Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 12, Issue 5, Pages 1185-1192Publisher
ELSEVIER
DOI: 10.1016/j.nano.2016.01.021
Keywords
Silver nanoparticles; Antivirals; Rift Valley fever virus; In vivo infection
Funding
- CONACYT from Mexico [244208, 260409]
- Spanish Ministry of Science [AGL2011-22485, AGL-2014-57430R]
- Government Program Science of Tomsk Polytechnic University, Russia [4.1187.2014/K]
- [PAPIIT-UNAMIT200114]
Ask authors/readers for more resources
In this work we have tested the potential antiviral activity of silver nanoparticles formulated as Argovit (TM) against Rift Valley fever virus (RVFV). The antiviral activity of Argovit was tested on Vero cell cultures and in type-I interferon receptor deficient mice (IFNAR(-/-) mice) by two different approaches: (i) different dilutions of Argovit were added to previously infected cells or administrated to animals infected with a lethal dose of virus; (ii) virus was pre-incubated with different dilutions of Argovit before inoculation in mice or cells. Though the ability of silver nanoparticles to control an ongoing RVFV infection in the conditions tested was limited, the incubation of virus with Argovit before the infection led to a reduction of the infectivity titers both in vitro and in vivo. These results reveal the potential application of silver nanoparticles to control the infectivity of RVFV, which is an important zoonotic pathogen. (C) 2016 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available