei Pei Chen et al.

Summary: This study investigates the role of gut microbiota-derived outer membrane vesicles (OMVs) in tubulointerstitial inflammation in diabetic kidney disease (DKD). It was found that gut microbiota mediates tubulointerstitial inflammation in DKD, and that gut microbiota-derived OMVs induce cellular inflammation and renal tubulointerstitial injury through the activation of the caspase-11 pathway.

THERANOSTICS (2023)

Add to Collection
Article Neurosciences

An Investigation into the Effects of Outer Membrane Vesicles and Lipopolysaccharide of Porphyromonas gingivalis on Blood-Brain Barrier Integrity, Permeability, and Disruption of Scaffolding Proteins in a Human in vitro Model

Anna Barlach Pritchard et al.

Summary: This study utilized a human in vitro BBB model to evaluate the effects of P. gingivalis virulence factors LPS and OMVs on the neurovascular unit of the BBB. The results showed that the application of P. gingivalis LPS and OMVs weakened the integrity of the BBB.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Add to Collection
Article Neurosciences

Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice

Juli Choi et al.

Summary: Chronic stress leads to changes in gut microbiota composition, which is related to depressive behavior. The study finds that certain probiotics can ameliorate stress-induced depressive-like behavior by restoring the changes in neurotrophic factors in the hippocampus.

MOLECULAR NEUROBIOLOGY (2022)

Add to Collection
Article Multidisciplinary Sciences

Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice

Hong Gao et al.

Summary: Obesity is associated with increased gut permeability, which leads to the leakage of microbial DNA into pancreatic beta-cells and promotes obesity-associated islet inflammation. Various microbial products leaked from the gut exacerbate tissue inflammation and metabolic disorders in obesity. Vsig4+ macrophages prevent the infiltration of bacteria and their products into host tissues, but their role in the communication between microbiota and beta cells in the pathogenesis of obesity-associated islet abnormalities is unclear.

NATURE COMMUNICATIONS (2022)

Add to Collection
Article Nutrition & Dietetics

Modulation of Dendritic Cells by Microbiota Extracellular Vesicles Influences the Cytokine Profile and Exosome Cargo

Natalia Diaz-Garrido et al.

Summary: This study aimed to understand the mechanisms of extracellular vesicles (BEVs) in driving specific immune responses. The production of cytokines and exosomes by dendritic cells (DCs) challenged with BEVs from different strains of E. coli was analyzed. The results showed that the strains had differential effects on the production of specific cytokines and the composition of immune-related miRNA in the exosomes.

NUTRIENTS (2022)

Add to Collection
Article Cardiac & Cardiovascular Systems

Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice

Hong Gao et al.

Summary: Obesity leads to the leakage of gut microbial DNA into the bloodstream and infiltration into the adrenal glands, causing microbial DNA enrichment. The decrease of CRIg+ macrophages is associated with obesity-related adrenomedullary abnormalities, and gut microbial DNA promotes inflammatory responses and norepinephrine production.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Add to Collection
Article Immunology

Proteus mirabilis Vesicles Induce Mitochondrial Apoptosis by Regulating miR96-5p/Abca1 to Inhibit Osteoclastogenesis and Bone Loss

Tingting Wang et al.

Summary: Outer-membrane vesicles (OMVs) from Proteus mirabilis (P.M) were found to inhibit osteoclast formation and bone resorption by downregulating miR-96-5p, leading to mitochondria-dependent apoptosis and providing protection to the bone.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection
Article Cell Biology

Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease

Lejla Gul et al.

Summary: The gastrointestinal tract houses a complex microbial community that plays a crucial role in maintaining gut health. This study investigates the interactions between bacterial extracellular vesicles (BEVs) released by a gut commensal bacterium and host immune cells, revealing that the communication between BEVs and the host is influenced by both cell type and health status. The findings provide insights into potential BEV-based therapies for treating inflammatory bowel disease.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Add to Collection
Article Cell Biology

Interaction with mammalian enteric viruses alters outer membrane vesicle production and content by commensal bacteria

Chanel A. Mosby et al.

Summary: This article demonstrates for the first time that enteric viruses can alter gene expression and phenotype of commensal bacteria, leading to increased production of smaller outer membrane vesicles. The interaction between viruses and bacteria may have broad implications.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Outer Membrane Vesicles Secreted by Helicobacter pylori Transmitting Gastric Pathogenic Virulence Factors

Sisi Wei et al.

Summary: This study characterized H. pylori OMVs and analyzed their impact on gastric epithelial cells through proteomic technology. The results showed significant alterations in inflammatory and cancer signaling pathways induced by OMVs in host cells, suggesting a potential mechanism for H. pylori pathogenicity.

ACS OMEGA (2022)

Add to Collection
Article Physiology

Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis

Zhenlong Luo et al.

