4.6 Review

Building the synaptonemal complex: Molecular interactions between the axis and the central region

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3

James H. Crichton et al.

Summary: During meiosis, the synaptonemal complex (SC), a supramolecular protein structure, forms between homologous chromosomes to aid in recombination. In mammals, SC formation involves the hierarchical assembly of an SYCP1 protein lattice. However, our study shows that the CE protein SYCE3 actively remodels the SYCP1 lattice during synapsis, rather than stabilizing it. SYCE3 interacts with other CE complexes and establishes a new lattice, leading to long-range synapsis and the formation of a mature SC.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2023)

Article Cell Biology

Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly

Michael G. Pollard et al.

Summary: The synaptonemal complex (SC) is a structure formed during meiosis that stabilizes and supports essential processes such as pairing and recombination. This study measured the assembly and disassembly kinetics of the SC protein Zip1 in live cells of S. cerevisiae. It was found that SC assembly occurs with both monophasic and biphasic kinetics, and there are distinct disassembly events termed abortive disassembly. These findings provide new insights into the regulation of SC assembly and disassembly.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

Review Biochemistry & Molecular Biology

Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling

Yajie Gu et al.

Summary: Controlled assembly and disassembly of multi-protein complexes play a critical role in cellular signaling. HORMA proteins, through their ability to adopt multiple conformational states, nucleate signaling complexes and are involved in various cellular pathways. Pch2/TRIP13, a regulator of HORMA proteins, manipulates their conformational states to activate or inactivate signaling in different cellular contexts, making it a potential therapeutic target.

ANNUAL REVIEW OF BIOCHEMISTRY (2022)

Article Biochemistry & Molecular Biology

On the role of phase separation in the biogenesis of membraneless compartments

Andrea Musacchio

Summary: Molecular mechanistic biology has delved into the basic building blocks of life, uncovering their interactions and proposing strategies for biological processes. The concept of biomolecular phase separation emphasizes the driving force of interactions, but its validation is challenging. Highly specific interactions may be the main driver of subcellular compartment formation, while phase separation can be locally utilized in specific instances.

EMBO JOURNAL (2022)

Article Biochemistry & Molecular Biology

Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae

Jonna Heldrich et al.

Summary: Successful meiotic recombination requires conserved axis proteins, which distribute on chromosomes through two independent pathways: a cohesin-dependent pathway and a cohesin-independent pathway. These pathways result in a stereotypic distribution pattern and the formation of chromatin islands that influence chromosome structure.

NUCLEIC ACIDS RESEARCH (2022)

Review Genetics & Heredity

Functions and Regulation of Meiotic HORMA-Domain Proteins

Josh P. Prince et al.

Summary: During meiosis, the HORMADs protein family plays a crucial role in regulating key events. This review summarizes the protein complexes formed by HORMADs and discusses their functions and mechanisms in meiosis, providing possible directions for future research.

GENES (2022)

Review Multidisciplinary Sciences

Capillary forces generated by biomolecular condensates

Bernardo Gouveia et al.

Summary: Liquid-liquid phase separation and related phase transitions are generic mechanisms in living cells for the formation of membraneless compartments or biomolecular condensates, bridging the fields of cell biology and soft matter physics.

NATURE (2022)

Article Biochemistry & Molecular Biology

Heterologous synapsis in C. elegans is regulated by meiotic double-strand breaks and crossovers

Hanwenheng Liu et al.

Summary: Alignment of parental chromosomes during meiotic prophase is crucial for genetic exchanges. In C. elegans, reduced levels of meiotic double-strand breaks or crossovers lead to increased heterologous synapsis, suggesting regulation by break formation or repair, as well as chromosome-specific and nucleus-wide regulation.

CHROMOSOMA (2021)

Article Physics, Multidisciplinary

A hydrodynamic instability drives protein droplet formation on microtubules to nucleate branches

Sagar U. Setru et al.

Summary: Liquid-liquid phase separation not only occurs in bulk liquid, but also on surfaces. In this study, it was found that the protein TPX2 on microtubules reorganizes according to the Rayleigh-Plateau instability to initiate branching microtubule nucleation. The spacing of droplets formed by TPX2 increases with higher TPX2 concentration, making branching nucleation more efficient by confining necessary factors in a smaller space along the microtubule.

NATURE PHYSICS (2021)

Article Multidisciplinary Sciences

ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis

Martin G. France et al.

Summary: The study on the function of the synaptonemal complex in Arabidopsis indicates that it limits the formation of Class I crossover interference and disrupts the progressive alignment of chromosome axes in plants.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Genetics & Heredity

Architecture and Dynamics of Meiotic Chromosomes

Sarah N. Ur et al.

