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Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology

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Precise Regulation of Enzyme-Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy

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Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

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Photothermal effect enhancing graphene quantum dots/semiconducting polymer/nanozyme-mediated cancer catalytic therapy

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Noble Metal Nanomaterials for NIR-Triggered Photothermal Therapy in Cancer

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Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation

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Chemical design of nanozymes for biomedical applications

Min Wei et al.

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In vivo guiding inorganic nanozymes for biosensing and therapeutic potential in cancer, inflammation and microbial infections

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Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation

Deblin Jana et al.

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ACS NANO (2021)

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Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Xuantong Zhou et al.

Summary: Radioresistance poses a significant challenge in clinical treatments, attributed to factors such as hypoxia in the tumor microenvironment, antioxidant systems in cancer cells, and upregulation of DNA repair proteins. A novel strategy involving GDY-CeO2 nanocomposites and miR181a shows promise in overcoming radioresistance and enhancing therapeutic efficacy in ESCC patients by mitigating hypoxia, promoting DNA damage, and facilitating personalized treatment.

ADVANCED MATERIALS (2021)

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Single-Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy

Mengyu Chang et al.

Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications

Rachel Shi et al.

Summary: Hypoxia, a common feature of solid tumors, poses a challenge to the efficacy of conventional cancer treatments. The adaptive changes in cells under hypoxic conditions lead to survival, metastasis, and malignant phenotypes of tumors.

CELLS (2021)

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Article Nanoscience & Nanotechnology

Immobilizing Enzymes on Noble Metal Hydrogel Nanozymes with Synergistically Enhanced Peroxidase Activity for Ultrasensitive Immunoassays by Cascade Signal Amplification

Jiajia Huang et al.

Summary: Enzyme immobilization is crucial for addressing the fragility of enzymes, but it may impact their bioactivity and catalytic efficiency. PdCu hydrogel nanozymes were used to immobilize horseradish peroxidase, resulting in improved stability and catalytic activity for biosensing of carcinoembryonic antigen. This approach showed promising potential for clinical diagnosis with significantly enhanced detection sensitivity.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Robust O2 Supplementation from a Trimetallic Nanozyme-Based Self-Sufficient Complementary System Synergistically Enhances the Starvation/Photothermal Therapy against Hypoxic Tumors

Cheng-Yun Wu et al.

Summary: This study presents a self-sufficient hybrid enzyme-based system that synergistically alleviates tumor hypoxia and induces an anti-cancer effect when combined with irradiation of light from a near-infrared laser. The system consists of Pt-decorated hollow Ag-Au trimetallic nanocages and glucose oxidase, which can continuously supply O-2 and consume glucose to enhance the therapeutic efficacy of combined starvation and photothermal therapy in hypoxic tumors.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Albumin-Templated Bi2Se3-MnO2 Nanocomposites with Promoted Catalase-Like Activity for Enhanced Radiotherapy of Cancer

Yuzhu Yao et al.

Summary: In this study, Bi2Se3-MnO2@BSA nanocomposites were successfully prepared via biomineralization, with Bi2Se3 and MnO2 acting as radiosensitizers and oxygen enhancers to improve tumor radiosensitivity. BSA templating provided high biocompatibility and stability to the nanocomposites, enhancing the efficacy of radiotherapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

A Bionanozyme with Ultrahigh Activity Enables Spatiotemporally Controlled Reactive Oxygen Species Generation for Cancer Therapy

Zhen Xu et al.

Summary: Nanozymes have great potential in nanomedicine, but their clinical translation is limited by biotoxicity. A new type of bionanozyme with ultrahigh and light-controlled catalytic activity has been developed through self-assembly and in situ polymerization, showing potential for tumor-specific therapy with minimal biotoxicity.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Smart Nanozyme Platform with Activity-Correlated Ratiometric Molecular Imaging for Predicting Therapeutic Effects

Lili Teng et al.

