Journal
NANO LETTERS
Volume 16, Issue 2, Pages 842-848Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b02428
Keywords
siRNA; mRNA; polymer brush; erythropoietin; nanomaterial
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Funding
- National Cancer Institute Center of Cancer Nanotechnology Excellence at MIT-Harvard [U54-CA151884]
- National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), as a Program of Excellence in Nanotechnology (PEN) Award [HHSN268201000045C]
- Shire
- Alnylam Pharmaceuticals
- NIH [R01-EB000244-27, 5-R01-CA132091-04, R01-DE016516-03]
- National Institute of Biomedical Imaging and Bioengineering [1F32EB017625]
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Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.
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