Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 12, Issue 7, Pages 1919-1929Publisher
ELSEVIER
DOI: 10.1016/j.nano.2016.05.005
Keywords
Cisplatin delivery; Cancer chemotherapy; Nanoparticle; Electrohydrodynamic atomization; Controlled release
Funding
- EPSRC [EP/L026287/1, EP/L025825/1]
- EPSRC [EP/L026287/1, EP/L025825/1] Funding Source: UKRI
- Cancer Research UK [21030] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/L025825/1, EP/L026287/1] Funding Source: researchfish
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Targeted delivery of potent, toxic chemotherapy drugs, such as cisplatin, is a significant area of research in cancer treatment. In this study, cisplatin was successfully encapsulated with high efficiency ( >70%) in poly ( lactic-co-glycolic acid) polymeric nanoparticles by using electrohydrodynamic atomization ( EHDA) where applied voltage and solution flow rate as well as the concentration of cisplatin and polymer were varied to control the size of the particles. Thus, nanoparticles were produced with three different drug: polymer ratios ( 2.5, 5 and 10 wt% cisplatin). It was shown that smaller nanoparticles were produced with 10 wt% cisplatin. Furthermore, these demonstrated the best sustained release ( smallest burst release). By fitting the experimental data with various kinetic models it was concluded that the release is dependent upon the particle morphology and the drug concentration. Thus, these particles have significant potential for cisplatin delivery with controlled dosage and release period that are crucial chemotherapy parameters. (C) 2016 The Authors. Published by Elsevier Inc.
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