☆ 4.8 Article

Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+T cell immunity

CELL REPORTS (2023)

Related references

Note: Only part of the references are listed.

Letter Medicine, General & Internal

Antibody Response to Omicron BA.4-BA.5 Bivalent Booster

Qian Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity

Daichao Wu et al.

Summary: T cells play a key role in combating SARS-CoV-2 and forming long-term memory responses. Concerns have been raised about the efficacy of vaccines and the risk of reinfection due to the emergence of SARS-CoV-2 variants that can evade T cell immunity. Mutations in certain T cell epitopes can lead to viral escape by hindering recognition by most T cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

Add to Collection

Article Biochemical Research Methods

The CCP4 suite: integrative software for macromolecular crystallography

Jon Agirre et al.

Summary: The Collaborative Computational Project No. 4 (CCP4) is an international collective led by the UK, dedicated to the development, testing, distribution, and promotion of software for macromolecular crystallography. The CCP4 suite is a multiplatform collection of programs, unified by familiar execution routines, common libraries, and graphical interfaces. This article serves as a general literature citation for the use of the CCP4 software suite, providing an overview of its recent changes, new features, and future developments, while also highlighting the individual programs within the suite and providing up-to-date references for crystallographers worldwide.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2023)

Add to Collection

Article Multidisciplinary Sciences

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Delphine Planas et al.

Summary: The Omicron variant of SARS-CoV-2, identified in November 2021, has spread rapidly worldwide and shows resistance to most therapeutic monoclonal antibodies and vaccine-elicited antibodies. However, it can be neutralized by antibodies generated by a booster vaccine dose.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

Yang Liu et al.

Summary: The B.1.1.7 variant (Alpha) of SARS-CoV-2 emerged in the UK in the summer of 2020, with 19 mutations including N501Y which is a major determinant of increased transmission. The N501Y substitution increased viral transmission by enhancing the spike protein's affinity for cellular receptors, making it an adaptive spike mutation of concern.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

Raquel Viana et al.

Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Leo Swadling et al.

Summary: Research suggests that some individuals can clear potential SARS-CoV-2 infection after exposure, with T cells playing a role in the process. Studying healthcare workers who tested negative for antibodies revealed that they had stronger and more diverse memory T cells, with a focus on RTC.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex

Dhiraj Mannar et al.

Summary: The newly reported Omicron variant shows new salt bridges and hydrogen bonds formed by mutated residues in the receptor binding domain, compensating for reduced ACE2 binding affinity. It also exhibits increased antibody evasion, which likely contributes to its rapid spread.

SCIENCE (2022)

Add to Collection

Article Multidisciplinary Sciences

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

Daichao Wu et al.

Summary: This study reveals the structural information of SARS-CoV-2-specific T-cell receptors (TCRs) bound to their peptide-MHC targets and explains the mechanisms behind their selection of specific germline genes and recognition of different variants. This has important implications for designing vaccines to elicit pan-coronavirus immunity.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients

Corine H. GeurtsvanKessel et al.

Summary: This study demonstrates that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, despite low levels of neutralizing antibodies. Booster vaccinations can partially restore cross-neutralization of the Omicron variant.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escape

Franz-Josef Obermair et al.

Summary: Understanding peptide presentation by specific MHC alleles is crucial for controlling T cell functions and utilizing them for treatments. The commonly used in silico predictions and mass spectroscopy have limitations in precision, sensitivity, and throughput for MHC class II. In this study, a novel mammalian epitope display (MEDi) platform is introduced to map MHC peptide presentation capacity with high resolution and scalability to all MHC II alleles. Furthermore, the presentability of all SARS-CoV-2 peptides in the context of different HLA class II alleles is comprehensively analyzed, revealing potential immune escape mechanisms through alterations in MHC II presentation landscapes.

SCIENCE ADVANCES (2022)

Add to Collection

Article Immunology

Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition

Emily X. C. Tye et al.