Summary: A novel nanozyme with oxidase-like activity was developed for acid-induced cancer therapy, utilizing ratiometric near-infrared fluorescence-photoacoustic molecular imaging to report its catalytic activity. The nanozyme showed excellent anticancer efficacy in the tumor microenvironment, and the ratiometric signals provided a new approach for predicting its efficacy in living systems.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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X-ray-facilitated redox cycling of nanozyme possessing peroxidase-mimicking activity for reactive oxygen species-enhanced cancer therapy

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Summary: The proposed methodology accelerates the enzymatic activity of nanomaterials for tumor therapy by enhancing redox cycling in the presence of X-ray. The nanocomposite under external X-ray irradiation persists in generating ROS, indicating a synergistic effect for cancer treatment.

BIOMATERIALS (2021)

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Dual lock-and-key-controlled ceria nanotubes-based nanozymes for tumor-specific photothermal therapy

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DYES AND PIGMENTS (2021)

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Article Nanoscience & Nanotechnology

Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis

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Summary: Reactive oxygen species (ROS) play important roles in the cell cycle, and disrupting ROS homeostasis in the tumor microenvironment is recognized as an ideal antitumor strategy. The study developed a novel theranostic nanoagent based on PEG@Cu2-xS@Ce6 nanozymes (PCCNs) and demonstrated their effectiveness in generating ROS, inducing photodynamic therapy (PDT) and photothermal therapy (PTT), and depleting glutathione (GSH). The PCCNs showed promising antitumor efficacy in vitro and in vivo by disrupting ROS homeostasis and enhancing therapy under the guidance of photothermal/photoacoustic imaging.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Engineering, Biomedical

Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment

Chongchong Wang et al.

Summary: Utilizing TiO2-modified Pd NS to enhance catalytic activity can lead to the creation of nanomotors with synergistic effects of photodynamic therapy and photothermal therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

Hang Wu et al.

Summary: This study presents a novel nanoenzyme-based theranostic nanoplatform for combined photothermal therapy (PTT) and photodynamic therapy (PDT), showing enhanced photothermal conversion efficiency under NIR irradiation and the ability to produce reactive oxygen species under 660 nm NIR laser irradiation. The findings suggest the potential of theranostic nanoenzymes for translational medicine.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Biodegradable and Peroxidase-Mimetic Boron Oxynitride Nanozyme for Breast Cancer Therapy

Lula Zeng et al.

Summary: This study introduces a peroxidase-like artificial enzyme based on boron oxynitride for efficient breast cancer therapies, showing a high potency in inhibiting tumor growth by inducing apoptosis of cancer cells. Compared with other nanomaterials, the BON nanozyme demonstrates superior effectiveness in treating breast cancer.

ADVANCED SCIENCE (2021)

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Review Oncology

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Apriliana E. R. Kartikasari et al.

Summary: Chronic inflammation induced by the tumor microenvironment plays a vital role in cancer initiation, progression, and therapy resistance, with cytokines potentially serving as biomarkers. Analyzing circulating cytokines in conjunction with cancer-specific biomarkers could potentially enhance cancer detection, prognosis, and treatment decisions.

FRONTIERS IN ONCOLOGY (2021)

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Review Nanoscience & Nanotechnology

Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy

Foad Rommasi et al.

Summary: The increasing prevalence of cancer is a serious concern for scientists and physicians. Effective cancer treatment remains a major challenge in the health and medicine field, with drug therapies often facing barriers such as adverse effects and lack of specificity and sensitivity.

NANOSCALE RESEARCH LETTERS (2021)

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Review Chemistry, Multidisciplinary

Porous crystalline frameworks for thermocatalytic CO2 reduction: an emerging paradigm

Sunil Mehla et al.

Summary: Heterogeneous catalysts derived from porous, crystalline frameworks for CO2 reduction show high efficiency and superior selectivity. The spatial arrangement of active sites in these frameworks is crucial for their performance. The review discusses thermodynamic considerations, process parameters, and strategies for enhancing stability and promoting CO2 reduction with porous, crystalline frameworks.

ENERGY & ENVIRONMENTAL SCIENCE (2021)

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Article Materials Science, Multidisciplinary

Catalase-like nanosystem for interlocking trimodal cancer therapy with hypoxia relief

Liyao Luo et al.

Summary: The development of Pt@Au-Ce6/Res-Lip nanovesicle overcame the issue of hypoxia in solid tumors affecting the efficacy of PDT. This nanoparticle generated large amounts of oxygen in the tumor microenvironment and combined chemotherapy, photothermal therapy, and PDT to show highly effective anticancer effects.

