☆ 4.8 Review

Normal and dysregulated crosstalk between iron metabolism and erythropoiesis

ELIFE (2023)

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Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

Carla Casu et al.

HAEMATOLOGICA (2016)

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Letter Hematology

Combination of Tmprss6-ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

Carla Casu et al.

HAEMATOLOGICA (2016)

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Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia

Gautam Rishi et al.

AMERICAN JOURNAL OF HEMATOLOGY (2016)

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Article Biochemistry & Molecular Biology

Erythroid cell mitochondria receive endosomal iron by a kiss-and-run mechanism

Arnel Hamdi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

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A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages

Christopher R. Edwards et al.

BLOOD (2016)

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Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera

Carla Casu et al.

BLOOD (2016)

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Clinical iron deficiency disturbs normal human responses to hypoxia

Matthew C. Frise et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Oncology

Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes

H. Dolatshad et al.

LEUKEMIA (2016)

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Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Stanley Chun-Wei Lee et al.

NATURE MEDICINE (2016)

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Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

Rebekka K. Schneider et al.

NATURE MEDICINE (2016)

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Iron-Refractory Iron Deficiency Anemia May Not Lead to Neurocognitive Dysfunction: A Case Report

Valerie Arsenault et al.

PEDIATRICS (2016)

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Article Hematology

Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia

Paul J. Schmidt et al.

AMERICAN JOURNAL OF HEMATOLOGY (2015)

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Article Physiology

Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly

Elena Gammella et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2015)

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Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia

Leon Kautz et al.

BLOOD (2015)

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SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

Supak Jenkitkasemwong et al.

CELL METABOLISM (2015)

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Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

Reiya Taniguchi et al.

NATURE COMMUNICATIONS (2015)

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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Joseph D. Mancias et al.

ELIFE (2015)

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The second transferrin receptor regulates red blood cell production in mice

Antonella Nai et al.

BLOOD (2015)

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Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron

V. Visconte et al.

LEUKEMIA (2015)

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Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

H. Dolatshad et al.

LEUKEMIA (2015)

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Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Sara Gardenghi et al.

BLOOD (2014)

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Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver

Zhenhua Sui et al.

BLOOD (2014)

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MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

Satoshi Toda et al.

BLOOD (2014)

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Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

Raajit Rampal et al.

BLOOD (2014)

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Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E

Jie Li et al.

BLOOD (2014)

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Global transcriptome analyses of human and murine terminal erythroid differentiation

Xiuli An et al.

BLOOD (2014)

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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

Thomas Sonnweber et al.

GUT (2014)

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Anemia of Inflammation

Elizabeta Nemeth et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2014)

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Iron-Refractory Iron Deficiency Anemia (IRIDA)

Matthew M. Heeney et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2014)

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HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

Jean-Benoit Arlet et al.

NATURE (2014)

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle et al.

NATURE CELL BIOLOGY (2014)

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Identification of erythroferrone as an erythroid regulator of iron metabolism

Leon Kautz et al.

NATURE GENETICS (2014)

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Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo

Jingping Hu et al.

BLOOD (2013)

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Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis

Jing Liu et al.

BLOOD (2013)

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Erythroid development in the mammalian embryo

Margaret H. Baron et al.

BLOOD CELLS MOLECULES AND DISEASES (2013)

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The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice

Guillem Casanovas et al.

HAEMATOLOGICA (2013)

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The Evaluation of iron overload through hepcidin level and its related factors in myelodysplastic syndromes

Shucheng Gu et al.

HEMATOLOGY (2013)

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Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

Sebastien Leidgens et al.

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Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

Chante L. Richardson et al.

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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

Shuling Guo et al.

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Iron overload impairs proliferation of erythroid progenitors cells (BFU-E) from patients with myelodysplastic syndromes

Julia Hartmann et al.

LEUKEMIA RESEARCH (2013)

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Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

Pedro Ramos et al.

NATURE MEDICINE (2013)

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CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

Andrew Chow et al.