Summary: The development of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis is associated with the accumulation of microbial DNA and liver cell abnormalities.

ACTA PHYSIOLOGICA (2022)

Add to Collection
Article Immunology

Modulation of outer membrane vesicle-based immune responses by cathelicidins

Melanie D. Balhuizen et al.

Summary: Antibiotic resistance is increasing, and bacterial vaccines, such as outer membrane vesicles (OMVs) produced by Gram-negative bacteria, can be used to prevent resistance development. Host defense peptides (HDPs), specifically cathelicidins, have been found to modulate immune responses by interacting with OMVs and neutralizing LPS-induced TLR4 activation. Additionally, TLR2, 4, 5, and 9 play a role in macrophage stimulation by OMVs.

VACCINE (2022)

Add to Collection
Article Multidisciplinary Sciences

Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis

Chun-Yuan Chen et al.

Summary: This study demonstrates that cohousing with healthy mice or colonization with GM from normal mice attenuates GC-induced ONFH. Oral supplementation of L. animalis mitigates GC-induced ONFH by increasing angiogenesis, augmenting osteogenesis, and reducing cell apoptosis. The transfer of bacterial EVs is involved in protecting the femoral head, and the loss of L. animalis and its EVs is associated with the development of GC-induced ONFH.

SCIENCE ADVANCES (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Collaborative Action of Microglia and Astrocytes Mediates Neutrophil Recruitment to the CNS to Defend against Escherichia coli K1 Infection

Peng Liu et al.

Summary: Microglia and astrocytes are activated in response to Escherichia coli K1 infection, leading to neutrophil recruitment to the central nervous system. Microglial activation results in the release of TNF-alpha, which activates astrocytes to produce CXCL1. Neutrophils primarily respond to CXCL1 released by astrocytes through CXCR2. The recognition of E. coli K1 by microglia is prevented by the K1 capsule, and outer membrane vesicles are sufficient to induce microglial activation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Microbiology

Extracellular vesicles produced by the human gut commensal bacterium Bacteroides thetaiotaomicron elicit anti-inflammatory responses from innate immune cells

Sonia Fonseca et al.

Summary: This study confirms the anti-inflammatory and immunomodulatory properties of bacterial extracellular vesicles (BEVs) produced by Bacteroides thetaiotaomicron (Bt BEVs), a prominent gut commensal bacterium, and identifies the molecular mechanisms underlying their interaction with innate immune cells. Bt BEVs can alleviate intestinal inflammation and improve the survival rate of mice with colitis. These effects are attributed to the upregulation of IL-10 production and the induction of epigenetic reprogramming in immune cells.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection
Article Immunology

Effects of Exosomes Derived From Helicobacter pylori Outer Membrane Vesicle-Infected Hepatocytes on Hepatic Stellate Cell Activation and Liver Fibrosis Induction

Masoumeh Ebadi Zahmatkesh et al.

Summary: Helicobacter pylori infection may alter hepatocyte-derived exosomes and contribute to hepatic stellate cell activation and liver fibrosis progression.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Add to Collection
Article Immunology

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

Ting Gong et al.

Summary: This study found that the outer membrane vesicles of Porphyromonas gingivalis (Pg OMVs) can cause memory and learning impairments in elderly mice, damage the blood-brain barrier, activate neuroinflammatory responses, promote phosphorylation of Tau protein, and trigger NLRP3 inflammasome. These findings suggest that Pg OMVs play an important role in the development of Alzheimer's disease-like pathology induced by Porphyromonas gingivalis, and the activation of NLRP3 inflammasome may be one possible mechanism.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Porphyromonas gingivalis outer membrane vesicles in cerebral ventricles activate microglia in mice

Kayo Yoshida et al.

Summary: This study demonstrates that outer membrane vesicles (OMVs) of Porphyromonas gingivalis (Pg) can translocate to the brain and induce neuroinflammation by activating microglia. This finding contributes to a better understanding of the role of periodontal diseases in neurodegenerative conditions such as Alzheimer's disease (AD).

ORAL DISEASES (2022)

Add to Collection
Article Multidisciplinary Sciences

Effects of extracellular vesicles derived from oral bacteria on osteoclast differentiation and activation

Hyun Young Kim et al.

Summary: Bacterial extracellular vesicles (EVs) derived from periodontal pathogens and oral commensal have osteoclastogenic activity through Toll-like receptor 2 (TLR2) activation.

SCIENTIFIC REPORTS (2022)

Add to Collection
Article Biology

Visualizing extracellular vesicle biogenesis in gram-positive bacteria using super-resolution microscopy

Dokyung Jeong et al.

Summary: Researchers used super-resolution microscopy to reveal the ultrastructural organization of EVs produced by gram-positive bacteria and proposed three major mechanisms of EV biogenesis. These findings highlight the significant role of cell wall degradation in regulating EV formation.

