Journal
NANO LETTERS
Volume 16, Issue 9, Pages 5917-5922Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b02828
Keywords
Collagen; microfluidics; microfiber; mechanical properties; biomaterial; axon growth
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Funding
- Deutsche Forschungsgemeinschaft [SCHE 603/14-1]
- ERC [291211]
- European Research Council (ERC) [291211] Funding Source: European Research Council (ERC)
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Collagens arc widely used as biomaterials in drug-delivery and tissue engineering applications due to their biodegradability, biocompatibility and hypoallergenicity. sides gelatin-based materials, collagen microfibers are in the focus of biomedical research. Commonly; man-made fibers are produced by wet-spinning yielding fiber diameters higher than 8 mu m. Here, assembly and continuous,production of single collagen type I microfibers were established using a microfluidic chip. Microfluidics-produced microfibers exhibited :tensile strength and Young's modulus-exceeding that of fibers produced in classical wet-spinning devices and even that of natural tendon and they showed lower diameters. Their structural orientation was examined by polarized Fourier transform infrared spectroscopy (FTIR) showing fibril alignment within the, microfiber. Cell culture tests using the neuronal-cell line NG108-15 showed cell alignment and axon growth along the microfiber axes inaugurating potential applications in, for example, peripheral nerve repair.
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