SCIENCE CHINA-MATERIALS (2021)

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Article Chemistry, Multidisciplinary

GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy

Xiaoyan Zhong et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Virus-Like Fe3O4@Bi2S3 Nanozymes with Resistance-Free Apoptotic Hyperthermia-Augmented Nanozymitic Activity for Enhanced Synergetic Cancer Therapy

Yajie Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Smart Tumor Microenvironment-Responsive Nanotheranostic Agent for Effective Cancer Therapy

Shi-yan Guo et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Specific Unlocking of a Nanozyme-Based Butterfly Effect To Break the Evolutionary Fitness of Chaotic Tumors

Wenyao Zhen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

ROS in cancer therapy: the bright side of the moon

Bruno Perillo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

Xi Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Degradable Holey Palladium Nanosheets with Highly Active 1D Nanoholes for Synergetic Phototherapy of Hypoxic Tumors

Shanshan Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Multidisciplinary Sciences

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Dongdong Wang et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Peroxidase-Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Peixia Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Porous Au@Rh Bimetallic Core-Shell Nanostructure as an H2O2-Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Jinping Wang et al.

ADVANCED MATERIALS (2020)

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Article Biochemical Research Methods

Hyaluronic Acid-Modified Au-Ag Alloy Nanoparticles for Radiation/Nanozyme/Ag+ Multimodal Synergistically Enhanced Cancer Therapy

Yu Chong et al.

BIOCONJUGATE CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

Karol Bukowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Cu2MoS4/Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy

Mengyu Chang et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Zhaohua Miao et al.

NANO LETTERS (2020)

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Article Chemistry, Multidisciplinary

Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Yongxin Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy

Shiyan Fu et al.

BIOMATERIALS (2020)

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Article Biophysics

A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level

Hao-Han Pang et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Multidisciplinary Sciences

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

Hongzhang Deng et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Nanozyme-mediated cascade reaction based on metal-organic framework for synergetic chemo-photodynamic tumor therapy

Shu Sheng et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Materials Science, Multidisciplinary

Targeted self-activating Au-Fe3O4 composite nanocatalyst for enhanced precise hepatocellular carcinoma therapy via dual nanozyme-catalyzed cascade reactions

Xueqin Wang et al.

APPLIED MATERIALS TODAY (2020)

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Article Nanoscience & Nanotechnology

Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation

Xiaoling Li et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

In situ fabrication of MS@MnO2 hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy

Xufeng Zhu et al.

NANOSCALE (2020)

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Article Chemistry, Multidisciplinary

Oxygen-Deficient Bimetallic Oxide FeWOX Nanosheets as Peroxidase-Like Nanozyme for Sensing Cancer via Photoacoustic Imaging

Fei Gong et al.

SMALL (2020)

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Article Multidisciplinary Sciences

Visualization nanozyme based on tumor microenvironment unlocking for intensive combination therapy of breast cancer

Zhiyi Wang et al.

SCIENCE ADVANCES (2020)

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Article Medicine, Research & Experimental

Self-activated in vivo therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes

Wen Liu et al.

THERANOSTICS (2020)

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Review Chemistry, Multidisciplinary

Nanozyme-based catalytic theranostics

Yanan Zhang et al.

RSC ADVANCES (2020)

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Article Materials Science, Biomaterials

Nanoscale dual-enzyme cascade metal-organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

Shuiling Jin et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Nanoscience & Nanotechnology

Nanozymes for Catalytic Cancer Immunotherapy

Jun Ma et al.

ACS APPLIED NANO MATERIALS (2020)

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Article Materials Science, Biomaterials

Ultrasmall theranostic nanozymes to modulate tumor hypoxia for augmenting photodynamic therapy and radiotherapy

Qing Dan et al.

BIOMATERIALS SCIENCE (2020)

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Article Engineering, Biomedical

Porous platinum nanoparticles as a high-Z and oxygen generating nanozyme for enhanced radiotherapy in vivo

Yan Li et al.

BIOMATERIALS (2019)

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Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

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Article Chemistry, Inorganic & Nuclear

Controlled synthesis of core-shell composites with uniform shells of a covalent organic framework

Youjin Yao et al.

