Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 12, Issue 5, Pages 1397-1407Publisher
ELSEVIER
DOI: 10.1016/j.nano.2016.01.009
Keywords
Bionanotechnology; Self-assembly; Cancer; Supramolecular materials; Hydrogels; Tissue engineering
Funding
- Australian Research Council (ARC) Discovery Project [DP130103131]
- ARC [LE110100141]
- NHMRC Career Development Fellowship [APP1050684]
- Alfred Deakin Research Fellowship
- Australian Microscopy and Microanalysis Research Facility (AMMRF)
- Swedish Research Council VR
- Institut Laue-Langevin user access programme [8-03-826]
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The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti- inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery. (C) 2016 Elsevier Inc. All rights reserved.
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