4.7 Article

Noncanonical functions of Ku may underlie essentiality in human cells

Related references

Note: Only part of the references are listed.
Review Cell Biology

Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello et al.

Summary: The article reviews the impact of telomere shortening and dysfunction on aging and a variety of age-related diseases in humans. Accumulation of senescent cells in aging organisms is believed to contribute to bodily dysfunction. Telomere shortening and damage are known causes of cellular senescence and aging. The authors argue that telomeric dysfunction plays a broad role in human pathologies associated with normal aging.

NATURE CELL BIOLOGY (2022)

Review Cell Biology

V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery

Shaun M. Christie et al.

Summary: V(D)J recombination is a crucial mechanism in the adaptive immune system, generating diverse antigen receptors. This review focuses on the regulatory functions of RAGs, recruitment of RAGs and formation of paired complexes, transition from post-cleavage complex to repair phase, and redundant roles of certain factors in break repair. Understanding these processes is important for avoiding off-target recombination or deficiency-mediated clinical manifestations.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Review Biology

The multiple mechanisms of MCL1 in the regulation of cell fate

Hayley Widden et al.

Summary: This review synthesizes studies on the influence of MCL1 on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control, highlighting its broader role in cellular homeostasis regulation. The authors discuss potential pathways affected by MCL1 inhibitors and suggest the future use of BH3-mimetics for non-cancerous diseases.

COMMUNICATIONS BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The Ku complex: recent advances and emerging roles outside of non-homologous end-joining

Sanna Abbasi et al.

Summary: The Ku complex, discovered in 1981, has been extensively studied for its essential role in non-homologous end-joining (NHEJ), but also implicated in various other cellular processes. Advances in understanding Ku's role in different species and cellular functions have been driven by studies on its structure, expression, conservation, and interactions, as well as its involvement in clinical research.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Multifaceted Roles of Ku70/80

Sayma Zahid et al.

Summary: DNA double-strand breaks are accidental lesions caused by various stresses and genetically programmed events. Most DSBs are repaired in mammalian cells through the classical nonhomologous end-joining pathway, with Ku playing a central role. In addition to its DNA repair function, Ku is involved in various other DNA metabolism processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis

Matthew E. R. Maitland et al.

Summary: Ubiquitination is a crucial post-translational modification that controls protein stability and function. The study identified potential substrates of the CTLH complex and revealed that the complex inhibits glycolysis by non-degradative ubiquitination of PKM2 and LDHA, thus playing a key role in regulating cellular metabolism.

FASEB JOURNAL (2021)

Article Instruments & Instrumentation

Raman Spectroscopy: An Exploratory Study to Identify Post-Radiation Cell Survival

Kshama Pansare et al.

APPLIED SPECTROSCOPY (2020)

Review Biochemistry & Molecular Biology

DNA-dependent protein kinase in telomere maintenance and protection

Jiangdong Sui et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2020)

Article Multidisciplinary Sciences

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

Zhengping Shao et al.

NATURE (2020)

Article Multidisciplinary Sciences

Telomere damage induces internal loops that generate telomeric circles

Giulia Mazzucco et al.

NATURE COMMUNICATIONS (2020)

Review Genetics & Heredity

Telomeres and telomerase: three decades of progress

Jerry W. Shay et al.

NATURE REVIEWS GENETICS (2019)

Review Biochemistry & Molecular Biology

Plugged into the Ku-DNA hub: The NHEJ network

Philippe Frit et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions

Sachiko Matsuhashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Yasset Perez-Riverol et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics

Thomas O'Loughlin et al.

EMBO REPORTS (2018)

Review Genetics & Heredity

Shelterin-Mediated Telomere Protection

Titia de Lange

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Review Cell Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Article Biochemistry & Molecular Biology

Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer

Weiqiang You et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2016)

Article Multidisciplinary Sciences

Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease

Jason M. Wolfs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biotechnology & Applied Microbiology

The Ku heterodimer: Function in DNA repair and beyond

Victoria L. Fell et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2015)

Article Biochemistry & Molecular Biology

Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres

Carmen de Sena-Tomas et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Multidisciplinary Sciences

Gene essentiality and synthetic lethality in haploid human cells

Vincent A. Blomen et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Identification and characterization of essential genes in the human genome

Tim Wang et al.

SCIENCE (2015)

Review Oncology

TIGAR, TIGAR, burning bright

Pearl Lee et al.

CANCER & METABOLISM (2014)

Article Biochemical Research Methods

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran et al.

NATURE PROTOCOLS (2013)

Article Biochemistry & Molecular Biology

Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA

K. Eto et al.

CELL DEATH AND DIFFERENTIATION (2012)

Review Cell Biology

Cellular and nuclear degradation during apoptosis

Bin He et al.

CURRENT OPINION IN CELL BIOLOGY (2009)

Editorial Material Multidisciplinary Sciences

Ku's essential role in keeping telomeres intact

Sandra M. Indiviglio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Ku86 represses lethal telomere deletion events in human somatic cells

Yongbao Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Genetics & Heredity

Mutations to Ku reveal differences in human somatic cell lines

Kazi R. Fattah et al.

DNA REPAIR (2008)

Article Cell Biology

Ku is involved in cell growth, DNA replication and G1-S transition

Emmanouil Rampakakis et al.

JOURNAL OF CELL SCIENCE (2008)

Article Multidisciplinary Sciences

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

Carola Engler et al.

PLOS ONE (2008)

Article Biochemistry & Molecular Biology

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

Han Li et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Multidisciplinary Sciences

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

Pierre-Olivier Mari et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

Karim Bensaad et al.

Review Genetics & Heredity

Ku: A multifunctional protein involved in telomere maintenance

TS Fisher et al.

DNA REPAIR (2005)

Article Biochemistry & Molecular Biology

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86

K Myung et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein

XM Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Human Ku70/80 associates physically with telomerase through interaction with hTERT

WH Chai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Genetics & Heredity

Defining interactions between DNA-PK and ligase IV/XRCC4

HL Hsu et al.

DNA REPAIR (2002)

Article Multidisciplinary Sciences

Ku86 is essential in human somatic cells

G Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Cell Biology

Ku acts in a unique way at the mammalian telomere to prevent end joining

HL Hsu et al.

GENES & DEVELOPMENT (2000)