A Bioresorbable and Conductive Scaffold Integrating Silicon Membranes for Peripheral Nerve Regeneration

Peripheral nerve injury represents one of the most common types of traumatic damage, severely impairing motor and sensory functions, and posttraumatic nerve regeneration remains a major challenge. Electrical cues are critical bioactive factors that promote nerve regrowth, and bioartificial scaffolds incorporating conductive materials to enhance the endogenous electrical field have been demonstrated to be effective. The utilization of fully biodegradable scaffolds can eliminate material residues, and circumvent the need for secondary retrieval procedures. Here, a fully bioresorbable and conductive nerve scaffold integrating N-type silicon (Si) membranes is proposed, which can deliver both structural guidance and electrical cues for the repair of nerve defects. The entire scaffold is fully biodegradable, and the introduction of N-type Si can significantly promote the proliferation and production of neurotrophic factors of Schwann cells and enhance the calcium activity of dorsal root ganglion (DRG) neurons. The conductive scaffolds enable accelerated nerve regeneration and motor functional recovery in rodents with sciatic nerve transection injuries. This work sheds light on the advancement of bioresorbable and electrically active materials to achieve desirable neural interfaces and improved therapeutic outcomes, offering essential strategies for regenerative medicine. Fully bioresorbable and conductive nerve scaffolds integrating silicon membranes are proposed, which can deliver structural guidance and enhance endogenous electrical cues for the repair of nerve defects. The conductive scaffolds enable accelerated nerve regeneration and motor functional recovery in rodents with transected sciatic nerves. This work sheds light on the advancement of bioresorbable and electrically active materials for regenerative medicine.image

Automated summary

A fully bioresorbable and conductive nerve scaffold is proposed in this study, which can provide structural guidance and electrical cues for nerve defect repair, promoting nerve regeneration and motor functional recovery. This work is of great significance for improving therapeutic outcomes in regenerative medicine.