Journal
MOLECULAR BRAIN
Volume 16, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13041-023-01052-8
Keywords
Insular cortex; Anterior cingulate cortex; Neuropathic pain; Neural projection; Optogenetics
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This study found inhibitory neurons projecting from the posterior insula to the anterior cingulate cortex, and stimulation of these projections did not affect mechanical nociception but induced affective responses.
The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in neuropathic pain states. Here, we aimed to study inhibitory parvalbumin positive (PV+) posterior insula (pIC) to posterior ACC (pACC) projections, and to evaluate the effects of direct optogenetic manipulation of such projections on mechanical nociception and spontaneous ongoing pain in mice with Spared Nerve Injury (SNI). CTB488 tract-tracing in male PVCrexAi9 mice revealed a small proportion of PV+ projections from the pIC to the pACC. Electrophysiological analysis confirmed the existence of synaptic inputs into the pACC by pIC GABAergic cells. Optogenetic stimulation of these pathways did not change mechanical nociception, but induced conditioned place preference behavior responses. Our results suggest the presence of inhibitory projections between the pIC and the pACC which are able to selectively modulate affective aspects of neuropathic pain.
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