BMC BIOLOGY (2022)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus

Marines du Teil Espina et al.

Summary: Staphylococcus aureus is a bacterial pathogen that causes infectious diseases, and Porphyromonas gingivalis is an oral bacterial pathogen. Certain components of P. gingivalis can promote the aggregation and internalization of S. aureus, potentially impacting the association between RA and SAB.

FRONTIERS IN ORAL HEALTH (2022)

Add to Collection
Review Immunology

Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer's disease

Ah-Mee Park et al.

Summary: Helicobacter pylori infection has an impact on the central nervous system, potentially leading to increased prevalence of Alzheimer's disease through the release of outer membrane vesicles and induction of neuroinflammation.

INFLAMMATION AND REGENERATION (2022)

Add to Collection
Article Microbiology

Outer Membrane Vesicles From Fusobacterium nucleatum Switch M0-Like Macrophages Toward the M1 Phenotype to Destroy Periodontal Tissues in Mice

Gang Chen et al.

Summary: Fusobacterium nucleatum outer membrane vesicles (F. nucleatum OMVs) were found to aggravate periodontitis, alveolar bone loss, and the number of osteoclasts. F. nucleatum OMVs promoted the polarization of macrophages towards the proinflammatory M1 phenotype, and the inflammatory environment further intensified the toxicity of F. nucleatum OMVs on gingival fibroblasts (MGFs).

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Exposure to extracellular vesicles from Pseudomonas aeruginosa result in loss of DNA methylation at enhancer and DNase hypersensitive site regions in lung macrophages

Min Kyung Lee et al.

Summary: P. aeruginosa extracellular vesicles alter DNA methylation patterns of human lung macrophages, leading to hypomethylation of 1,185 CpG sites. Changes in DNA methylation are associated with genes such as AXL, CFB, and CCL23, affecting gene expression. This infection model demonstrates how bacterial extracellular vesicles can modulate host DNA methylation, subsequently impacting gene expression and cellular processes.

EPIGENETICS (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Detection of Bacterial Membrane Vesicles by NOD-Like Receptors

Ella L. Johnston et al.

Summary: BMVs produced by both Gram-negative and Gram-positive bacteria contain immune stimulating molecules that can modulate host immune response through NLR-dependent mechanisms. Commensal derived BMVs are believed to shape immunity and maintain gut homeostasis, highlighting their roles in limiting inflammatory diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Biotechnology & Applied Microbiology

Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice

Fatemeh Ashrafian et al.

Summary: The study showed that pasteurized A. muciniphila and its EVs have preventive effects on HFD-induced obesity, with more noticeable effects than its active form. These treatments also inhibited inflammation and gene expression changes related to lipid metabolism caused by HFD, indicating a potential role in regulating metabolic functions to prevent obesity.

MICROBIAL CELL FACTORIES (2021)

Add to Collection
Article Gastroenterology & Hepatology

CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance

Zhenlong Luo et al.

Summary: Liver CRIg(+) macrophages play a critical role in filtering microbiota-derived products from the bloodstream. Obesity results in a marked reduction of CRIg(+) macrophage population, leading to the spread of microbial DNA throughout the body, exacerbating tissue inflammation and metabolic disorders.

GASTROENTEROLOGY (2021)

Add to Collection
Article Microbiology

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

Melinda A. Engevik et al.

Summary: The study demonstrates that Fusobacterium nucleatum can promote intestinal inflammation by activating Toll-like receptor 4 and NF-KB, leading to disruption of colonic architecture, immune cell infiltration, and increased levels of proinflammatory cytokines. The findings suggest a potential mechanism by which F. nucleatum contributes to intestinal inflammation in the context of a depleted gut microbiome.

MBIO (2021)

Add to Collection
Review Immunology

Host immunity and cellular responses to bacterial outer membrane vesicles

Varnesh Tiku et al.

Summary: Outer membrane vesicles (OMVs) produced by Gram-negative bacteria play crucial roles in various aspects of bacterial physiology and their interaction with vertebrate host cells. They are important for bacterial colonization, delivery of virulence factors, and disease pathogenesis. OMVs also help bacteria modulate host immune responses, aiding in their evasion of host immunity.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection
Review Immunology

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

Zhiying Zhang et al.

Summary: Periodontal disease is a chronic infectious disease associated with various systemic diseases, with P. gingivalis as the key pathogen producing OMVs that play an important role in disease pathogenesis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection
Review Microbiology

Outer Membrane Vesicles of Gram-Negative Bacteria: An Outlook on Biogenesis

Eric Daniel Avila-Calderon et al.

Summary: OMVs from Gram-negative bacteria were first described over 50 years ago, but the molecular mechanisms involved in their biogenesis have only been studied in recent decades. The current knowledge of OMV biogenesis and release mechanisms is incomplete, with recent studies focusing on various cellular components.

