Journal
NANO LETTERS
Volume 16, Issue 7, Pages 4069-4073Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b00664
Keywords
Polymer; block copolymer; micelle; MRI; gadolinium; nanoparticle
Categories
Funding
- EU [FEDER-35477]
- ANR agency (ANR-DFG) [ANR-11-INTB-1004]
- Region Midi-Pyrenees (Chaire d'excellence Pierre de Fermat) [12012781]
- CNRS
- Agence Nationale de la Recherche (ANR) [ANR-11-INTB-1004] Funding Source: Agence Nationale de la Recherche (ANR)
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Mixing double-hydrophilic block copolymers containing a poly(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies.
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