Journal
NANOSCALE
Volume 8, Issue 9, Pages 5302-5312Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr00450d
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Funding
- National Basic Research Programs of China (973 program) [2013CB127603, 2012CB932504, 2015CB932104]
- National Natural Science Foundation of China [21174012, 51221002, 21574009]
- Beijing Natural Science Foundation [2142026]
- Fundamental Research Funds for the Central Universities [YS201402]
- Innovation and Promotion Project of Beijing University of Chemical Technology
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A novel smart fluorescent drug delivery system composed of a perylene diimide (PDI) core and block copolymer poly(D,L-lactide)-b-poly(ethyl ethylene phosphate) is developed and named as PDI-star-(PLA-b-PEEP)(8). The biodegradable PDI-star-(PLA-b-PEEP)(8) is a unimolecular micelle and can self-assemble into supramolecular micelles, called as fluorescent supramolecular micelles (FSMs), in aqueous media. An insoluble drug camptothecin (CPT) can be effectively loaded into the FSMs and exhibits pH-responsive release. Moreover, the FSMs with good biocompatibility can also be employed as a remarkable fluorescent probe for cell labelling because the maximum emission of PDI is beneficial for bio-imaging. The flow cytometry and confocal laser scanning microscopy analysis demonstrate that the micelles are easily endocytosed by cancer cells. In vitro and in vivo tumor growth-inhibitory studies reveal a better therapeutic effect of FSMs after CPT encapsulation when compared with the free CPT drug. The multifunctional FSM nanomedicine platform as a nanovehicle has great potential for fluorescence imaging-guided cancer therapy.
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