NATURE MEDICINE (2013)

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Cardiovascular Events and Intensity of Treatment in Polycythemia Vera

Roberto Marchioli et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Caroline A. Enns et al.

PLOS ONE (2013)

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Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

Erik R. Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis

Sadanori Watanabe et al.

CELL REPORTS (2013)

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Erythropoiesis: Development and Differentiation

Elaine Dzierzak et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2013)

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Enucleation of human erythroblasts involves non-muscle myosin IIB

Kumi Ubukawa et al.

BLOOD (2012)

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Signaling and cytoskeletal requirements in erythroblast enucleation

Diamantis G. Konstantinidis et al.

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Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

Pauline Lee et al.

BLOOD CELLS MOLECULES AND DISEASES (2012)

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Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

Bo Qiao et al.

CELL METABOLISM (2012)

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The effect of iron overload and chelation on erythroid differentiation

Kazuki Taoka et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2012)

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Mammalian erythroblast enucleation requires PI3K-dependent cell polarization

Junxia Wang et al.

JOURNAL OF CELL SCIENCE (2012)

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Selective toxicity towards myelodysplastic hematopoietic progenitors - Another rationale for iron chelation in MDS

E. Fibach et al.

LEUKEMIA RESEARCH (2012)

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HIF1α synergizes with glucocorticoids to promote BFU-E progenitor self-renewal

Johan Flygare et al.

BLOOD (2011)

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β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Yelena Ginzburg et al.

BLOOD (2011)

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The multifunctional role of EKLF/KLF1 during erythropoiesis

Miroslawa Siatecka et al.

BLOOD (2011)

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Membrane assembly during erythropoiesis

Jing Liu et al.

CURRENT OPINION IN HEMATOLOGY (2011)

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Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

Luca Malcovati et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)

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Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

Gloria C. Preza et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis

Susanna Porcu et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

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Hepcidin Levels and Their Determinants in Different Types of Myelodysplastic Syndromes

Valeria Santini et al.

PLOS ONE (2011)

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Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling

Anne-Laure Talbot et al.

PLOS ONE (2011)

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Membrane remodeling during reticulocyte maturation

Jing Liu et al.

BLOOD (2010)

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Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

Hana Forejtnikova et al.

BLOOD (2010)

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Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

Barbra J. Sasu et al.

BLOOD (2010)

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Iron control of erythroid development by a novel aconitase-associated regulatory pathway

Grant C. Bullock et al.

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Vesicle trafficking plays a novel role in erythroblast enucleation

Ganesan Keerthivasan et al.

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Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease

Hajime Akada et al.

BLOOD (2010)

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Cause of Death in Patients With Lower-Risk Myelodysplastic Syndrome

Farshid Dayyani et al.

CANCER (2010)

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Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

Peng Ji et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)

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Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position-7007 of the FPN1 promoter

Samuele Marro et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)

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Transferrin therapy ameliorates disease in β-thalassemic mice

Huihui Li et al.

NATURE MEDICINE (2010)

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Iron chelation therapy associated with improvement of hematopoiesis in transfusion-dependent patients

Esther Natalie Oliva et al.

TRANSFUSION (2010)

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Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation

Ji Zhang et al.

BLOOD (2009)

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Intestinal Hypoxia-inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

Yatrik M. Shah et al.

CELL METABOLISM (2009)

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A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

De-Liang Zhang et al.

CELL METABOLISM (2009)

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Exogenous iron increases hemoglobin in β-thalassemic mice

Yelena Z. Ginzburg et al.

EXPERIMENTAL HEMATOLOGY (2009)

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Decreased serum prohepcidin concentration in patients with polycythemia vera

Justyna Kwapisz et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2009)

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Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

John C. Chambers et al.

NATURE GENETICS (2009)

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Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Santhi K. Ganesh et al.

NATURE GENETICS (2009)

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Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

Beben Benyamin et al.

NATURE GENETICS (2009)

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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Nicole Soranzo et al.

