Journal
NANO RESEARCH
Volume 9, Issue 6, Pages 1630-1638Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1057-2
Keywords
F-19 magnetic resonance imaging; photothermal therapy
Categories
Funding
- National Natural Science Foundation of China [21475007, 21275015, 21505003]
- Fundamental Research Funds for the Central Universities [YS1406, buctrc201507, buctrc201608]
- Innovation and Promotion Project of BUCT
- Public Hatching Platform for Recruited Talents of BUCT
- BUCT Fund for Disciplines Construction and Development [XK1526]
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Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (similar to 5.0 x 10(7) fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized 3,5-bis(trifluoromethyl)benzaldehyde, F-19(OAm)) exhibited a single intense 19F magnetic resonance (MR) signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong F-19 MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous F-19 MR imaging and photothermal therapy.
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