4.7 Article

The self-assembly of l-histidine might be the cause of histidinemia

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

Richard N. L. Lamptey et al.

Summary: Neurodegenerative disorders are characterized by neuron loss. Most current treatments only alleviate associated symptoms due to the limited effectiveness of drugs crossing the blood-brain barrier. Nanoparticles offer a promising approach for targeted drug delivery to the brain.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemical Research Methods

Protein Aggregation and Self Assembly in Health and Disease

Ajoy Basak et al.

Summary: Self-attachment of proteins leading to the formation of insoluble aggregates is a significant focus of research due to its implications in various diseases. The structure and configuration of proteins are crucial for their functions, and any alterations can lead to pathological consequences. Factors such as self-assembly, aggregation, and interaction with other molecules can influence protein structure. Protein aggregation is associated with neurological diseases, but also with other conditions such as cancer and diabetes.

CURRENT PROTEOMICS (2022)

Article Materials Science, Multidisciplinary

Histidine as a key modulator of molecular self-assembly: Peptide-based supramolecular materials inspired by biological systems

Yu Chen et al.

Summary: Histidine plays a critical role in the self-assembly and non-covalent interactions in biological systems. Histidine-functionalized peptide supramolecular structures can generate organized and functional biomaterials. Artificial supramolecular materials based on histidine offer potential for the creation of sustainable bio-inspired materials.

MATERIALS TODAY (2022)

Article Chemistry, Multidisciplinary

Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers

Kailash Prasad Prajapati et al.

Summary: Dietary consumption of Trp is essential for crucial metabolic processes. Abnormal build-up of Trp causes brain-related medical complications. Under physiologically mimicked conditions, Trp self-assembles into amyloid-mimicking nanofibers. These Trp nanofibers have high affinity for native proteins and can induce amyloid formation. They also show toxic effects on neuroblastoma cells. This study provides insights into Trp-related complications and has significance for nanomaterials design.

NANOSCALE (2022)

Article Multidisciplinary Sciences

Complex structures arising from the self-assembly of a simple organic salt

Riccardo Montis et al.

Summary: Molecular self-assembly is the spontaneous association of simple molecules into larger and ordered structures, and it plays a crucial role in the rational design of materials. The study of fampridine hydrochloride salts has revealed the emergence of complex self-assembled structures from simple organic salts, demonstrating the potential for designing organic crystalline materials.

NATURE (2021)

Review Nanoscience & Nanotechnology

Self-assembly of amino acids toward functional biomaterials

Huan Ren et al.

Summary: Amino acids, as the building blocks of proteins and peptides, have the ability to self-assemble with advantages such as low synthesis cost, simple modeling, biocompatibility, and biodegradability. Despite the challenges in using amino acids to design materials, they have the potential to meet various scientific needs.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2021)

Article Medicine, General & Internal

Phenylketonuria

Francjan J. van Spronsen et al.

Summary: Phenylketonuria is an inherited disorder of phenylalanine metabolism that can lead to severe neurological dysfunction if left untreated. Early diagnosis and treatment have a significant impact on patients' intelligence, with dietary restriction being the mainstay of current treatment.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Chemistry, Multidisciplinary

Understanding the self-ordering of amino acids into supramolecular architectures: co-assembly-based modulation of phenylalanine nanofibrils

Prabhjot Singh et al.

Summary: Amino acids are promising for the generation of functional materials due to their bio-compatibility and thermodynamic stability. The self-assembly of all naturally occurring amino acids, with their common zwitterionic motif, demonstrates vast functional diversity. Aliphatic chain amino acids have been discovered as potential candidates for modulating phenylalanine fibril toxicity, paving the way for the design and development of simple organic molecules with inherited self-assembling properties for functional nanomaterials.

MATERIALS CHEMISTRY FRONTIERS (2021)

Review Biotechnology & Applied Microbiology

Nanoscale Self-Assembly for Therapeutic Delivery

Santosh Yadav et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Nutrition & Dietetics

Benefits and Adverse Effects of Histidine Supplementation

Anna E. Thalacker-Mercer et al.

JOURNAL OF NUTRITION (2020)

Review Neurosciences

Biology of Inherited Cataracts and Opportunities for Treatment

Alan Shiels et al.

ANNUAL REVIEW OF VISION SCIENCE, VOL 5 (2019)

Article Materials Science, Biomaterials

Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects

Prabhjot Singh et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Article Cardiac & Cardiovascular Systems

Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine Levels and Incident Coronary Heart Disease

Bing Yu et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2015)

Article Multidisciplinary Sciences

Temperature dependence of amino acid hydrophobicities

Richard Wolfenden et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cardiac & Cardiovascular Systems

Association of Rare Loss-Of-Function Alleles in HAL, Serum Histidine Levels and Incident Coronary Heart Disease

Bing Yu et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2015)