A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis

Article Biochemistry & Molecular Biology

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation

Chun-xiao Wang et al.

Summary: Auriculasin promotes CRC cell apoptosis, ferroptosis, and oxeiptosis by inducing ROS generation, inhibiting cell viability, invasion, and clone formation, showing significant antitumor effects.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Review Pharmacology & Pharmacy

Modulating undruggable targets to overcome cancer therapy resistance

Catherine Passirani et al.

Summary: Identifying and validating proteins involved in resistance mechanisms is crucial for innovative therapeutic strategies to improve the clinical outcome of cancer patients. Rational treatment strategies targeting transcription factors, pseudokinases, nuclear export receptors, and immunogenic cell death show promise in overcoming therapy resistance. The success in inhibiting specific proteins and pathways implicated in drug resistance illustrates the potential of targeted therapies and immunotherapies to improve clinical outcomes.

DRUG RESISTANCE UPDATES (2022)

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Article Biochemistry & Molecular Biology

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

Wen Zhang et al.

Summary: In this study, we reported for the first time that Bufotalin (BT), a natural small molecule, is a glutathione peroxidase 4 (GPX4) inhibitor that can trigger ferroptosis in non-small cell lung cancer cells. BT induces ferroptosis and lipid peroxidation by accelerating GPX4 degradation and increasing intracellular Fe2+.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Pharmacology & Pharmacy

Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism

Zhao Cui et al.

Summary: Although sorafenib has limitations in clinical liver cancer therapy due to side effects and drug resistance, the combined application of DHA and Sora showed synergistic inhibitory effects on HepG2 and SW480 cells. The combination also enhanced the efficacy of Sora on xenograft tumors in nude mice by inducing ferroptosis and inhibiting energy metabolism in HepG2 cells.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

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Review Cell Biology

The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer

Yingying Hu et al.

Summary: Artemisinin and its derivatives have shown antitumor effects in addition to their antimalarial properties. The mechanisms of antitumor activity involve cell cycle regulation, inhibition of tumor angiogenesis, DNA damage, and induction of ferroptosis. This review focuses on the potential of artemisinin derivatives in regulating ferroptosis and provides a basis for their use as anticancer drugs in clinical practice.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Oncology

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway

Liyi Zhang et al.

Summary: This study found that Ophiopogonin B (OP-B) suppresses gastric cancer cell viability and induces ferroptosis by blocking the GPX4/xCT system.

ONCOLOGY LETTERS (2022)

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Article Oncology

Network Pharmacology Study and Experimental Validation of Yiqi Huayu Decoction Inducing Ferroptosis in Gastric Cancer

Siyuan Song et al.

Summary: This study identified the mechanism by which Yiqi Huayu Decoction (YQHY) induces ferroptosis in gastric cancer (GC) using network pharmacology and experimental validation. The results showed that YQHY can induce ferroptosis in GC by affecting the JAK2-STAT3 pathway and the expression of ACSL4. This induction of ferroptosis may be one of the possible mechanisms of YQHY's anti-recurrence and metastasis of GC.

FRONTIERS IN ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity

Lu Yao et al.

Summary: CQDs derived from chlorogenic acid (ChA) from coffee show promising potential as biocompatible nanozymes for anticancer therapeutics. In vivo experiments demonstrate that ChA CQDs not only significantly inhibit tumor growth but also activate systemic antitumor immune responses by recruiting immune cells.

ACS NANO (2022)

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Article Biochemistry & Molecular Biology

A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells

Xing Du et al.

Summary: Lycium barbarum polysaccharide (LBP) effectively prevents breast cancer cell proliferation and promotes ferroptosis via the xCT/GPX4 pathway, making it a potential therapeutic option for breast cancer.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2022)

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Article Pharmacology & Pharmacy

GPX4 Plays a Crucial Role in Fuzheng Kang'ai Decoction-Induced Non-Small Cell Lung Cancer Cell Ferroptosis

Yue-Yang Zhao et al.

Summary: In this study, it was found that FZKA induces ferroptosis in NSCLC cells by increasing lipid peroxidation and cellular Fe2+ Ion levels, while inhibiting GPX4 and system xc(-). Overexpressing GPX4 reversed the ferroptosis-inducing effect of FZKA, and these findings were validated in vivo using an animal model. These results reveal a novel molecular mechanism by which FZKA treats NSCLC by targeting GPX4.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Genetics & Heredity

Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3β-Mediated Keap1/Nrf2/HO-1 Signalling Pathway

Senling Feng et al.

