Journal
NANO LETTERS
Volume 16, Issue 10, Pages 6257-6264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b02547
Keywords
Au-TiO2 nanocomposite; prolonged circulation; ultrasound; ROS; enhanced sonodynamic therapy
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Funding
- National R&D Program for Cancer Control of MHW [1420040]
- Global Research Laboratory Program [NRF-2013K1A1A2A02076442]
- Basic Science Research Programs of NRF [20100027955, 2015R1A2A2A05001390]
- National Research Foundation of Korea [2014M3A9B8023471, 2015R1A2A2A05001390] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photo dynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nano composites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasoUnd, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for Cancer therapy.
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