FRONTIERS IN MICROBIOLOGY (2021)

Add to Collection
Article Agriculture, Dairy & Animal Science

Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune homeostasis against lipopolysaccharide-induced inflammatory responses in broilers

Rujiu Hu et al.

Summary: L. reuteri BBC3-derived EVs (LrEVs) play a regulatory role in attenuating LPS-induced inflammation in a chicken model. They improve growth performance, reduce mortality, and decrease intestinal injury. LrEVs suppress pro-inflammatory gene expression and enhance anti-inflammatory gene expression in the jejunum, indicating their potential immunoregulatory effects.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength

Jiang-Hua Liu et al.

Summary: Recent studies have shown that gut microbiota from children can prevent decreases in bone mass and strength in osteoporotic mice induced by ovariectomy. The secretion of extracellular vesicles plays a crucial role in the bone-protective effects induced by gut microbiota and the bacterium Akkermansia muciniphila.

ADVANCED SCIENCE (2021)

Add to Collection
Review Medicine, Research & Experimental

Extracellular Vesicles and Immune System in Ageing and Immune Diseases

So Yeong Cheon et al.

Summary: The immune system plays a crucial role in maintaining host homeostasis, but can worsen pathologies under conditions like ageing and inflammation. Extracellular vesicles are key mediators in cell-to-cell communication and disease propagation, making them a potential target for treatment and biomarker development in inflammatory diseases.

EXPERIMENTAL NEUROBIOLOGY (2021)

Add to Collection
Article Immunology

Proinflammatory Microenvironment During Kingella kingae Infection Modulates Osteoclastogenesis

Ayelen Ivana Pesce Viglietti et al.

Summary: Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children aged 6 to 48 months. Infection with K. kingae directly stimulates osteoclastogenesis and indirectly through a potent pro-inflammatory response that drives macrophages to become functional osteoclasts. Additionally, the osteoclastogenic capability of K. kingae is counteracted by their outer membrane vesicles in a concentration-dependent manner.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Bacterial Membrane Vesicles in Pneumonia: From Mediators of Virulence to Innovative Vaccine Candidates

Felix Behrens et al.

Summary: Respiratory infection-induced pneumonia is the leading cause of death in global infectious diseases, with antibiotics and vaccines helping to reduce the burden. However, lack or refusal of vaccines and antibiotics in some regions, the rise of multidrug-resistant pathogens, and high fatality rates even in patients treated appropriately pose a global threat. Bacteria's secretome contains extracellular vesicles that can trigger inflammatory responses and serve as promising vaccine candidates.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Cell Biology

Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo

Miriam Bittel et al.

Summary: Our study shows that bacterial OMVs can serve as a biological shuttle system for horizontal transfer of functional biomolecules between bacteria and mammalian host cells. Introducing E. coli engineered to express Cre-recombinase into mice demonstrated the transfer of bacterial OMVs to recipient cells in the gut and beyond. This evidence provides a method and proof of principle for inter-kingdom communication facilitated by OMVs.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Add to Collection
Article Cell Biology

Extracellular vesicles derived from the periodontal pathogen Filifactor alocis induce systemic bone loss through Toll-like receptor 2

Hyun Young Kim et al.

Summary: Periodontitis is an inflammatory disease caused by local infection in tooth-supporting tissue. While little is known about the causal effect of periodontitis on systemic bone resorption, this study found that extracellular vesicles from the periodontal pathogen Filifactor alocis induced bone loss and osteoclast differentiation via Toll-like receptor 2. Lipoproteins in the EVs were identified as responsible for the induced bone resorption.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Add to Collection
Article Cell Biology

Role of Outer Membrane Vesicles From Helicobacter pylori in Atherosclerosis

Na Wang et al.

Summary: Infection, particularly involving H. pylori, is believed to play a role in the development of atherosclerosis. Studies have shown that OMVs secreted by H. pylori accelerate atherosclerosis plaque formation by damaging endothelial cells. Components like CagA and LPS in H. pylori OMVs are implicated in this process, potentially through activation of the ROS/NF-kappa B signaling pathway.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection
Article Microbiology

Effects of pH on the Properties of Membrane Vesicles Including Glucosyltransferase in Streptococcus mutans

Yusuke Iwabuchi et al.

Summary: This study identified that the environmental pH plays a critical role in the biofilm formation of Streptococcus mutans, where the content and activity of membrane vesicles (MVs) under different conditions lead to variations in the formation of biofilms.

MICROORGANISMS (2021)

Add to Collection
Article Cell Biology

Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

Natalie J. Bitto et al.