NATURE GENETICS (2009)

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Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

Ke Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Rheumatology

Role of Interleukin-6 in the Anemia of Chronic Disease

Dominic S. C. Raj

SEMINARS IN ARTHRITIS AND RHEUMATISM (2009)

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The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the early prepolycythemic phase of polycythemia vera and essential thrombocythemia

Umberto Gianelli et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2008)

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Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia

Ilaria V. Libani et al.

BLOOD (2008)

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Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

Mondira Kundu et al.

BLOOD (2008)

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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

Paul J. Schmidt et al.

CELL METABOLISM (2008)

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The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Laura Silvestri et al.

CELL METABOLISM (2008)

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Ontogeny of erythropoiesis

James Palis

CURRENT OPINION IN HEMATOLOGY (2008)

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Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform

P. Valent et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2008)

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The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

Andrew J. Ramsay et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

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A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

Maria Antonietta Melis et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2008)

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Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2

Peng Ji et al.

NATURE CELL BIOLOGY (2008)

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

Karin E. Finberg et al.

NATURE GENETICS (2008)

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A prognostic score for patients with lower risk myelodysplastic syndrome

G. Garcia-Manero et al.

LEUKEMIA (2008)

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Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F

Xiaohui Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications

Yang-Sung Sohn et al.

BLOOD (2008)

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Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietin

Melissa M. Rhodes et al.

BLOOD (2008)

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Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts

Zachary P. Nearman et al.

AMERICAN JOURNAL OF HEMATOLOGY (2007)

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Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study

Christine E. McLaren et al.

AMERICAN JOURNAL OF HEMATOLOGY (2007)

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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Toshihiko Tanno et al.

NATURE MEDICINE (2007)

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Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera

A. Pardanani et al.

LEUKEMIA (2007)

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The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload

Clara Camaschella et al.

BLOOD (2007)

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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

Jodie L. Babitt et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Sara Gardenghi et al.

BLOOD (2007)

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BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

John M. Perry et al.

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JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

Linda M. Scott et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Suppression of hepcidin during anemia requires erythropoietic activity

Mihwa Pak et al.

BLOOD (2006)

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Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion

Shivani Soni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

Jaroslav Truksa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

M. Vokurka et al.

PHYSIOLOGICAL RESEARCH (2006)

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Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision making

L Malcovati et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

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Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

H Yoshida et al.

NATURE (2005)

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Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages

T Ganz

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2005)

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LPI-labile plasma iron in iron overload

ZI Cabantchik et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2005)

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

C James et al.

NATURE (2005)

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

R Kralovics et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

RL Levine et al.

CANCER CELL (2005)

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

EJ Baxter et al.

LANCET (2005)

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Medical progress: Anemia of chronic disease

G Weiss et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

A Donovan et al.

CELL METABOLISM (2005)

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Transferrin: structure, function and potential therapeutic actions

PT Gomme et al.

DRUG DISCOVERY TODAY (2005)

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Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to αv integrins

TJ Mankelow et al.

BLOOD (2004)

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

E Nemeth et al.

SCIENCE (2004)

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Regulation of transferrin receptor 2 protein levels by transferrin

A Robb et al.

BLOOD (2004)

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Diferric transferrin regulates transferrin receptor 2 protein stability

MB Johnson et al.

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HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface

AM Giannetti et al.

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Labile plasma iron in iron overload: redox activity and susceptibility to chelation

BP Esposito et al.

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Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

JD Hooper et al.

BIOCHEMICAL JOURNAL (2003)

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Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system

J Zhang et al.

BLOOD (2003)

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Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling

A Kolbus et al.

BLOOD (2003)

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Hepcidin, a new iron regulatory peptide

G Nicolas et al.

BLOOD CELLS MOLECULES AND DISEASES (2002)

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Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

K Kawane et al.

SCIENCE (2001)

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

CH Park et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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An iron-regulated ferric reductase associated with the absorption of dietary iron

AT McKie et al.

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Polycythemia rubra vera versus secondary polycythemias. A clinicopathological evaluation of distinctive features in 199 patients

J Thiele et al.

PATHOLOGY RESEARCH AND PRACTICE (2001)

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Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

MJ Bennett et al.

NATURE (2000)

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