Summary: Nobiletin, a natural product, induces ferroptosis in melanoma cells by regulating the GSK3β-mediated Keap1/Nrf2/HO-1 signaling pathway, demonstrating its potential as an anti-tumor agent.

FRONTIERS IN GENETICS (2022)

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Article Oncology

PITPNA-AS1/miR-98-5p to Mediate the Cisplatin Resistance of Gastric Cancer

Zhongling Ma et al.

Summary: This study found that the overexpression of lncRNA PITPNA-AS1 in gastric cancer is associated with poor survival. Inhibiting PITPNA-AS1 can inhibit cell growth and induce apoptotic cell death in gastric cancer cells. Furthermore, PITPNA-AS1 is elevated in cisplatin-resistant gastric cancer cells, and its inhibition can increase the sensitivity of gastric cancer cells to cisplatin treatment.

JOURNAL OF ONCOLOGY (2022)

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Article Oncology

Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells

Yue Li et al.

Summary: This study demonstrated that Scutellaria barbata suppresses the growth of hepatocellular carcinoma cells by inducing ferroptosis, potentially by promoting iron perioxidation and lipid ROS metabolism. Additionally, S. barbata can inhibit HCC tumorigenicity in vivo by inducing ferroptosis of HCC cells.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Ferroptosis-Mediated Formation of Tumor-Promoting Immune Microenvironment

Qing Bi et al.

Summary: This review introduces the mechanisms of ferroptosis, discusses the crosstalk between ferroptosis and cancer, demonstrates the potential ways in which ferroptosis shapes the pro-tumor immune microenvironment, and presents thoughts on ferroptosis-based cancer therapies.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

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Article Biotechnology & Applied Microbiology

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

Zuli Wang et al.

Summary: Ferroptosis is primarily caused by intracellular iron activity and lipid peroxidation, while LINC00618 promotes apoptosis and ferroptosis by regulating the levels of BAX, caspase-3, ROS, and iron. LSH and SLC7A11 also play crucial roles in this process.

MOLECULAR THERAPY (2021)

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Article Plant Sciences

Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

Jian-Shu Lou et al.

Summary: The study found that ginkgetin derived from Ginkgo biloba leaves enhances DDP-induced cytotoxicity in NSCLC cells through inducing ferroptosis. The results indicate that, in addition to enhancing DDP-induced cytotoxicity, ginkgetin can disrupt redox homeostasis in DDP-treated cells and enhance apoptosis.

PHYTOMEDICINE (2021)

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Article Cell Biology

Tumor heterogeneity in autophagy-dependent ferroptosis

Jingbo Li et al.

Summary: Autophagy plays a complex role in cellular stress and can either promote survival or trigger death. Recent evidence suggests that the molecular machinery of autophagy facilitates ferroptosis, a regulated cell death process. The study found tumor heterogeneity in autophagy-dependent ferroptosis, showing different biological behaviors in terms of cell death dynamics.

AUTOPHAGY (2021)

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Article Pharmacology & Pharmacy

Quercetin induces p53-independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species-dependent ferroptosis

Zi-Xuan Wang et al.

Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Chrysin induces autophagy-dependent ferroptosis to increase chemosensitivity to gemcitabine by targeting CBR1 in pancreatic cancer cells

Ling Zhou et al.

Summary: Recent studies have shown that CBR1 is highly expressed in pancreatic cancer tissues and plays a role in regulating ROS generation and gemcitabine sensitivity. Inhibition of CBR1 by chrysin increases cellular ROS levels, leading to ferroptotic death in PC cells and enhancing sensitivity to gemcitabine. These findings suggest CBR1 as a potential therapeutic target for PC treatment and elucidate a novel mechanism underlying the anti-tumor effects of chrysin.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Biochemistry & Molecular Biology

Cellular degradation systems in ferroptosis

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent oxidative cell death driven by lipid peroxidation. Various antioxidant systems play a significant role in preventing ferroptotic death. The cellular degradation systems play a dual role in regulating the ferroptotic response.

CELL DEATH AND DIFFERENTIATION (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway

Jiang Xiaofei et al.