INORGANIC CHEMISTRY COMMUNICATIONS (2019)

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Review Chemistry, Physical

Nanozymes with intrinsic peroxidase-like activities

Farnoosh Attar et al.

JOURNAL OF MOLECULAR LIQUIDS (2019)

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Review Medicine, General & Internal

Epithelial ovarian cancer

Stephanie Lheureux et al.

LANCET (2019)

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Article Chemistry, Multidisciplinary

A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy

Zhimei He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Multidisciplinary

Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

Minmin Liang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Review Chemistry, Analytical

Aptamer-based electrochemical cytosensors for tumor cell detection in cancer diagnosis: A review

Duanping Sun et al.

ANALYTICA CHIMICA ACTA (2019)

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Article Chemistry, Analytical

Light-Responsive Metal-Organic Framework as an Oxidase Mimic for Cellular Glutathione Detection

Yufeng Liu et al.

ANALYTICAL CHEMISTRY (2019)

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Review Nanoscience & Nanotechnology

Current trends and challenges in cancer management and therapy using designer nanomaterials

P. N. Navya et al.

NANO CONVERGENCE (2019)

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Article Chemistry, Multidisciplinary

A Tumor-Microenvironment-Activated Nanozyme-Mediated Theranostic Nanoreactor for Imaging-Guided Combined Tumor Therapy

Feng Liu et al.

ADVANCED MATERIALS (2019)

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Article Oncology

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act. In. Sarc): a multicentre, phase 2-3, randomised, controlled trial

Sylvie Bonvalot et al.

LANCET ONCOLOGY (2019)

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Article Chemistry, Multidisciplinary

Nanozymes-Engineered Metal-Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy

Chuang Liu et al.

NANO LETTERS (2019)

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Article Multidisciplinary Sciences

Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study

Ardeshir R. Rastinehad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Chemistry, Multidisciplinary

Enhanced Tumor Synergistic Therapy by Injectable Magnetic Hydrogel Mediated Generation of Hyperthermia and Highly Toxic Reactive Oxygen Species

Haoan Wu et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR-II Light

Mei Wen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

A Nanozyme with Photo-Enhanced Dual Enzyme-Like Activities for Deep Pancreatic Cancer Therapy

Shanshan Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Engineering, Biomedical

Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer

Yidan Wang et al.

BIOMATERIALS (2019)

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Article Multidisciplinary Sciences

A method for structure prediction of metal-ligand interfaces of hybrid nanoparticles

Sami Malola et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Recent Advances in Nanozyme Research

Hui Wang et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

Shanshan Gao et al.

ADVANCED SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma

Bing Jiang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

A Versatile Theranostic Nanoemulsion for Architecture-Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

Yifan Zhang et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Catalase-like metal-organic framework nanoparticles to enhance radiotherapy in hypoxic cancer and prevent cancer recurrence

Yuanyuan Chen et al.

CHEMICAL SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Nanoceria decorated flower-like molybdenum sulphide nanoflakes: an efficient nanozyme for tumour selective ROS generation and photo thermal therapy

Chandran Murugan et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

A cobalt-doped iron oxide nanozyme as a highly active peroxidase for renal tumor catalytic therapy

Yixuan Wang et al.

RSC ADVANCES (2019)

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Article Medicine, Research & Experimental

Carbon-gold hybrid nanoprobes for real-time imaging, photothermal/photodynamic and nanozyme oxidative therapy

Amin Zhang et al.

THERANOSTICS (2019)

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Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Nanoscience & Nanotechnology

Seeded Growth Synthesis of Gold Nanotriangles: Size Control, SAXS Analysis, and SERS Performance

Christian Kuttner et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Tumor Catalytic-Photothermal Therapy with Yolk-Shell Gold@Carbon Nanozymes

Lei Fan et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy

Yan Zhang et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Nanoisozymes: Crystal-Facet-Dependent Enzyme-Mimetic Activity of V2O5 Nanomaterials

Sourav Ghosh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Engineering, Biomedical

Combination cancer treatment through photothermally controlled release of selenous acid from gold nanocages

Haoyan Cheng et al.

BIOMATERIALS (2018)

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Review Biochemistry & Molecular Biology

The emerging role of nanomaterials in immunological sensing-a brief review

Simon R. Corrie et al.

