Journal
NANO LETTERS
Volume 16, Issue 3, Pages 1574-1582Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.5b04237
Keywords
mesenchymal stem cells; nanoghosts; nonviral gene therapy; targeted cancer therapy
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Funding
- Israeli Office of the Chief Scientist (OCS) under the K.A.M.I.N. program [51333, 53774]
- Israel Cancer Association (ICA) [20150094]
- Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology (IIT)
- Satell Family Foundation
- Bert Richardson Foundation by the American Technion Society (ATS)
- Goldy Family Research Fund
- Sharon & Rubin Pikus Fund
- ATS
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Nanoghosts derived from mesenchymal stem cells and retaining their unique surface-associated tumor-targeting capabilities were redesigned as a selective and safe universal nonviral gene-therapy platform. pDNA-loaded nano ghosts efficiently targeted and transfected diverse cancer cells, in vitro and in vivo, in subcutaneous and metastatic orthotopic tumor models, leading to no adverse effects. Nanoghosts loaded with pDNA encoding for a cancer-toxic gene inhibited the growth of metastatic orthotopic lung cancer and subcutaneous prostate cancer models and dramatically prolonged the animals' survival.
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