Summary: Gram-positive bacteria produce membrane vesicles (MVs) containing microbe-associated molecular patterns (MAMPs) such as proteins, nucleic acids, and peptidoglycan, which can activate pattern recognition receptors (PRRs) in host epithelial cells and promote cytokine and chemokine release. Additionally, MVs can be degraded intracellularly through autophagy, enhancing our understanding of their immunostimulatory roles and fate within the host.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Lipoproteins Are Responsible for the Pro-Inflammatory Property of Staphylococcus aureus Extracellular Vesicles

Pradeep Kumar Kopparapu et al.

Summary: Staphylococcal aureus extracellular vesicles can induce inflammatory responses in host cells, with lipidated lipoproteins (Lpp) playing a crucial role in this activity while cell wall anchoring of surface proteins does not contribute to immune stimulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Oncology

Fecal Microbiota and Gut Microbe-Derived Extracellular Vesicles in Colorectal Cancer

Jihye Park et al.

Summary: The study found significant differences in the microbial composition, evenness, and diversity of fecal microbiota and gut microbe-derived EVs in colorectal cancer (CRC) subjects compared to control subjects. Additionally, there were noticeable changes in microbial composition, evenness, and diversity between late-stage and early-stage CRC subjects in both fecal microbiota and gut microbe-derived EVs. EVs derived from certain microbes could serve as novel biomarkers for diagnosing CRC and predicting CRC stages.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection
Article Microbiology

The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury

Shahrbanoo Keshavarz Azizi Raftar et al.

Summary: The study demonstrated that A. muciniphila and its EVs protect against HSC activation while improving liver fibrosis biomarkers, reducing liver histopathological damage, and modulating gut microbiota composition.

MICROBIOLOGY SPECTRUM (2021)

Add to Collection
Article Gastroenterology & Hepatology

Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway

Le Liu et al.

Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.

GUT MICROBES (2021)

Add to Collection
Article Biochemical Research Methods

Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides

Daniel Nyberg Larsen et al.

MOLECULAR & CELLULAR PROTEOMICS (2020)

Add to Collection
Article Multidisciplinary Sciences

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

Xiaogang Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection
Review Microbiology

The Contribution of Membrane Vesicles to Bacterial Pathogenicity in Cystic Fibrosis Infections and Healthcare Associated Pneumonia

Jolien Vitse et al.

FRONTIERS IN MICROBIOLOGY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver

Mariko Seyama et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Add to Collection
Article Microbiology

The extracellular vesicle of gut microbial Paenalcaligenes hominis is a risk factor for vagus nerve-mediated cognitive impairment

Kyung-Eon Lee et al.

MICROBIOME (2020)

Add to Collection
Article Microbiology

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Lydia Durant et al.

MICROBIOME (2020)

Add to Collection
Article Cell Biology

Transcriptomic microRNA Profiling of Dendritic Cells in Response to Gut Microbiota-Secreted Vesicles

Natalia Diaz-Garrido et al.

CELLS (2020)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Porphyromonas gingivalisOuter Membrane Vesicles Increase Vascular Permeability

C. Farrugia et al.

JOURNAL OF DENTAL RESEARCH (2020)

Add to Collection
Article Biotechnology & Applied Microbiology

Proteomic and metabolic characterization of membrane vesicles derived fromStreptococcus mutansat different pH values

Yina Cao et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Filifactor alocis-derived extracellular vesicles inhibit osteogenesis through TLR2 signaling

Min-Kyoung Song et al.

MOLECULAR ORAL MICROBIOLOGY (2020)

Add to Collection
Article Microbiology

Streptococcus mutansMembrane Vesicles Harboring Glucosyltransferases AugmentCandida albicansBiofilm Development

Ruixue Wu et al.

FRONTIERS IN MICROBIOLOGY (2020)

Add to Collection
Article Immunology

Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived FromBordetella pertussis

Maia L. Elizagaray et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Effect of the Extracellular Vesicle RNA Cargo From UropathogenicEscherichia colion Bladder Cells

Priscila Dauros-Singorenko et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Add to Collection
Article Immunology

Roles of membrane vesicles from Streptococcus mutans for the induction of antibodies to glucosyltransferase in mucosal immunity

Tomoyo Nakamura et al.

MICROBIAL PATHOGENESIS (2020)

Add to Collection
Article Multidisciplinary Sciences

Proteomic profile of extracellular vesicles released by Lactiplantibacillus plantarum BGAN8 and their internalization by non-polarized HT29 cell line

Svetlana Sokovic Bajic et al.

SCIENTIFIC REPORTS (2020)

Add to Collection
Article Multidisciplinary Sciences

Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice

Rezvan Yaghoubfar et al.

SCIENTIFIC REPORTS (2020)

Add to Collection
Article Immunology

Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling

Jungmin Yang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Delivery of Periodontopathogenic Extracellular Vesicles to Brain Monocytes and Microglial IL-6 Promotion by RNA Cargo

Jae Yeong Ha et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Add to Collection
Article Microbiology

Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans

Mark Lindholm et al.