MOLECULAR IMMUNOLOGY (2018)

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Article Medicine, Research & Experimental

Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy

Lingtong Meng et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Biochemical Research Methods

Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes

Bing Jiang et al.

NATURE PROTOCOLS (2018)

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Article Multidisciplinary Sciences

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Kelong Fan et al.

NATURE COMMUNICATIONS (2018)

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Article Materials Science, Biomaterials

Porous nanozymes: the peroxidase-mimetic activity of mesoporous iron oxide for the colorimetric and electrochemical detection of global DNA methylation

Ripon Bhattacharjee et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Materials Science, Biomaterials

Au-PLGA Hybrid Nanoparticles with Catalase-Mimicking and near-Infrared Photothermal Activities for Photoacoustic Imaging-Guided Cancer Therapy

Juqun Xi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Materials Science, Biomaterials

Au-PLGA Hybrid Nanoparticles with Catalase-Mimicking and near-Infrared Photothermal Activities for Photoacoustic Imaging-Guided Cancer Therapy

Juqun Xi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Article Engineering, Biomedical

Iridium nanocrystals encapsulated liposomes as near-infrared light controllable nanozymes for enhanced cancer radiotherapy

Liangzhu Feng et al.

BIOMATERIALS (2018)

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Review Pharmacology & Pharmacy

Prussian blue nanoparticles: Synthesis, surface modification, and application in cancer treatment

Milan Gautam et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Agriculture, Multidisciplinary

Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells

Jhin-Baek Choi et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Mesoporous Encapsulated Chiral Nanogold for Use in Enantioselective Reactions

Ya Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Multidisciplinary Sciences

Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

Yu Chong et al.

NATURE COMMUNICATIONS (2018)

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Article Chemistry, Physical

General synthesis and definitive structural identification of MN4C4 single-atom catalysts with tunable electrocatalytic activities

Huilong Fei et al.

NATURE CATALYSIS (2018)

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Article Chemistry, Multidisciplinary

Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

G. Vinothkumar et al.

NEW JOURNAL OF CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

Karsten Korschelt et al.

NANOSCALE (2017)

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Article Chemistry, Multidisciplinary

MoS2 monolayer catalyst doped with isolated Co atoms for the hydrodeoxygenation reaction

Guoliang Liu et al.

NATURE CHEMISTRY (2017)

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Article Multidisciplinary Sciences

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

Minfeng Huo et al.

NATURE COMMUNICATIONS (2017)

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Article Chemistry, Multidisciplinary

Size-tunable uniform gold octahedra: fast synthesis, characterization, and plasmonic properties

Yonggang Lu et al.

RSC ADVANCES (2017)

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Article Medicine, Research & Experimental

Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy

Dongdong Wang et al.

THERANOSTICS (2017)

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Article Chemistry, Multidisciplinary

A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

Namrata Singh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Article Nanoscience & Nanotechnology

MOF-Mediated Destruction of Cancer Using the Cell's Own Hydrogen Peroxide

Hadi Ranji-Burachaloo et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Biophysics

Colorimetric assay of heparin in plasma based on the inhibition of oxidaselike activity of citrate-capped platinum nanoparticles

Jyun-Guo You et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Article Biophysics

Structural effect of Fe3O4 nanoparticles on peroxidase-like activity for cancer therapy

Shiyan Fu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Biophysics

ATP-mediated intrinsic peroxidase-like activity of Fe3O4-based nanozyme: One step detection of blood glucose at physiological pH

N. V. Srikanth Vallabani et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Chemistry, Multidisciplinary

Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site

Kelong Fan et al.

CHEMICAL COMMUNICATIONS (2017)

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Review Genetics & Heredity

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

Ibtissam Marchiq et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Article Chemistry, Multidisciplinary

Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage

Cuicui Ge et al.

ACS NANO (2016)

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Article Chemistry, Analytical

Efficient Enhancement of Electrochemiluminescence from Cadmium Sulfide Quantum Dots by Glucose Oxidase Mimicking Gold Nanoparticles for Highly Sensitive Assay of Methyltransferase Activity

Hong Zhou et al.

ANALYTICAL CHEMISTRY (2016)

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Article Engineering, Biomedical

H2O2-triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics

Changsun Kang et al.

