Journal
NANOMEDICINE
Volume 11, Issue 24, Pages 3237-3259Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0220
Keywords
angiogenesis; cardiovascular; controlled release; nanoparticles; regenerative medicine; tissue engineering
Funding
- Canadian Institutes of Health Research (CIHR)
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Aim: Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release. Materials & methods: Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles. Results: The bilayer nanoparticles featured low burst effect and time-delayed release, and allowed for sequential release of PDGF following co-release of VEGFand bFGF, which promoted angiogenesis. Conclusion: The nanoparticulate delivery system, along with the Geno-Neural model, offers great potential for spatiotemporal control of GF release for cardiovascular regenerative medicine.
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