Journal
NANO LETTERS
Volume 16, Issue 3, Pages 1695-1703Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b04611
Keywords
Nanothermometry; rare earth nanoparticles; second biological window; subcutaneous thermal sensing
Categories
Funding
- Spanish Ministerio de Educacion y Ciencia [MAT2013-47395-C4-1-R]
- EU Framework Programme by Brazilian Agencies: FINEP (Financiadora de Estudos e Projetos) [COST-CM1403, INFRAPESQ-11, INFRAPESQ-12]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) Grants INCT NANO(BIO)SIMES [483238/2013-9]
- CAPES (Coordenadoria de Aperfeicoamento de Pessoal de Ensino Superior) by means of Project PVE [A077/2013]
- PhD scholarship from CNPq
- PVE project by means of a PhD sandwich program developed at Universidad Autonoma de Madrid, Spain [A077/2013]
- PVE (Pesquisador Visitante Especial) [A077/2013]
- Post Doctoral Fellowship grant PDE/CAPES at the Universidad Autonoma de Madrid-Spain [2108-14-3]
- Universidad Autonoma de Madrid through an FPI grant
- project CICECO- Aveiro Institute of Materials [FCT UID/CTM/50011/2013]
- national funds through FCT/MEC
- FEDER under Partnership Agreement [PT2020]
- Fundacao para a Ciencia e Tecnologia (Portugal) [SFRH/BPD/89003/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/89003/2012] Funding Source: FCT
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The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd3+ - and Yb3+-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level.
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