BIOMATERIALS (2016)

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Review Biotechnology & Applied Microbiology

Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

Akhil Patel et al.

BIOTECHNOLOGY ADVANCES (2016)

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Article Materials Science, Multidisciplinary

Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

Ran Mo et al.

MATERIALS TODAY (2016)

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Review Biochemistry & Molecular Biology

Carbon Nanodots as Peroxidase Nanozymes for Biosensing

Bhaskar Garg et al.

MOLECULES (2016)

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Article Nanoscience & Nanotechnology

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

Saeid Zanganeh et al.

NATURE NANOTECHNOLOGY (2016)

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Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

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Article Materials Science, Biomaterials

Novel hierarchical NiO nanoflowers exhibiting intrinsic superoxide dismutase-like activity

Jianshuai Mu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Nanoscience & Nanotechnology

Cancer Cell Detection and Therapeutics Using Peroxidase-Active Nanohybrid of Gold Nanoparticle-Loaded Mesoporous Silica-Coated Graphene

Swarup Kumar Maji et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

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Article Chemistry, Multidisciplinary

Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic

Xiaohu Xia et al.

ACS NANO (2015)

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Article Engineering, Biomedical

Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium

Junnan Li et al.

BIOMATERIALS (2015)

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Article Engineering, Biomedical

Highly sensitive and robust peroxidase-like activity of porous nanorods of ceria and their application for breast cancer detection

Zhimin Tian et al.

BIOMATERIALS (2015)

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Article Multidisciplinary Sciences

Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters

Errol L. G. Samuel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Chemistry, Multidisciplinary

Dendritic Silica Particles with Center-Radial Pore Channels: Promising Platforms for Catalysis and Biomedical Applications

Xin Du et al.

SMALL (2015)

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Article Nanoscience & Nanotechnology

Co3O4 Nanoparticles with Multi-Enzyme Activities and Their Application in Immunohistochemical Assay

Jinlai Dong et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Article Chemistry, Multidisciplinary

Multifunctional Albumin-MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

Preethy Prasad et al.

ACS NANO (2014)

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Article Chemistry, Analytical

Label-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles

Zhifei Wang et al.

ANALYST (2014)

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Article Biochemical Research Methods

Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance

Guanglei Fu et al.

BIOCONJUGATE CHEMISTRY (2014)

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Review Radiology, Nuclear Medicine & Medical Imaging

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

L. Sancey et al.

BRITISH JOURNAL OF RADIOLOGY (2014)

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Review Chemistry, Multidisciplinary

Superoxide Dismutases and Superoxide Reductases

Yuewei Sheng et al.

CHEMICAL REVIEWS (2014)

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Review Pharmacology & Pharmacy

The effects of engineered nanoparticles on pulmonary immune homeostasis

Rohimah Mohamud et al.

DRUG METABOLISM REVIEWS (2014)

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Article Chemistry, Physical

Characterization of glucose oxidation by gold nanoparticles using nanoceria

Nathan J. Lang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2014)

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Article Chemistry, Multidisciplinary

Enhanced Fluorescence of Gold Nanoclusters Composed of HAuCl4 and Histidine by Glutathione: Glutathione Detection and Selective Cancer Cell Imaging

Xiaodong Zhang et al.

SMALL (2014)

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Article Chemistry, Multidisciplinary

V2O5 nanowires as a robust and efficient peroxidase mimic at high temperature in aqueous media

Jianxin Xie et al.

RSC ADVANCES (2014)

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Article Engineering, Biomedical

Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network

Jin Di et al.

ADVANCED HEALTHCARE MATERIALS (2014)

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Review Biochemistry & Molecular Biology

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Yang Feng et al.

BIOMEDICINES (2014)

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Article Nanoscience & Nanotechnology

Peroxidase-Like Activity of Fe3O4@Carbon Nanoparticles Enhances Ascorbic Acid-Induced Oxidative Stress and Selective Damage to PC-3 Prostate Cancer Cells

Qiao An et al.

ACS APPLIED MATERIALS & INTERFACES (2013)

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Article Engineering, Biomedical

Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

Weiwei He et al.

BIOMATERIALS (2013)

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Article Oncology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Veronica Estrella et al.

