Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 12, Issue 3, Pages 623-632Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2015.10.016
Keywords
Quercetin; PLGA-TPGS; Nanomedicine; Anti-ultraviolet (UV) radiation; Skin disease
Funding
- National Natural Science Foundation of China [31270019]
- Guangdong Natural Science Funds for Distinguished Young Scholar [2014A030306036]
- Scientific and Technological Innovation Bureau of Nanshan District [KC2014JSCX0023A]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20150430163009479, JCYJ20150529164918738, CYZZ 20130320110255352]
- Shenzhen Hong Kong Innovation Circle Research Program [ZYB200907100147A]
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Ultraviolet (UV) radiation has deleterious effects on living organisms, and functions as a tumor initiator and promoter. Multiple natural compounds, like quercetin, have been shown the protective effects on UV-induced damage. However, quercetin is extremely hydrophobic and limited by its poor percutaneous permeation and skin deposition. Here, we show that quercetin-loaded PLGA-TPGS nanoparticles could overcome low hydrophilicity of quercetin and improve its anti-UVB effect. Quercetin-loaded NPs can significantly block UVB irradiation induced COX-2 up-expression and NF-kB activation in Hacat cell line. Moreover, PLGA-TPGS NPs could efficiently get through epidermis and reach dermis. Treatment of mice with quercetin-loaded NPs also attenuates UVB irradiation-associated macroscopic and histopathological changes in mice skin. These results demonstrated that copolymer PLGA-TPGS could be used as drug nanocarriers against skin damage and disease. The findings provide an external use of PLGA-TPGS nanocarriers for application in the treatment of skin diseases. (C) 2015 Elsevier Inc. All rights reserved.
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