Summary: CD4(+) T cells play a crucial role in protecting against viruses, but the impact of SARS-CoV-2 variants on these cells is not well understood. This study identified specific CD4(+) T cell clones that target various proteins of SARS-CoV-2, but some epitopes mutated in variants of concern (VOCs) showed impaired recognition by these cells. These findings highlight the importance of ongoing genomic surveillance to identify new mutations that may evade CD4(+) T cell immunity.

NATURE IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Human T cells recognize HLA-DP–bound peptides in two orientations

Sebastian Klobuch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope

Garry Dolton et al.

Summary: This study examined the CD8 T cell response against a specific epitope of the Spike glycoprotein of SARS-CoV-2 and found that a specific mutation was not recognized by the majority of HLA A*02(+) convalescent patients and vaccinated individuals. This highlights the potential problem of viral escape at prevalent T cell epitopes restricted by high frequency HLAs and suggests the inclusion of multiple viral proteins in next generation vaccines. Monitoring T cell escape in new SARS-CoV-2 variants is crucial.

CELL (2022)

Add to Collection

Letter Medicine, General & Internal

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

Nicole P. Hachmann et al.

Summary: A small study found that omicron subvariants BA.2.12.1, BA.4, and BA.5 of SARS-CoV-2 were more likely to evade neutralizing antibodies induced by both vaccination and previous infection compared to the prior omicron subvariants BA.1 and BA.2.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Add to Collection

Article Multidisciplinary Sciences

Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity

Martin J. Scurr et al.

Summary: Measurement of SARS-CoV-2-specific T cell responses in whole blood can predict the risk of infection. A low magnitude T cell response is associated with a higher risk of infection, while a high magnitude response significantly reduces the risk.

NATURE COMMUNICATIONS (2022)

Add to Collection

Letter Cell Biology

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

Jun Lan et al.

CELL RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

The coding capacity of SARS-CoV-2

Yaara Finkel et al.

Summary: A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

NATURE (2021)

Add to Collection

Article Immunology

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Annika Nelde et al.

Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.

NATURE IMMUNOLOGY (2021)

Add to Collection

Article Infectious Diseases

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

Kathy Leung et al.

Summary: Two new lineages of SARS-CoV-2 with the N501Y mutation in the receptor-binding domain of the spike protein have spread rapidly in the United Kingdom. The 501Y lineage without amino acid deletion Delta 69/Delta 70 was estimated to be 10% more transmissible than the 501N lineage, while the 501Y lineage with amino acid deletion Delta 69/Delta 70 was estimated to be 75% more transmissible than the 501N lineage.

EUROSURVEILLANCE (2021)

Add to Collection

Article Medicine, General & Internal

Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19

Kathryn E. Stephenson et al.

Summary: The study evaluated the immunogenicity of the Ad26.COV2.S vaccine in human participants, showing rapid induction of spike-specific humoral and cellular immune responses. Various antibody subclasses, Fc receptor binding properties, and antiviral functions were induced, along with CD4+ and CD8+ T-cell responses.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Add to Collection

Article Immunology

S-Variant SARS-CoV-2 Lineage B1.1.7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction

Michael Kidd et al.

Summary: Analysis of recent test data shows that samples containing the SARS-CoV-2 variant B1.1.7 with mutation Delta 69/70 exhibit S gene target failure (SGTF) in ThermoFisher TaqPath RT-qPCR. Samples with SGTF profile are more likely to have higher viral loads, indicating higher infectivity and rapid spread of this variant.

JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Immunology

Assessment of SARS-CoV-2 specific CD4(+) and CD8 (+) T cell responses using MHC class I and II tetramers

Yuri Poluektov et al.

Summary: The study focuses on evaluating the binding affinities of SARS-CoV-2 peptides to different MHC alleles using the QuickSwitchTM platform, identifying multiple MHC binders with high promiscuity. These results provide important data for further research on the SARS-CoV-2 virus and its antigenic epitopes.

VACCINE (2021)

Add to Collection

Article Virology

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

Juan Zhao et al.

