Journal
NANO RESEARCH
Volume 9, Issue 8, Pages 2411-2423Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1127-5
Keywords
amyloid disease; platinum; graphitic carbon nitride nanosheet; photooxygenation; amyloid beta-peptide (A beta) inhibitors
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Funding
- National Basic Research Program of China [2012CB720602, 2011CB936004]
- National Natural Science Foundation of China [21210002, 21431007, 21533008]
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Amyloid beta-peptide (A beta) aggregation is a critical step in the pathogenesis of Alzheimer's disease (AD). Inhibition of A beta production, dissolution of existing aggregates and clearance of A beta represent valid therapeutic strategies against AD. Herein, a novel platinum(II)-coordinated graphitic carbon nitride (g-C3N4) nanosheet (g-C3N4@Pt) has been designed to covalently bind to A beta and modulate the peptide's aggregation and toxicity. Furthermore, g-C3N4@Pt nanosheets possess high photocatalytic activity and can oxygenate A beta upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of A beta. Due to its ability to cross the blood-brain barrier (BBB) and its good biocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of A beta aggregation. This study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of AD.
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