Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2023.1193184
Keywords
lichuan virus (LICV); Orthobunyavirus; Tete virus; Culicoides biting midges; evolution
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In July 2018, a new virus belonging to the Tete serogroup, named Lichuan virus, was isolated from Culicoides biting midges in Lichuan County, Jiangxi Province, China. This virus showed significant cytopathic effects and resulted in disease and death in suckling mice.
In July 2018, a virus (JXLC1806-2) was isolated from Culicoides biting midges collected in Lichuan County, Jiangxi Province, China. The virus isolate showed significant cytopathic effects within 48 hours after inoculation with mammalian cells (BHK-21). JXLC1806-2 virus could form plaques in BHK-21 cells, and the virus titer was 1x10(5.6) pfu/mL. After inoculation with the virus, suckling mice developed disease and died. The nucleotide and amino sequence analysis showed that the JXLC1806-2 virus genome was composed of S, M and L segments. Phylogenetic analysis showed that the S, M and L genes of JXLC1806-2 virus belonged to the Tete serogroup, Orthobunyavirus, but formed an independent evolutionary branch from the other members of the Tete serogroup. The results showed that the JXLC1806-2 virus, which was named as Lichuan virus, is a new member of Tete serogroup, and this is the first time that a Tete serogroup virus has been isolated in China.
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