4.8 Article

S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway

Atsuko Deguchi et al.

Summary: Tumor-elicited inflammation is linked to tumor microenvironment and S100A8, an endogenous ligand of TLR4, plays a crucial role in this process. A novel multivalent S100A8 inhibitory peptide (divalent peptide3A5) was developed, which suppressed S100A8-mediated cytokine production and inhibited tumor growth in colorectal tumor models. Combination therapy with divalent peptide3A5 and bevacizumab showed synergistic effects. Furthermore, a screening of multivalent peptide library identified more candidates with inhibitory activities against TLR4/MD-2 and anti-tumoral effects. These multivalent S100A8 inhibitory peptides could be potential pharmaceutical options for aggressive cancers.

CANCER GENE THERAPY (2023)

Article Endocrinology & Metabolism

Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes

Kathryn C. S. Locker et al.

Summary: TLR4-Ab reverses acute type 1 diabetes by inducing myeloid-derived suppressor cells (MDSCs). The treatment increases the percentages and numbers of CD11b(+) cells, which can suppress T cells. TLR4-Ab remains sequestered in endosomes for a longer time, altering TLR4 signaling and downregulating inflammatory genes and proteins.

DIABETES (2022)

Article Oncology

PMN-MDSCs accumulation induced by CXCL1 promotes CD8+ T cells exhaustion in gastric cancer

Xingyu Zhou et al.

Summary: This study identified the inducer CXCL1 for PMN-MDSCs accumulation in gastric cancer and revealed how PMN-MDSCs promoted CD8+ T cell exhaustion, providing a potential therapeutic strategy for gastric cancer.

CANCER LETTERS (2022)

Article Chemistry, Multidisciplinary

Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes

Antonella Russo et al.

Summary: It has been demonstrated that S100A8/S100A9 tetramers can weaken the inflammatory response of leukocytes in vitro and in vivo, and this is mediated by the interaction between S100A8/S100A9 tetramers and CD69, rather than the binding of S100A8/S100A9 dimers to TLR4. These findings reveal the important role of the quaternary structure of S100 proteins in regulating leukocyte inflammatory responses.

ADVANCED SCIENCE (2022)

Article Cell Biology

Evaluation of autophagy mediators in myeloid-derived suppressor cells during human tuberculosis

Leigh A. Kotze et al.

Summary: During active TB disease, untreated cases show a significant increase in MDSC frequency, with these MDSC expressing TLR4 and higher levels of mTOR and IL-6 compared to healthy controls. However, mTOR levels decrease during anti-TB therapy, along with a decrease in HMGB1 serum concentrations. This suggests a complex interplay between MDSC and autophagic mediators, potentially dependent on cellular localization and M.tb infection state.

CELLULAR IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

S100A8 may govern hyper-inflammation in severe COVID-19

Atsuko Deguchi et al.

Summary: This study investigates the potential role of S100A8 in COVID-19-associated ARDS and proposes a treatment method. Pathological similarities, clinical information, and experimental results collectively support the importance of S100A8 in COVID-19.

FASEB JOURNAL (2021)

Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Interactions between tumor-derived proteins and Toll-like receptors

Gun-Young Jang et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Immunology

Resolution of inflammation in arthritis

Georg Schett

SEMINARS IN IMMUNOPATHOLOGY (2019)

Article Biotechnology & Applied Microbiology

The role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells?

Misagh Rajabinejad et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Article Medicine, Research & Experimental

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

Thomas Vogl et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, General & Internal

Pathogenetic insights from the treatment of rheumatoid arthritis

Iain B. McInnes et al.

LANCET (2017)

Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

Review Pharmacology & Pharmacy

S100A8/A9: From basic science to clinical application

Monika Pruenster et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Review Immunology

Myeloid-Derived Suppressor Cells in Bacterial Infections

Michael Ost et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2016)

Review Medicine, Research & Experimental

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

Thomas Condamine et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Article Multidisciplinary Sciences

Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

Thomas Vogl et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis

Beatrix Petersen et al.

EMBO JOURNAL (2013)

Review Cell Biology

Treating Human Autoimmunity: Current Practice and Future Prospects

Michael D. Rosenblum et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Review Immunology

Myeloid derived suppressor cells in human diseases

Tim F. Greten et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2011)

Review Medicine, General & Internal

MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis

Iain B. McInnes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Medicine, Research & Experimental

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

Jose M. Gonzalez-Navajas et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

Karin Loser et al.

NATURE MEDICINE (2010)

Review Immunology

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

Suzanne Ostrand-Rosenberg et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Biochemical Research Methods

Protocol for the induction of arthritis in C57BL/6 mice

Julia J. Inglis et al.

NATURE PROTOCOLS (2008)

Article Immunology

Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling

Alexandra Zanin-Zhorov et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Biochemical Research Methods

Collagen-induced arthritis

David D. Brand et al.

NATURE PROTOCOLS (2007)

Review Immunology

Imbalance of regulatory T cells in human autoimmune diseases

C Dejaco et al.

IMMUNOLOGY (2006)