CANCER RESEARCH (2013)

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Article Chemistry, Physical

Size-Dependent Photothermal Conversion Efficiencies of Plasmonically Heated Gold Nanoparticles

Ke Jiang et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2013)

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Article Chemistry, Multidisciplinary

A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging

Fang Yang et al.

ADVANCED MATERIALS (2012)

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Review Chemistry, Multidisciplinary

Functional Gold Nanorods: Synthesis, Self-Assembly, and Sensing Applications

Leonid Vigderman et al.

ADVANCED MATERIALS (2012)

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Review Chemistry, Multidisciplinary

Cancer detection using nanoparticle-based sensors

Maelle Perfezou et al.

CHEMICAL SOCIETY REVIEWS (2012)

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Review Biochemical Research Methods

Microfluidic approaches for cancer cell detection, characterization, and separation

Jian Chen et al.

LAB ON A CHIP (2012)

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Article Nanoscience & Nanotechnology

Magnetoferritin nanoparticles for targeting and visualizing tumour tissues

Kelong Fan et al.

NATURE NANOTECHNOLOGY (2012)

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Article Cell Biology

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis The seed and soil also needs fertilizer

Michael P. Lisanti et al.

CELL CYCLE (2011)

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Article Chemistry, Multidisciplinary

Structural Effects of Fe3O4 Nanocrystals on Peroxidase-Like Activity

Shanhu Liu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

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Article Oncology

Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme

Klaus Maier-Hauff et al.

JOURNAL OF NEURO-ONCOLOGY (2011)

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Review Oncology

Targeting hypoxia in cancer therapy

William R. Wilson et al.

NATURE REVIEWS CANCER (2011)

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Review Neurosciences

Detection of cancer cells in the cerebrospinal fluid: current methods and future directions

Cody L. Weston et al.

FLUIDS AND BARRIERS OF THE CNS (2011)

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Review Medicine, Research & Experimental

Molecular Diagnosis and Therapy of Kidney Cancer

W. Marston Linehan et al.

ANNUAL REVIEW OF MEDICINE (2010)

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Article Chemistry, Multidisciplinary

Facile Synthesis of Ag Nanocubes of 30 to 70 nm in Edge Length with CF3COOAg as a Precursor

Qiang Zhang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2010)

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Article Oncology

Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine

Steven K. Libutti et al.

CLINICAL CANCER RESEARCH (2010)

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Editorial Material Chemistry, Multidisciplinary

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

Alaaldin M. Alkilany et al.

JOURNAL OF NANOPARTICLE RESEARCH (2010)

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Review Multidisciplinary Sciences

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Arnold J. Levine et al.

SCIENCE (2010)

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Article Oncology

Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells

Ahmed Abdal Dayem et al.

Cancers (2010)

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Review Biotechnology & Applied Microbiology

Glucose oxidase - An overview

Sandip B. Bankar et al.

BIOTECHNOLOGY ADVANCES (2009)

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Review Medicine, Research & Experimental

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

Yuri Kim et al.

CURRENT MOLECULAR MEDICINE (2009)

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Article Oncology

Clinical applications of magnetic nanoparticles for hyperthermia

Burghard Thiesen et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2008)

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Review Biochemistry & Molecular Biology

The tumor microenvironment and its role in promoting tumor growth

T. L. Whiteside

ONCOGENE (2008)

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Article Nanoscience & Nanotechnology

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

Lizeng Gao et al.

NATURE NANOTECHNOLOGY (2007)

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Article Physics, Multidisciplinary

Evidence of subsurface oxygen vacancy ordering on reduced CeO2(111)

Stefan Torbruegge et al.

PHYSICAL REVIEW LETTERS (2007)

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Review Oncology

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment

Benjamin J. Moeller et al.

CANCER AND METASTASIS REVIEWS (2007)

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Article Oncology

Molecular characterization of the tumor microenvironment in breast cancer

M Allinen et al.

CANCER CELL (2004)

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Article Multidisciplinary Sciences

Stromal fibroblasts in cancer initiation and progression

NA Bhowmick et al.

NATURE (2004)

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Review Oncology

Hypoxia - A key regulatory factor in tumour growth

AL Harris

NATURE REVIEWS CANCER (2002)

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