JOURNAL OF ORAL MICROBIOLOGY (2020)

Add to Collection
Article Immunology

Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii

Chad R. Marion et al.

INFECTION AND IMMUNITY (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice

Eun-Chong Han et al.

FASEB JOURNAL (2019)

Add to Collection
Article Immunology

The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils

Megan M. Jones et al.

INFECTION AND IMMUNITY (2019)

Add to Collection
Article Microbiology

Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice

Fatemeh Ashrafian et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection
Review Oncology

Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy

Yingxuan Zhang et al.

CANCERS (2019)

Add to Collection
Article Microbiology

Pseudomonas aeruginosa Leucine Aminopeptidase Influences Early Biofilm Composition and Structure via Vesicle-Associated Antibiofilm Activity

Caitlin N. Esoda et al.

MBIO (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883

Hee Sang You et al.

INDIAN JOURNAL OF MICROBIOLOGY (2019)

Add to Collection
Article Biochemical Research Methods

Proteomic characterization of outer membrane vesicles from gut mucosa-derived fusobacterium nucleatum

Jinjing Liu et al.

JOURNAL OF PROTEOMICS (2019)

Add to Collection
Review Microbiology

Types and origins of bacterial membrane vesicles

Masanori Toyofuku et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Add to Collection
Article Multidisciplinary Sciences

Type-2 Diabetics Reduces Spatial Variation of Microbiome Based on Extracellur Vesicles from Gut Microbes across Human Body

Geumkyung Nah et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Article Microbiology

IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893

Shino Yamasaki-Yashiki et al.

BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH (2019)

Add to Collection
Article Medicine, Research & Experimental

Extracellular Vesicles Derived from Lactobacillus plantarum Increase BDNF Expression in Cultured Hippocampal Neurons and Produce Antidepressant-like Effects in Mice

Juli Choi et al.

EXPERIMENTAL NEUROBIOLOGY (2019)

Add to Collection
Article Immunology

Diet modulates colonic T cell responses by regulating the expression of a Bacteroides thetaiotaomicron antigen

Marta M. Wegorzewska et al.

SCIENCE IMMUNOLOGY (2019)

Add to Collection
Review Microbiology

Bacterial nanotubes: a conduit for intercellular molecular trade

Amit K. Baidya et al.

CURRENT OPINION IN MICROBIOLOGY (2018)

Add to Collection
Article Biochemistry & Molecular Biology

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation

Jose Carlos Santos et al.

EMBO JOURNAL (2018)

Add to Collection
Article Cell Biology

Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes

Natalie J. Bitto et al.

IMMUNOLOGY AND CELL BIOLOGY (2018)

Add to Collection
Article Microbiology

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses

Mario Codemo et al.

MBIO (2018)

Add to Collection
Article Multidisciplinary Sciences

Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV

Xin-Hong Dong et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Article Multidisciplinary Sciences

Dropping anchor: attachment of peptidylarginine deiminase via A-LPS to secreted outer membrane vesicles of Porphyromonas gingivalis

Giorgio Gabarrini et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Article Multidisciplinary Sciences

Modulation of gene transcription and epigenetics of colon carcinoma cells by bacterial membrane vesicles

Svitlana Vdovikova et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Letter Immunology

There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis

Giorgio Gabarrini et al.

VIRULENCE (2018)

Add to Collection
Article Microbiology

Outer Membrane Vesicles From Probiotic and Commensal Escherichia coli Activate NOD1-Mediated Immune Responses in Intestinal Epithelial Cells

Maria-Alexandra Canas et al.

FRONTIERS IN MICROBIOLOGY (2018)

Add to Collection
Article Microbiology

Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing

Magnus Paulsson et al.

FRONTIERS IN MICROBIOLOGY (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

Regis Stentz et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Add to Collection
Article Agriculture, Dairy & Animal Science

Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease

M. K. Seo et al.

JOURNAL OF DAIRY SCIENCE (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Candida albicans biofilm-induced vesicles confer drug resistance through matrix biogenesis

Robert Zarnowski et al.

PLOS BIOLOGY (2018)

Add to Collection
Article Gastroenterology & Hepatology

Outer membrane vesicles blebbing contributes to B. vulgatus mpk-mediated immune response silencing

Jan Kevin Maerz et al.

GUT MICROBES (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chaithanya Chelakkot et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Secretable Small RNAs via Outer Membrane Vesicles in Periodontal Pathogens

J. -W. Choi et al.

JOURNAL OF DENTAL RESEARCH (2017)

Add to Collection
Article Multidisciplinary Sciences

Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis

Masanori Toyofuku et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Multidisciplinary Sciences

Bacterial outer membrane vesicles suppress tumor by interferon-γ- mediated antitumor response

Oh Youn Kim et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Microbiology

Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells

Eloise J. O'Donoghue et al.