Summary: Research shows that COVID-19-recovered individuals exhibit specific T cell responses, potentially offering protection against reinfection for some exposed individuals and inducing protective immunity in unexposed individuals upon vaccination. There is a need for a multi-epitope strategy in COVID-19 vaccine design due to the low immunogenicity of SARS-CoV-2 S and N peptides at inducing robust T cell responses.

VIRUS RESEARCH (2021)

Add to Collection

Correction Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (vol 184, pg 2372, 2021)

Wilfredo F. Garcia-Beltran et al.

CELL (2021)

Add to Collection

Article Immunology

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

Laura Bergamaschi et al.

Summary: The kinetics of immune changes in COVID-19 across different severity groups show that early bystander CD8(+) T cell immune response is prominent in asymptomatic or mild diseases, while severe cases have persistent cellular abnormalities and immune defects, which may increase clinical risks.

IMMUNITY (2021)

Add to Collection

Article Immunology

Genome-Wide B Cell, CD4+, and CD8+ T Cell Epitopes That Are Highly Conserved between Human and Animal Coronaviruses, Identified from SARS-CoV-2 as Targets for Preemptive Pan-Coronavirus Vaccines

Swayam Prakash et al.

Summary: The study identified several conserved human B cell and T cell epitopes across different coronaviruses, suggesting potential for developing a pan-coronavirus vaccine; these epitopes triggered immune responses in both COVID-19 patients and individuals never exposed to SARS-CoV-2, as well as in double-transgenic mice; paving the way for a preemptive multiepitope pancoronavirus vaccine to protect against past, current, and future outbreaks.

JOURNAL OF IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Jun Siong Low et al.

Summary: The study demonstrates a robust CD4(+) T cell response to SARS-CoV-2 spike and nucleoprotein in COVID-19-recovered individuals, with a highly immunogenic receptor-binding domain (RBD). Through characterizing T cell clones, it was found that a region containing nested HLA-DR and HLA-DP-restricted epitopes is immunodominant. Cross-reactive T cells targeting multiple S protein sites were identified, which can guide vaccination strategies against emerging SARS-CoV-2 variants.

SCIENCE (2021)

Add to Collection

Article Biochemical Research Methods

Computational epitope map of SARS-CoV-2 spike protein

Mateusz Sikora et al.

Summary: The spike protein of the SARS-CoV-2 virus plays a crucial role in infection and is the primary target for antibodies. Through molecular dynamics simulations and bioinformatics analyses, accessible epitopes have been identified for potential vaccine development. The extensive and flexible glycan coat covering the spike protein presents challenges in antibody binding but also reveals promising epitope candidates for structure-based vaccine design.

PLOS COMPUTATIONAL BIOLOGY (2021)

Add to Collection

Review Microbiology

SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

Alba Grifoni et al.

Summary: This review summarizes recent studies on SARS-CoV-2 T cell epitopes, highlighting the significant correlation between epitope number and antigen size. It also presents an analysis of 1,400 different reported SARS-CoV-2 epitopes and identifies discrete immunodominant regions of the virus and more prevalently recognized epitopes.

CELL HOST & MICROBE (2021)

Add to Collection

Article Immunology

Human CD4+ T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential

Johan Verhagen et al.

Summary: Since December 2019, the rapid spread of COVID-19 has prompted a global effort to develop vaccines and treatments. T cell therapy may enhance the efficacy of current treatments by targeting specific antigens of the virus. Identifying T cells with potentially protective responses against key SARS-CoV-2 antigens is a crucial step towards TCR-transgenic CD4(+) T cell therapy for COVID-19.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

Priyanka Chaurasia et al.

Summary: CD8(+) T cells are crucial in immunity against SARS-CoV-2 infection, with the HLA-A2S(269-277) epitope being the most immunodominant. Studies show that TRAV12(+) T cell receptors are sensitive to sequence variation within the S269-277 peptide. However, the TRAV12(+) T cell repertoire demonstrates poor cross-reactivity with analogous epitopes from SARS-CoV-2 variants and related coronaviruses.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Tyler N. Starr et al.

