Journal
NANOMEDICINE
Volume 11, Issue 1, Pages 63-79Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm.15.186
Keywords
antibody conjugation; cancer therapy; multifunctional nanoparticles; nanomedicines; targeted delivery
Funding
- School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
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The use of nanotechnology has great potentials to revolutionize the future cancer diagnosis and therapy. In this context, various nanoparticles (NPs) have been developed for targeted delivery of diagnostic/therapeutic agents to the tumor sites, which thus result in greater efficacy and much less side effects. The targeting property of NPs is often achieved by functionalizing their surface with tumor-specific ligands, such as antibodies, peptides, small molecules and oligonucleotides. In this review, we will discuss recent progress in the multifunctional design of antibody-targeted NPs with a special focus on liposomal, polymeric and protein-based delivery systems.
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