Prebiotic Vitamin B3 Synthesis in Carbonaceous Planetesimals

Aqueous chemistry within carbonaceous planetesimals is promising for synthesizing prebiotic organic matter essential to all life. Meteorites derived from these planetesimals delivered these life building blocks to the early Earth, potentially facilitating the origins of life. Here, we studied the formation of vitamin B-3 as it is an important precursor of the coenzyme NAD(P)(H), which is essential for the metabolism of all life as we know it. We propose a new reaction mechanism based on known experiments in the literature that explains the synthesis of vitamin B-3. It combines the sugar precursors glyceraldehyde or dihydroxyacetone with the amino acids aspartic acid or asparagine in aqueous solution without oxygen or other oxidizing agents. We performed thermochemical equilibrium calculations to test the thermodynamic favorability. The predicted vitamin B-3 abundances resulting from this new pathway were compared with measured values in asteroids and meteorites. We conclude that competition for reactants and decomposition by hydrolysis are necessary to explain the prebiotic content of meteorites. In sum, our model fits well into the complex network of chemical pathways active in this environment.

Automated summary

This study investigates aqueous chemistry within carbonaceous planetesimals and proposes a new reaction mechanism for the synthesis of vitamin B-3. Through experiments and thermodynamic calculations, the study examines the favorability of this new pathway and compares the predicted vitamin B-3 abundances with measured values in asteroids and meteorites. The findings highlight the importance of understanding prebiotic organic matter formation in meteorites.