Summary: An ideal therapeutic anti-SARS-CoV-2 antibody should have resistance to viral escape, activity against diverse sarbecoviruses, and provide high protection through viral neutralization and effector functions. Studies have found a trade-off between in vitro neutralization potency and breadth of sarbecovirus binding in SARS-CoV-2 antibodies targeting the RBD, but identified some antibodies with exceptional sarbecovirus breadth and resistance to SARS-CoV-2 escape.

NATURE (2021)

Add to Collection

Article Multidisciplinary Sciences

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans

Ugur Sahin et al.

Summary: The BNT162b2 vaccine shows 95% efficacy in preventing COVID-19 by boosting neutralizing antibody titres and activating specific T cell responses. The vaccine-induced immune response is broad and stable, lasting for a prolonged period, providing good coverage against various SARS-CoV-2 variants.

NATURE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The landscape of antibody binding in SARS-CoV-2 infection

Anna S. Heffron et al.

Summary: Research shows that SARS-CoV-2 infection triggers robust antibody responses throughout the proteome, with M protein exhibiting excellent diagnostic accuracy. Antibodies also bind to homologous peptide sequences in other known human coronaviruses, and illness severity correlates with increased reactivity to specific epitopes.

PLOS BIOLOGY (2021)

Add to Collection

Article Microbiology

Broadly directed SARS-CoV-2-specific CD4+T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

Janna Heide et al.

Summary: The study aimed to explore the CD4+ T cell response to SARS-CoV-2 and found a universally broad T cell response in patients, identifying multiple specific peptides. These findings are important for understanding the immunopathogenesis of SARS-CoV-2 infection and vaccine design.

PLOS PATHOGENS (2021)

Add to Collection

Article Medicine, General & Internal

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

Lu Lu et al.

Summary: The study demonstrates that the N501Y mutation has a significant impact on neutralizing activity of COVID-19 convalescent sera and anti-RBD IgG assays. Patients infected with N501Y variants may exhibit reduced antibody binding and lower positivity rates in IgG assays.

EBIOMEDICINE (2021)

Add to Collection

Letter Immunology

Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

Daniele Focosi et al.

Summary: This report demonstrates a novel mutation, Q493R, of the SARS-CoV-2 spike protein that confers resistance to both bamlanivimab and etesivimab, isolated from a patient who had received treatment with these drugs.

EMERGING INFECTIOUS DISEASES (2021)

Add to Collection

Article Cell Biology

Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells

Kristen W. Cohen et al.

Summary: The study reveals that COVID-19 patients have durable broad-based immune responses, including the continuous generation of antibodies, memory B cells, and polyfunctional T cells, which help to rapidly generate antibody responses against virus re-exposure or vaccination.

CELL REPORTS MEDICINE (2021)

Add to Collection

Article Cell Biology

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

Tyler N. Starr et al.

Summary: The study mapped mutations to the SARS-CoV-2 spike receptor-binding domain that escape binding by certain monoclonal antibodies. These mutations are concentrated in specific lineages of SARS-CoV-2. The authors suggest diversifying the epitopes targeted by antibodies and antibody cocktails to make them more resilient to SARS-CoV-2 antigenic evolution.

CELL REPORTS MEDICINE (2021)

Add to Collection

Article Cell Biology

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

Alison Tarke et al.

Summary: By studying T cell responses in 99 convalescent COVID-19 cases, we identified various HLA-restricted epitopes derived from SARS-CoV-2 and observed distinct patterns of immunodominance. The epitopes were combined into megapools to facilitate the identification and quantification of virus-specific CD4(+) and CD8(+) T cells.

CELL REPORTS MEDICINE (2021)

Add to Collection

Article Biochemical Research Methods

SciPy 1.0: fundamental algorithms for scientific computing in Python

Pauli Virtanen et al.

NATURE METHODS (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Add to Collection

Article Microbiology

A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

Alba Grifoni et al.

