Neuropsychological Impairments in Patients With Post-traumatic Epilepsy: A Scoping Review

-OBJECTIVES: To date, the research on the prognosis of the neuropsychological function of patients with post-traumatic seizure (PTE) is sparse. This study aimed to systematically map the literature's extent, range, and characteristics regarding PTE and neuropsychological impairments.-METHODS: A systematic literature search was conducted in CINAHL, Cochrane, Embase, Medline, PubMed, Scopus, Web of Science, and Science-Direct databases. The search terms were related to PTE and neuropsychological impairments.-RESULTS: This scoping review included seven studies, two of which examined the impact of PTE on neuropsychological outcomes. Among the three studies that used neuropsychological assessments, attention/concentration, and memory were the most frequently assessed domains. Only one study reported a significant difference between PTE and non-PTE patients. The cognitive rating scale findings in the other four studies were similar, indicating that patients with PTE performed worse than those without PTE.-CONCLUSIONS: The results of this review suggest that patients with PTE may have neuropsychological function impairments. More attention needs to be paid to older patients and those with higher brain injury and seizure severity. Additional investigation is necessary to determine the clinical characteristics of TBI and PTE and elucidate the relations between PTE and specific neuropsychological domains.

Automated summary

The research on the prognosis of neuropsychological function in patients with post-traumatic seizures (PTE) is limited. This study systematically reviewed the literature on PTE and neuropsychological impairments, and found that PTE patients may have impairments in neuropsychological function. More attention should be given to older patients and those with higher brain injury and seizure severity.