Summary: OA activates ferroptosis in Hela cells by promoting ACSL4 expression, reducing cell survival rate, which may be a potential approach for the treatment of cervical cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cell Biology

The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy

Zhen Tang et al.

Summary: Ursolic acid, an active ingredient isolated from Radix Actinidiae chinensis, has strong antitumour effects on osteosarcoma cells and synergistic cytotoxic effect with cisplatin. Mechanistic studies show that ursolic acid induces ferroptosis by activating autophagy and enhances the DNA-damaging effect of cisplatin on osteosarcoma cells, suggesting it as a nontoxic adjuvant to enhance chemotherapy effectiveness.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential

Shuai Huang et al.

Summary: CuB has cytotoxicity towards nasopharyngeal carcinoma cells and may induce ferroptosis as a potential mechanism.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway

Yang Xie et al.

Summary: Breast cancer is a major malignant tumor in females, and plant-derived biflavonoids have shown potential as novel anticancer agents. A study isolated six C-3'-C-6' biflavonoids from Selaginella trichoclada for the first time, with one compound, RF-A, demonstrating the strongest anticancer activity. RF-A induced non-apoptotic cell death in MCF-7 breast cancer cells through the ferroptosis pathway, suggesting its potential as a treatment for breast cancer.

BIOORGANIC CHEMISTRY (2021)

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Review Biochemical Research Methods

Non-coding RNA in cancer

Huiwen Yan et al.

Summary: The majority of the human genome is transcribed into non-coding RNAs (ncRNAs) that play crucial roles in regulating cancer initiation and progression. This review focuses on recent studies of the function, regulatory mechanisms, and therapeutic potential of ncRNAs such as microRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), and PIWI interacting RNA (piRNA) in various types of cancers.

NON-CODING GENOME (2021)

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Review Oncology

Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities

Peyman Tabnak et al.

Summary: Lung cancer is one of the most common and deadliest cancers worldwide. Research shows that ferroptosis can contribute to cell death in tumor cells, making it a promising strategy for lung cancer treatment. Understanding the molecular mechanisms of ferroptosis is crucial for future studies and potential therapeutic interventions.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway

Yiwei Chen et al.

Summary: Colon cancer is the third most common cancer globally, with high mortality rates even with current treatments. Traditional Chinese medicine, particularly Camellia nitidissima Chi (CNC), has shown inhibitory effects on colon cancer proliferation and apoptosis induction. Proteomic analysis revealed alterations in proteins involved in biological processes related to tumor occurrence and development, particularly in the ferroptosis pathway. This suggests that CNC may regulate colon cancer progression through ferroptosis and could be a promising treatment option.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

The Role of Iron in Cancer Progression

Qianqian Guo et al.

Summary: Iron is closely related to the occurrence and development of tumors, playing a crucial role in cell death. Research on iron metabolism disorders and the use of iron in tumor treatment is important for the prevention and treatment of tumors.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

A narrative review of mechanisms of ferroptosis in cancer: new challenges and opportunities

Mingyan Jiang et al.

Summary: This article reviews the specific mechanism of ferroptosis in cancer and discusses the opportunities and challenges of ferroptosis-based cancer therapy, which has the potential to inhibit tumorigenesis and reduce adverse effects of current treatments.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Oncology

Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells

Yongfei He et al.

Summary: Atractylodin inhibits the proliferation, migration, and invasion of liver cancer cells, regulates the cell cycle, induces cell apoptosis, and G1 phase cell cycle arrest. Additionally, atractylodin may induce ferroptosis in HCC cells.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Oncology

CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma

Zhixian Wang et al.

Summary: In this study, it was found that CREB is highly expressed in LUAD and can promote cell death by inhibiting lipid peroxidation, with close association with GPX4 and EP300. Targeting the CREB/EP300/GPX4 axis may provide new strategies for treating LUAD, especially in tumors with higher malignancy.

ONCOLOGY REPORTS (2021)

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Article Plant Sciences

Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells

Jingjing Du et al.

Summary: Shuganning injection (SGNI), a traditional Chinese patent medicine, selectively inhibits the proliferation of TNBC cells through induction of ferroptosis dependent on heme oxygenase 1 (HO-1). HO-1 promotes intracellular labile iron pool accumulation, leading to ferroptotic cell death of TNBC cells.

PHYTOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

Ying Liu et al.