PLOS PATHOGENS (2017)

Add to Collection
Article Microbiology

Intestinal Anti-inflammatory Effects of Outer Membrane Vesicles from Escherichia coli Nissle 1917 in DSS-Experimental Colitis in Mice

Maria-Jose Fabrega et al.

FRONTIERS IN MICROBIOLOGY (2017)

Add to Collection
Article Immunology

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Jessica D. Cecil et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection
Article Multidisciplinary Sciences

Outer membrane vesicles secreted by pathogenic and nonpathogenic Bacteroides fragilis represent different metabolic activities

Natalya B. Zakharzhevskaya et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Multidisciplinary Sciences

Escherichia coli outer membrane vesicles can contribute to sepsis induced cardiac dysfunction

Kristina Svennerholm et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Microbiology

Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection

Charlotte Volgers et al.

BMC MICROBIOLOGY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells

Hyun-Il Choi et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Acquisition of Phage Sensitivity by Bacteria through Exchange of Phage Receptors

Elhanan Tzipilevich et al.

CELL (2017)

Add to Collection
Article Cell Biology

Campylobacter jejuni outer membrane vesicle-associated proteolytic activity promotes bacterial invasion by mediating cleavage of intestinal epithelial cell E-cadherin and occludin

Abdi Elmi et al.

CELLULAR MICROBIOLOGY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

Sivapriya Kailasan Vanaja et al.

CELL (2016)

Add to Collection
Review Cell Biology

Mechanisms of outer membrane vesicle entry into host cells

Eloise J. O'Donoghue et al.

CELLULAR MICROBIOLOGY (2016)

Add to Collection
Article Immunology

Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4-and mTOR-Dependent Manner

Tobias Waller et al.

INFECTION AND IMMUNITY (2016)

Add to Collection
Article Clinical Neurology

Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

Emiko Aizawa et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

Add to Collection
Article Allergy

Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

Jung-Hwan Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Add to Collection
Article Multidisciplinary Sciences

Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis

Wanatchaporn Arunmanee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection
Article Multidisciplinary Sciences

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Hiutung Chu et al.

SCIENCE (2016)

Add to Collection
Article Microbiology

Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages

Anna Lena Jung et al.

PLOS PATHOGENS (2016)

Add to Collection
Article Microbiology

Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial Cells

Allon Weiner et al.

PLOS PATHOGENS (2016)

Add to Collection
Article Microbiology

Outer Membrane Vesicles and Soluble Factors Released by Probiotic Escherichia coil Nissle 1917 and Commensal ECOR63 Enhance Barrier Function by Regulating Expression of Tight Junction Proteins in Intestinal Epithelial Cells

Carina-Shianya Alvarez et al.

FRONTIERS IN MICROBIOLOGY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Porphyromonas gingivalis-derived outer membrane vesicles promote calcification of vascular smooth muscle cells through ERK1/2-RUNX2

Wen Wei Yang et al.

FEBS OPEN BIO (2016)

Add to Collection
Article Multidisciplinary Sciences

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Jessica D. Cecil et al.

PLOS ONE (2016)

Add to Collection
Review Biochemistry & Molecular Biology

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Hina Kalra et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Rho kinase mediates Porphyromonas gingivalis outer membrane vesicle-induced suppression of endothelial nitric oxide synthase through ERK1/2 and p38 MAPK

Yue Jia et al.

ARCHIVES OF ORAL BIOLOGY (2015)

Add to Collection
Article Immunology

Altered fecal microbiota composition in patients with major depressive disorder

Haiyin Jiang et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

Khalid Al-Nedawi et al.

FASEB JOURNAL (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Porphyromonas gingivalis Gingipains RgpA, RgpB, and Kgp

Masaaki Nakayama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Add to Collection
Article Biochemical Research Methods

Proteome Profiles of Outer Membrane Vesicles and Extracellular Matrix of Pseudomonas aeruginosa Biofilms

Narciso Couto et al.

JOURNAL OF PROTEOME RESEARCH (2015)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Outer membrane vesicles of Tannerella forsythia: biogenesis, composition, and virulence

V. Friedrich et al.

MOLECULAR ORAL MICROBIOLOGY (2015)

Add to Collection
Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

Add to Collection
Review Microbiology

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

Carmen Schwechheimer et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Add to Collection
Review Microbiology

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

Lisa Brown et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Add to Collection
Article Multidisciplinary Sciences

Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle

Youngwoo Choi et al.

SCIENTIFIC REPORTS (2015)

Add to Collection
Article Cell Biology

Fusion of Legionella pneumophila outer membrane vesicles with eukaryotic membrane systems is a mechanism to deliver pathogen factors to host cell membranes

Jens Jaeger et al.

