4.6 Article

Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population

Related references

Note: Only part of the references are listed.
Article Geriatrics & Gerontology

Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset

Jan Homann et al.

Summary: Alzheimer's disease is a neurodegenerative disease that is becoming more common in industrialized and aging populations. This study used quantitative AD-related phenotypes as outcome traits in GWAS analyses and identified several new loci associated with cognitive decline.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Article Clinical Neurology

Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia A Secondary Analysis of the Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Cohort Study

Consuelo H. Wilkins et al.

Summary: This study compares the amyloid PET positivity among a diverse cohort of individuals with mild cognitive impairment or dementia. The results show racial and ethnic differences in amyloid PET positivity, with lower odds observed in Asian, Black, and Hispanic participants compared to White participants.

JAMA NEUROLOGY (2022)

Article Clinical Neurology

Amyloid Positivity in the Alzheimer/Subcortical-Vascular Spectrum

Sung Hoon Kang et al.

Summary: The study found that the prevalence of Aβ positivity increased with the severity of cognitive impairment, but decreased with the severity of white matter hyperintensities. Aβ positivity was associated with higher education, absence of diabetes, and presence of APOE ε4.

NEUROLOGY (2021)

Article Clinical Neurology

Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population

Hang-Rai Kim et al.

Summary: This study identified novel genetic variants associated with a decreased risk of A beta positivity in the Korean population, providing a potential therapeutic target for AD and emphasizing the importance of genetic studies in diverse populations.

ALZHEIMERS RESEARCH & THERAPY (2021)

Article Clinical Neurology

Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study

Kacie D. Deters et al.

Summary: This study found differences in amyloid PET between non-Hispanic White and Black participants who passed initial screening for the A4 study, with lower amyloid levels observed in Black participants. The effect of race on amyloid was strongest in the APOE epsilon 4 group, and within Black participants, those with lower percentage of African ancestry had higher amyloid levels.

NEUROLOGY (2021)

Article Multidisciplinary Sciences

Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer's Disease

Samar S. M. Elsheikh et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

Yuxing Liao et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Neurosciences

Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease

Niraj M. Shanbhag et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Clinical Neurology

Axonal transport and neurological disease

James N. Sleigh et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Clinical Neurology

Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis

Liana G. Apostolova et al.

JAMA NEUROLOGY (2018)

Article Genetics & Heredity

Next-generation genotype imputation service and methods

Sayantan Das et al.

NATURE GENETICS (2016)

Article Geriatrics & Gerontology

Assessment of the genetic variance of late-onset Alzheimer's disease

Perry G. Ridge et al.

NEUROBIOLOGY OF AGING (2016)

Article Clinical Neurology

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

William E. Klunk et al.

ALZHEIMERS & DEMENTIA (2015)

Article Genetics & Heredity

Understanding multicellular function and disease with human tissue-specific networks

Casey S. Greene et al.

NATURE GENETICS (2015)

Article Clinical Neurology

Genome-wide association study of the rate of cognitive decline in Alzheimer's disease

Richard Sherva et al.

ALZHEIMERS & DEMENTIA (2014)

Article Biochemistry & Molecular Biology

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

V. K. Ramanan et al.

MOLECULAR PSYCHIATRY (2014)

Article Neurosciences

Genetic variability in the regulation of gene expression in ten regions of the human brain

Adaikalavan Ramasamy et al.

NATURE NEUROSCIENCE (2014)

Editorial Material Multidisciplinary Sciences

Mitochondria impact brain function and cognition

Martin Picard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Genetics & Heredity

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert et al.

NATURE GENETICS (2013)

Review Neurosciences

Axonal transport deficits and neurodegenerative diseases

Stephanie Millecamps et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Article Clinical Neurology

PP2A and Alzheimer Disease

L. Torrent et al.

CURRENT ALZHEIMER RESEARCH (2012)

Article Genetics & Heredity

Genome-wide and gene-based association implicates FRMD6 in alzheimer disease

Mun-Gwan Hong et al.

HUMAN MUTATION (2012)

Article Multidisciplinary Sciences

Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

Alvaro O. Ardiles et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Genetics & Heredity

GATES: A Rapid and Powerful Gene-Based Association Test Using Extended Simes Procedure

Miao-Xin Li et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Review Biochemistry & Molecular Biology

Brain aging, Alzheimer's disease, and mitochondria

Russell H. Swerdlow

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Article Medicine, Research & Experimental

Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Article Clinical Neurology

Tau in Alzheimer Disease and Related Tauopathies

K. Iqbal et al.

CURRENT ALZHEIMER RESEARCH (2010)

Review Multidisciplinary Sciences

Neural mechanisms of ageing and cognitive decline

Nicholas A. Bishop et al.

NATURE (2010)

Article Genetics & Heredity

Common SNPs explain a large proportion of the heritability for human height

Jian Yang et al.

NATURE GENETICS (2010)

Article Biochemistry & Molecular Biology

GSA-SNP: a general approach for gene set analysis of polymorphisms

Dougu Nam et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Statistics & Probability

Identification, Inference and Sensitivity Analysis for Causal Mediation Effects

Kosuke Imai et al.

STATISTICAL SCIENCE (2010)

Review Multidisciplinary Sciences

Finding the missing heritability of complex diseases

Teri A. Manolio et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Effects of cell cycle inhibitors on tau phosphorylation in N2aTau3R cells

Concepcion Conejero-Goldberg et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2008)

News Item Multidisciplinary Sciences

Personal genomes: The case of the missing heritability

Brendan Maher

NATURE (2008)

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Article Psychiatry

Role of genes and environments for explaining Alzheimer disease

M Gatz et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)

Review Psychiatry

The endophenotype concept in psychiatry: Etymology and strategic intentions

II Gottesman et al.

AMERICAN JOURNAL OF PSYCHIATRY (2003)

Review Geriatrics & Gerontology

Inflammation and Alzheimer's disease

H Akiyama et al.

NEUROBIOLOGY OF AGING (2000)