4.6 Article

Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators

Related references

Note: Only part of the references are listed.
Article Immunology

Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages

Arturo Gonzalez de la Aleja et al.

Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.

FRONTIERS IN IMMUNOLOGY (2022)

Review Gastroenterology & Hepatology

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

Kiarash Riazi et al.

Summary: The prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) are significantly increasing worldwide, with higher rates in men compared to women. Greater awareness and cost-effective risk stratification strategies are needed to address the growing burden of NAFLD.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Review Immunology

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Yankai Wen et al.

Summary: Macrophages, key cellular components of the liver, play essential roles in maintaining liver homeostasis, injury and repair processes in liver diseases. Kupffer cells and monocyte-derived macrophages contribute significantly to tissue inflammation and injury, but exhibit different functional responses in distinct liver diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease

Danshan Gu et al.

Summary: The study indicated that ginsenoside-Rg1 showed potential efficacy in improving NAFLD by enhancing liver function, alleviating pathology process, and identifying key genes Atf3 and Acox2 through transcriptome analysis.

LIFE SCIENCES (2021)

Article Agriculture, Multidisciplinary

Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway

Jing Zhou et al.

Summary: Ginsenoside F2 (GF2) may prevent obesity by inhibiting adipocyte differentiation through regulating adipokines and activating the AMPK pathway, resulting in reduced body weight gain and adipose tissue weight in obese mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway

Da Eun Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Immunology

Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer

Maria Teresa Bilotta et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Gastroenterology & Hepatology

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Konstantin Kazankov et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Liver X receptors in lipid signalling and membrane homeostasis

Bo Wang et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice

Seol-Hee Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Medicine, General & Internal

Nonalcoholic fatty liver disease

Elizabeth M. Brunt et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Pharmacology & Pharmacy

The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin

Heon-Sub Shin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

Review Cell Biology

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Anna C. Calkin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Plant Sciences

Anti-Cancer Effect of Ginsenoside F2 against Glioblastoma Multiforme in Xenograft Model in SD Rats

Ji Yon Shin et al.

JOURNAL OF GINSENG RESEARCH (2012)

Review Biochemistry & Molecular Biology

Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

Noelia A-Gonzalez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Pharmacology & Pharmacy

Ginseng Compounds: An Update on their Molecular Mechanisms and Medical Applications

Jian-Ming Lue et al.

CURRENT VASCULAR PHARMACOLOGY (2009)

Article Endocrinology & Metabolism

Putative metabolic effects of the liver x receptor (LXR)

KR Steffensen et al.

DIABETES (2004)

Article Biochemistry & Molecular Biology

The role of liver X receptor-α in the fatty acid regulation of hepatic gene expression

A Pawar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)