Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 12, Issue 3, Pages 735-744Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2015.10.008
Keywords
Caenorhabditis elegans; Glycyrrhizae radix; Glycyrrhizic acid; Prevention; Graphene oxide; MicroRNAs; Nanotoxicity
Funding
- National Basic Research Program of China [2011CB933404]
- National Natural Science Foundation of China [81172698]
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We investigated effects of pretreatment with Glycyrrhizae radix (GR) or its specific components on toxicity of graphene oxide (GO) in Caenorhabditis elegans. GR pretreatment prevented GO toxicity on function of both primary and secondary targeted organs. Among active components in GR, the beneficial effects of GR were attributable to presence of glycyrrhizic acid. Glycyrrhizic acid pretreatment suppressed translocation of GO into secondary targeted organs through intestinal barrier. Glycyrrhizic acid pretreatment recovered expression patterns of dysregulated microRNAs (miRNAs) induced by GO, and genes required for oxidative stress control acted as targeted genes for some of these miRNAs. Among these miRNAs, mir-360 mutation enhanced beneficial effects of glycyrrhizic acid. We hypothesize that glycyrrhizic acid may prevent GO toxicity and translocation by influencing functions of miRNAs which upstream regulate functions of their targeted genes. Furthermore, glycyrrhizic acid had potential to extend lifespan, and to suppress accelerated aging process induced by GO.
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