CELL HOST & MICROBE (2020)

Add to Collection

Review Immunology

Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions

Sinu Paul et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Genetics & Heredity

Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2

Kazuma Kiyotani et al.

JOURNAL OF HUMAN GENETICS (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data

Birkir Reynisson et al.

NUCLEIC ACIDS RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Tyler N. Starr et al.

CELL (2020)

Add to Collection

Letter Virology

The Nucleocapsid Protein of SARS-CoV-2: a Target for Vaccine Development

Noton K. Dutta et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Pedro M. Folegatti et al.

LANCET (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Carolyn Rydyznski Moderbacher et al.

CELL (2020)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

Nina Le Bert et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Davide F. Robbiani et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Distinct conformational states of SARS-CoV-2 spike protein

Yongfei Cai et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

Jose Mateus et al.

SCIENCE (2020)

Add to Collection

Article Cell Biology

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Alexander Greenshields-Watson et al.

CELL REPORTS (2020)

Add to Collection

Article Immunology

Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Yanchun Peng et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

E. J. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients

Nisreen M. A. Okba et al.

EMERGING INFECTIOUS DISEASES (2020)

Add to Collection

Article Immunology

Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccines

Lucia Grenga et al.

EMERGING MICROBES & INFECTIONS (2020)

Add to Collection

Article Biochemical Research Methods

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Dorothee Liebschner et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

Bruce J. MacLachlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

MolProbity: More and better reference data for improved all-atom structure validation

Christopher J. Williams et al.

PROTEIN SCIENCE (2018)

Add to Collection

Article Biochemical Research Methods

Nextstrain: real-time tracking of pathogen evolution

James Hadfield et al.

BIOINFORMATICS (2018)

Add to Collection

Article Biochemical Research Methods

DIALS: implementation and evaluation of a new integration package

Graeme Winter et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2018)

Add to Collection

Article Immunology

CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers

Moran Galperin et al.

SCIENCE IMMUNOLOGY (2018)

Add to Collection

Article Immunology

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

Jennifer G. Abelin et al.

IMMUNITY (2017)

Add to Collection

Article Immunology

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope

David K. Cole et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Data, disease and diplomacy: GISAID's innovative contribution to global health

Stefan Elbe et al.

GLOBAL CHALLENGES (2017)

Add to Collection

Article Biochemical Research Methods

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

Sarah M. Theaker et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2016)

Add to Collection

Review Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

Jamie Rossjohn et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Add to Collection

Article Biochemical Research Methods

Decision making in xia2

Graeme Winter et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)

Add to Collection

Article Multidisciplinary Sciences

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection

Akihisa Shimizu et al.

SCIENTIFIC REPORTS (2013)

Add to Collection

Review Immunology

Re-directing CD4(+) T cell responses with the flanking residues of MHC class II-bound peptides: the core is not enough

Christopher J. Holland et al.

FRONTIERS IN IMMUNOLOGY (2013)

Add to Collection

Article Biochemical Research Methods

TCR/pMHC Optimized Protein crystallization Screen

Anna M. Bulek et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2012)

Add to Collection

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Add to Collection

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Add to Collection

Article Multidisciplinary Sciences

Bidirectional binding of invariant chain peptides to an MHC class II molecule

Sebastian Guenther et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection

Article Biochemical Research Methods

Solving structures of protein complexes by molecular replacement with Phaser

Airlie J. McCoy

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2007)

Add to Collection

Article Biochemical Research Methods

Protein production by auto-induction in high-density shaking cultures

FW Studier

PROTEIN EXPRESSION AND PURIFICATION (2005)

Add to Collection

Article Immunology

Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets

JD Lippolis et al.

JOURNAL OF IMMUNOLOGY (2002)

Add to Collection

Article Immunology

Structure of a complex of the human α/β T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA0101 and DRB10401):: Insight into TCR cross-restriction and alloreactivity

J Hennecke et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

Add to Collection

Article Biochemistry & Molecular Biology

Structure of a covalently stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

J Hennecke et al.

EMBO JOURNAL (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.