Summary: The new JDA derivative a2 was found to inhibit the growth of gastric cancer cells and induce ferroptosis. Through the autophagy pathway, a2 caused ferrous iron accumulation, and prevention of this process alleviated a2-induced elevation of ferrous iron and cell growth inhibition, demonstrating stronger anti-cancer activity in gastric cancer xenograft models compared to 5-fluorouracil.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Pharmacology & Pharmacy

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1

Na Kong et al.

Summary: Baicalin, an active component in Scutellaria baicalensis Georgi, shows anticancer activity in bladder cancer cells by inducing ferroptosis, suggesting a potential novel therapeutic approach for bladder cancer treatment.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Oncology

Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy

Lanyu Li et al.

Summary: Ovarian cancer, as one of the deadliest malignancies, requires more effective treatment options beyond traditional methods. The potential connection between ferroptosis and ovarian cancer has raised interest in exploring new therapeutic approaches. Further research is needed to understand the role of ferroptosis in ovarian cancer treatment and to identify potential pathways for intervention.

FRONTIERS IN ONCOLOGY (2021)

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Review Pharmacology & Pharmacy

Recent progress on targeting ferroptosis for cancer therapy

Guangxiang Xu et al.

Summary: Ferroptosis is a novel mode of cell death that has become a target for antitumor therapy. Research has identified various mechanisms regulating the sensitivity of cancer cells to ferroptosis, and progress has been made in exploring ferroptosis-related drugs.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Dihydroisotanshinone I induced ferroptosis and apoptosis of lung cancer cells

Ching-Yuan Wu et al.

Summary: In this study, it was found that dihydroisotanshinone I extracted from danshen can inhibit the growth of lung cancer cells through inducing apoptosis and ferroptosis and blocking the protein expression of GPX4. Furthermore, the treatment with DT was able to inhibit metastasis of A549 cells in a nude mice model without any adverse effects. Further research is needed to validate these findings.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells

Yi Wen et al.

Summary: 18-beta-glycyrrhetinic acid can promote the production of ROS and RNS through activating NADPH oxidases and iNOS, decreasing GSH and GPX activity, subsequently exacerbating lipid peroxidation and triggering ferroptosis in triple-negative breast cancer cells.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Oncology

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ

Jing Cai et al.

Summary: The study reveals that triptolide eliminates head and neck cancer cells through inducing GSDME-mediated pyroptosis, and this effect is achieved by inhibiting HK-II and promoting caspase 3 activation. Combination with the SLC7A11 inhibitor erastin shows a strong synergistic effect in suppressing tumor survival in vitro and in a nude mice model. This research provides new insights into the use of TPL in cancer therapy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Anticancer effects of Cryptotanshinone against lung cancer cells through ferroptosis

Xiaoping Li et al.

Summary: Cryptotanshinone (CTN), a natural compound from the roots of Salvia miltiorrhiza, has been shown to inhibit lung cancer cell growth and invasion, and induce a novel form of cell death called ferroptosis. This iron-dependent cell death involves increased cellular iron content, reduced GPx4 activity, and lipid peroxidation induced by CTN. While caspase-dependent cell death plays a role in CTN-induced cell death, primarily ferroptosis is responsible for around 80% of the observed cell death.

ARABIAN JOURNAL OF CHEMISTRY (2021)

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Article Oncology

Curcumin reverses the sunitinib resistance in clear cell renal cell carcinoma (ccRCC) through the induction of ferroptosis via the ADAMTS18 gene

Ben Xu et al.

Summary: Curcumin combined with sunitinib can reverse the resistance of clear cell renal cell carcinoma to sunitinib, possibly by upregulating the expression of the ADAMTS18 gene to induce ferroptosis.

TRANSLATIONAL CANCER RESEARCH (2021)

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Review Cell Biology

Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation

Zhu-hui Yuan et al.

Summary: This review explores the impact of ionizing radiation on tumor cells, specifically focusing on the changes in fatty acid metabolism and activity, and how regulating FA metabolism can influence the fate of ferroptotic cell death induced by ionizing radiation. Targeting key molecules involved in lipid metabolism and ferroptosis may enhance tumor response to IR.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

A Promising Future of Ferroptosis in Tumor Therapy

Hui Wang et al.

Summary: Ferroptosis, as a form of cell death associated with iron and lipid peroxidation, has attracted extensive attention, with its underlying mechanisms and roles in various tumors being studied. The potential of combined treatment of anti-tumor drugs and radiotherapy holds promise as a new strategy for anti-tumor treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Targeting ferroptosis-based cancer therapy using nanomaterials: and

Lianxiang Luo et al.

