4.8 Article

VEGFR3 is required for button junction formation in lymphatic vessels

Related references

Note: Only part of the references are listed.
Article Peripheral Vascular Disease

Unique functions for Notch4 in murine embryonic lymphangiogenesis

Ajit Muley et al.

Summary: Research in mice has revealed distinct roles for Notch4 signaling versus canonical Notch signaling in embryonic dermal lymphangiogenesis. Notch4 activation suppresses LEC migration more effectively than Notch1, while canonical Notch signaling affects LEC proliferation. These findings highlight the different functions of Notch4 signaling and canonical Notch signaling in coordinating lymphatic development.

ANGIOGENESIS (2022)

Article Immunology

Infection-induced lymphatic zippering restricts fluid transport and viral dissemination from skin

Madeline J. Churchill et al.

Summary: Infection-induced changes in lymphatic transport actively contribute to innate host defense by limiting viral dissemination and promoting antiviral CD8(+) T cell responses.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Article Medicine, Research & Experimental

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Emilia A. Korhonen et al.

Summary: This study reveals the involvement of Ang2 in VEGF-C-induced lymphangiogenesis through the PI3K/Akt signaling pathway in lymphatic endothelial cells. Blockade of Ang2 or deletion of Tie receptors in LECs inhibits lymphangiogenesis. The study highlights the important crosstalk between VEGF-C and Ang signaling pathways and suggests potential therapeutic approaches targeting Ang2/Tie/PI3K signaling for lymphangiogenesis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Genetics & Heredity

FLT4 Mutations Are Associated with Segmental Lymphatic Dysfunction and Initial Lymphatic Aplasia in Patients with Milroy Disease

Ningfei Liu et al.

Summary: This study investigated mutations in the FLT4 gene and lymphatic defects in patients with Milroy disease. Most cases were familial MD, with variable clinical manifestations and genetic mutations.

GENES (2021)

Article Medicine, General & Internal

Primary lymphoedema

Pascal Brouillard et al.

Summary: Lymphoedema is the swelling caused by lymph accumulation in the extracellular space, often chronic and resulting in reduced quality of life if untreated. Primary lymphoedema (PLE) is believed to have a genetic origin, with mutations in genes affecting lymphatic system development; diagnosis relies on clinical presentation, imaging, and genetic analyses, while management includes compression therapy and surgical techniques. Improved understanding of the genetic origins of PLE will lead to more accurate diagnosis and personalized treatment options for affected individuals.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Cardiac & Cardiovascular Systems

Advances in Lymphedema

Stanley G. Rockson

Summary: In recent years, significant advancements have been made in the research and clinical approaches to lymphedema, particularly focusing on genetics, lymphatic imaging, and lymphatic surgery. New molecular insights and the relationships between lymphedema, obesity, and other comorbidities have been explored, providing valuable information for current and future responses to patients with lymphedema.

CIRCULATION RESEARCH (2021)

Article Physiology

VE-Cadherin and Vesicles Differentially Regulate Lymphatic Vascular Permeability to Solutes of Various Sizes

Melanie Jannaway et al.

Summary: The study found that lymphatic vessel permeability is inversely related to solute molecular weight, with vesicles selectively transporting BSA while adherens junctions did not exhibit selectivity for solutes tested. Disruption of VE-cadherin binding significantly increased permeability to smaller solutes, suggesting disease states affecting VE-cadherin could lead to leakage of solutes and fluid from the lymphatic vasculature.

FRONTIERS IN PHYSIOLOGY (2021)

Article Medicine, Research & Experimental

Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction

T. C. Stevenson Keller et al.

Summary: Recent studies have shown that promoting lymphatic growth post-MI does not significantly improve cardiac function, refuting the contribution of lymphangiogenesis to heart function and suggesting that the effect of exogenous VEGF-C is likely mediated by nonlymphangiogenic mechanisms.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, Research & Experimental

Foxo1 deletion promotes the growth of new lymphatic valves

Joshua P. Scallan et al.

Summary: Research identified Foxo1 as a key transcription factor repressing lymphatic valve formation, deletion of which promoted valve formation. Rescue experiments and quantitative analysis confirmed that deletion of Foxo1 completely restored lymphatic valve number and function. These findings establish Foxo1 as a new clinical target for treating patients with congenital lymphedema.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Cell Biology

Characterization of ANGPT2 mutations associated with primary lymphedema

Veli-Matti Leppanen et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Article Cell Biology

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance

Ying Yang et al.

CELL REPORTS (2019)

Article Multidisciplinary Sciences

Lacteal junction zippering protects against diet-induced obesity

Feng Zhang et al.

SCIENCE (2018)

Article Cell Biology

Leukotriene B4 antagonism ameliorates experimental lymphedema

Wen Tian et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling

Krista Heinolainen et al.

CIRCULATION RESEARCH (2017)

Article Medicine, Research & Experimental

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport

Jeremiah Bernier-Latmani et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Medicine, Research & Experimental

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Amelie Sabine et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Rui Benedito et al.

NATURE (2012)

Article Medicine, Research & Experimental

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

Eleni Bazigou et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Hematology

Lymphatic Dysfunction, Not Aplasia, Underlies Milroy Disease

Russell H. Mellor et al.

MICROCIRCULATION (2010)

Article Medicine, Research & Experimental

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

Carrie J. Shawber et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Immunology

Functionally specialized junctions between endothelial cells of lymphatic vessels

Peter Baluk et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Multidisciplinary Sciences

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Mats Hellstroem et al.

NATURE (2007)

Article Multidisciplinary Sciences

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

NW Gale et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Notch signaling controls multiple steps of pancreatic differentiation

LC Murtaugh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

A model for gene therapy of human hereditary lymphedema

MJ Karkkainen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Genetics & Heredity

Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase

A Irrthum et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2000)

Article Genetics & Heredity

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

MJ Karkkainen et al.

NATURE GENETICS (2000)