Journal
NANOMEDICINE
Volume 11, Issue 11, Pages 1417-1430Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0040
Keywords
autophagy; autophagy-modulating effect; nanomaterials
Funding
- National Natural Science Foundation of China [31400853]
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Autophagy is an essential lysosome-dependent process that controls the quality of the cytoplasm and maintains cellular homeostasis, and dysfunction of this protein degradation system is correlated with various disorders. A growing body of evidence suggests that nanomaterials (NMs) have autophagy-modulating effects, thus predicting a valuable and promising application potential of NMs in the diagnosis and treatment of autophagy-related diseases. NMs exhibit unique physical, chemical and biofunctional properties, which may endow NMs with capabilities to modulate autophagy via various mechanisms. The present review highlights the impacts of various NMs on autophagy and their functional consequences. The possible underlying mechanisms for NM-modulated autophagy are also discussed.
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