Summary: Ferroptosis, as an iron-dependent programmed cell death induced by lipid peroxidation, plays a significant role in cancer therapy. Utilizing nanomaterials targeting ferroptosis shows promise in developing new cancer treatments, but the various design ideas require systematic summaries and new insights for effective clinical application. Further optimization of nanomaterials design is essential to make them suitable for clinical treatment.

THERANOSTICS (2021)

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Review Medicine, Research & Experimental

Targeting iron metabolism in cancer therapy

Michael Morales et al.

Summary: Iron is crucial for cellular functions and human health, but excess iron can lead to oxidative DNA damage and cancer. Cancer cells are more dependent on iron than normal cells, making targeting iron metabolism in cancer cells an emerging and powerful therapeutic strategy.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid

Zongchao Hong et al.

Summary: Colorectal cancer is a deadly malignant tumor, and ferroptosis is considered a potential treatment strategy. Studies have shown that ferroptosis-related genes have prognostic value in CRC, and gallic acid can improve CRC by regulating ferroptosis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, General & Internal

Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity

Wei Wu et al.

Summary: The study demonstrated that ammonium ferric citrate (AFC) can effectively inhibit the proliferation and invasion of lung cancer cells, induce oxidative stress injury, and ferroptosis. AFC exerts its effects by regulating the expression of cell growth factors, negative regulators of ferroptosis, and autophagy regulators.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells

Ruiran Wei et al.

Summary: Colorectal cancer (CRC) is a common malignant tumor and traditional treatments have limited efficacy. Ferroptosis, a form of regulated cell death dependent on iron and reactive oxygen species (ROS), has been studied as a promising way to fight against resistant cancers. This study explored the mechanism of action of tagitinin C (TC), a natural product, as a novel ferroptosis inducer in CRC cells, showing that TC induces ferroptosis through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

Yongfei Yang et al.

NATURE COMMUNICATIONS (2020)

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Review Oncology

Ferroptosis in Cancer Cell Biology

Christina M. Bebber et al.

CANCERS (2020)

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Article Oncology

Fuzheng Kang-Ai decoction enhances the effect of Gefitinib-induced cell apoptosis in lung cancer through mitochondrial pathway

Sumei Wang et al.

CANCER CELL INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma

Chie Ishikawa et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression

Zhuowei Gao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down

Zhenhua Guan et al.

BIOSCIENCE REPORTS (2020)

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Review Biochemistry & Molecular Biology

The function and mechanism of ferroptosis in cancer

Ying Wang et al.

APOPTOSIS (2020)

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Article Pharmacology & Pharmacy

Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition

Meng Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Review Cell Biology

Emerging Mechanisms and Disease Relevance of Ferroptosis

Brent R. Stockwell et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Cell Biology

Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity

Honglin Mei et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Oncology

Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis

Sascha D. Markowitsch et al.

CANCERS (2020)

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Article Pharmacology & Pharmacy

The Inhibitory Effect of 6-Gingerol on Ubiquitin-Specific Peptidase 14 Enhances Autophagy-Dependent Ferroptosis and Anti-Tumor in vivo and in vitro

Yun Tsai et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Oncology

Targeting ferroptosis in breast cancer

Zhaoqing Li et al.

BIOMARKER RESEARCH (2020)

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Article Genetics & Heredity

Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis

Zhichao Xu et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2020)

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Article Biochemistry & Molecular Biology

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis

Peng Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemistry & Molecular Biology

Autophagy-Dependent Ferroptosis: Machinery and Regulation

Jiao Liu et al.

CELL CHEMICAL BIOLOGY (2020)

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Article Medicine, Research & Experimental

Combinative treatment of beta-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation

Peng Chen et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

The interaction between ferroptosis and lipid metabolism in cancer

Dingshan Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Biochemistry & Molecular Biology

The tumor suppressor protein p53 and the ferroptosis network

Rui Kang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Article Plant Sciences

Actinidia chinensis Planch root extract attenuates proliferation and metastasis of hepatocellular carcinoma by inhibiting epithelial-mesenchymal transition

Tingting Fang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Review Oncology

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

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Review Oncology

Targeting Ferroptosis to Iron Out Cancer

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