Summary: Meiotic cell division is a specialized process preparing for sexual reproduction, involving homologous chromosomes identifying each other and forming physical links through DNA recombination. The SMC family cohesin complexes and meiotic chromosome axis play crucial roles in organizing chromosomes and promoting recombination. The synaptonemal complex (SC) ensures high fidelity in meiotic recombination by assembling between homologs and providing feedback.

ANNUAL REVIEW OF GENETICS, VOL 55 (2021)

Article Multidisciplinary Sciences

Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis

Chris Morgan et al.

Summary: Through quantitative super-resolution cytogenetics and mathematical modeling, this study investigated crossover positioning in Arabidopsis thaliana and found that the process can be explained by a predictive coarsening model. Altering the dosage of the E3 ligase HEI10 was shown to predictably modify crossover interference, suggesting a conserved mechanism may regulate crossover positioning in diverse eukaryotes.

NATURE COMMUNICATIONS (2021)

Review Genetics & Heredity

Alternative Synaptonemal Complex Structures: Too Much of a Good Thing?

Stacie E. Hughes et al.

TRENDS IN GENETICS (2020)

Article Multidisciplinary Sciences

X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance

Katherine Kretovich Billmyre et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Genetics & Heredity

Organization of Chromosomal DNA by SMC Complexes

Stanislau Yatskevich et al.

Annual Review of Genetics (2019)

Article Biochemistry & Molecular Biology

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2

Alan M. V. West et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly

James M. Dunce et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Plant Sciences

Identification of ASYNAPTIC4, a Component of the Meiotic Chromosome Axis

Aurelie Chambon et al.

PLANT PHYSIOLOGY (2018)

Review Genetics & Heredity

Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics

Jinmin Gao et al.

TRENDS IN GENETICS (2018)

Article Biochemistry & Molecular Biology

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly

James M. Dunce et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

Yongdae Shin et al.

Article Multidisciplinary Sciences

Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intact Caenorhabditis elegans tissue

Simone Koehlera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin

Jeffrey B. Woodruff et al.

Review Genetics & Heredity

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

Stephen Gray et al.

ANNUAL REVIEW OF GENETICS, VOL 50 (2016)

Article Evolutionary Biology

Holding it together: rapid evolution and positive selection in the synaptonemal complex of Drosophila

Lucas W. Hemmer et al.

BMC EVOLUTIONARY BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Regulating the construction and demolition of the synaptonemal complex

Cori K. Cahoon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Cell Biology

Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans

Zhouliang Yu et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Article Multidisciplinary Sciences

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

Laura Gomez-H et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Regulating the construction and demolition of the synaptonemal complex

Cori K. Cahoon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Cell Biology

Recombination, Pairing, and Synapsis of Homologs during Meiosis

Denise Zickler et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Cell Biology

Direct Visualization Reveals Kinetics of Meiotic Chromosome Synapsis

Ofer Rog et al.

CELL REPORTS (2015)

Article Genetics & Heredity

Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers

Christophe Lambing et al.

PLOS GENETICS (2015)

Review Cell Biology

Liquid-Liquid Phase Separation in Biology

Anthony A. Hyman et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Multidisciplinary Sciences

Meiotic chromosome structures constrain and respond to designation of crossover sites

Diana E. Libuda et al.

NATURE (2013)

Article Multidisciplinary Sciences

Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans

Johanna Fraune et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Genetics & Heredity

Full-Length Synaptonemal Complex Grows Continuously during Meiotic Prophase in Budding Yeast

Karen Voelkel-Meiman et al.

PLOS GENETICS (2012)

Article Biochemistry & Molecular Biology

A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes

Nikhila S. Tanneti et al.

CURRENT BIOLOGY (2011)

Article Biochemistry & Molecular Biology

The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility

Yurema Herran et al.

EMBO JOURNAL (2011)

Article Genetics & Heredity

Organization of the Synaptonemal Complex During Meiosis in Caenorhabditis elegans

Kristina Schild-Pruefert et al.

GENETICS (2011)

Article Multidisciplinary Sciences

The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I

Louise Newnham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1

Christian S. Eichinger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1

Alexandra M. Penkner et al.

Article Cell Biology

The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing

Gloria A. Brar et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Multidisciplinary Sciences

Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis

G. Valentin Boerner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex

LK Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Cell Biology

The cohesion protein ORD is required for homologue bias during meiotic recombination

HA Webber et al.

JOURNAL OF CELL BIOLOGY (2004)

Review Cell Biology

The genetics and molecular biology of the synaptonemal complex

SL Page et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila

EA Manheim et al.

CURRENT BIOLOGY (2003)

Review Biochemistry & Molecular Biology

Brownian ratchet models of molecular motors

R Ait-Haddou et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2003)

Article Cell Biology

c(3)G encodes a Drosophila synaptonemal complex protein

SL Page et al.

GENES & DEVELOPMENT (2001)

Article Cell Biology

Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I

I Prieto et al.

NATURE CELL BIOLOGY (2001)