Journal
NANO RESEARCH
Volume 9, Issue 9, Pages 2652-2661Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-016-1152-4
Keywords
magnetic nanorods; drug delivery; enhanced thrombolysis; tissue plasminogen activator; iron oxide
Categories
Funding
- National Science Foundation [ECCS-1303134]
- National Institutes of Health [R21 NS084148-01A1]
- National Science Foundation of Beijing [7161014]
- Key Science and Technology Project of Zhejiang Provincial Health Department [WKJ2013-2-022]
- National Natural Science Foundation of China [81371396]
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1303134] Funding Source: National Science Foundation
Ask authors/readers for more resources
Systemic thrombolysis with intravenous tissue plasminogen activator (tPA) remains the only proven treatment that is effective in improving the clinical outcome of patients with acute ischemic stroke. However, thrombolytic therapy has some major limitations such as hemorrhage, neurotoxicity, and the short time window for the treatment. In this study, we designed iron oxide (Fe3O4) nanorods loaded with 6% tPA, which could be released within similar to 30 min. The Fe3O4 nanorods could be targeted to blood clots under magnetic guidance. In addition, the release of tPA could be significantly increased using an external rotating magnetic field, which subsequently resulted in a great improvement in the thrombolytic efficiency. Systematic and quantitative studies revealed the fundamental physical processes involved in the enhanced thrombolysis, while the in vitro thrombolysis assay showed that the proposed strategy could improve thrombolysis and recanalization rates and reduce the risk of tPA-mediated hemorrhage in vivo. Such a strategy will be very useful for the treatment of ischemic stroke and other deadly thrombotic diseases such as myocardial infarction and pulmonary embolism in clinical settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available