CELLULAR MICROBIOLOGY (2015)

Add to Collection
Article Microbiology

Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell-cell contacts and induce histone H1 binding to ATP in epithelial cells

Maria V. Turkina et al.

FEMS MICROBIOLOGY LETTERS (2015)

Add to Collection
Review Immunology

Immune modulation by bacterial outer membrane vesicles

Maria Kaparakis-Liaskos et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Add to Collection
Article Immunology

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

Bernard Thay et al.

INFECTION AND IMMUNITY (2014)

Add to Collection
Article Oncology

Escherichia coli-derived outer membrane vesicles are genotoxic to human enterocyte-like cells

Peter C. Tyrer et al.

INFECTIOUS AGENTS AND CANCER (2014)

Add to Collection
Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

Laura Ann Mulcahy et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Add to Collection
Article Biochemistry & Molecular Biology

Pulmonary Inflammation Induced by Bacteria-Free Outer Membrane Vesicles from Pseudomonas aeruginosa

Kyong-Su Park et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Add to Collection
Article Microbiology

Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity

Yizu Jiao et al.

CELL HOST & MICROBE (2013)

Add to Collection
Article Multidisciplinary Sciences

Staphylococcus aureus α-Toxin-Dependent Induction of Host Cell Death by Membrane-Derived Vesicles

Bernard Thay et al.

PLOS ONE (2013)

Add to Collection
Article Multidisciplinary Sciences

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

Chil-sung Kang et al.

PLOS ONE (2013)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Porphyromonas gingivalis Outer Membrane Vesicles Mediate Coaggregation and Piggybacking of Treponema denticola and Lachnoanaerobaculum saburreum

Daniel Grenier

INTERNATIONAL JOURNAL OF DENTISTRY (2013)

Add to Collection
Article Allergy

Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses

M. -R. Kim et al.

ALLERGY (2012)

Add to Collection
Article Microbiology

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

Yue Shen et al.

CELL HOST & MICROBE (2012)

Add to Collection
Article Microbiology

Klebsiella pneumoniae secretes outer membrane vesicles that induce the innate immune response

Je Chul Lee et al.

FEMS MICROBIOLOGY LETTERS (2012)

Add to Collection
Article Immunology

Perinuclear Localization of Internalized Outer Membrane Vesicles Carrying Active Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans

Pramod Kumar Rompikuntal et al.

INFECTION AND IMMUNITY (2012)

Add to Collection
Article Immunology

Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy

Patricia Lopez et al.

VACCINE (2012)

Add to Collection
Article Immunology

Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells

R. Maldonado et al.

MICROBIAL PATHOGENESIS (2011)

Add to Collection
Article Microbiology

A Pseudomonas aeruginosa Toxin that Hijacks the Host Ubiquitin Proteolytic System

Jennifer M. Bomberger et al.

PLOS PATHOGENS (2011)

Add to Collection
Article Cell Biology

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

Maria Kaparakis et al.

CELLULAR MICROBIOLOGY (2010)

Add to Collection
Article Immunology

Hemagglutinin/Adhesin domains of Porphyromonas gingivalis play key roles in coaggregation with Treponema denticola

Rieko Ito et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2010)

Add to Collection
Review Gastroenterology & Hepatology

Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease

Kouichi Miura et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2010)

Add to Collection
Article Immunology

Entry of Porphyromonas gingivalis Outer Membrane Vesicles into Epithelial Cells Causes Cellular Functional Impairment

Nobumichi Furuta et al.

INFECTION AND IMMUNITY (2009)

Add to Collection
Article Immunology

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

Nobumichi Furuta et al.

INFECTION AND IMMUNITY (2009)

Add to Collection
Article Biochemical Research Methods

Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles

Eun-Young Lee et al.

PROTEOMICS (2009)

Add to Collection
Article Microbiology

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles

Jennifer M. Bomberger et al.

PLOS PATHOGENS (2009)

Add to Collection
Article Immunology

Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles

Frank Galka et al.

INFECTION AND IMMUNITY (2008)

Add to Collection
Article Immunology

Porphyromonas gingivalis vesicles enhance attachment, and the leucine-rich repeat BspA protein is required for invasion of epithelial cells by Tannerella forsythia

Satoru Inagaki et al.

INFECTION AND IMMUNITY (2006)

Add to Collection
Article Dentistry, Oral Surgery & Medicine

Interaction of Porphyromonas gingivalis with low-density lipoproteins:: implications for a role for periodontitis in atherosclerosis

H Miyakawa et al.

JOURNAL OF PERIODONTAL RESEARCH (2004)

Add to Collection
Article Microbiology

Effect of Porphyromonas gingivalis vesicles on coaggregation of staphylococcus aureus to oral microorganisms

A Kamaguchi et al.

CURRENT MICROBIOLOGY (2003)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.