Journal
NANOMEDICINE
Volume 11, Issue 3, Pages 289-306Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.203
Keywords
gemini-DNA interactions cellular barriers; gemini surfactants; nonviral gene therapy; transfection efficiency
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canadian Foundation for Innovation
- Ontario Ministry of Research and Innovation
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Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can be adapted toward the treatment of various diseases. Recently, gemini surfactants have been utilized as candidates for the formation of nonviral vectors. The chemical structure of the surfactant (variations in the alkyl tail length and spacer/head group) and the resulting physicochemical properties of the lipoplexes are critical parameters for efficient gene transfection. Moreover, studying the interaction of the surfactant with DNA can help in designing an efficient vector and understanding how transfection complexes overcome various cellular barriers. Part I of this review provides an overview of various types of gemini surfactants designed for gene therapy and their transfection efficiency; and Part II will focus on different novel methods utilized to understand the interactions between the gemini and DNA in a lipoplex.
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