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Implementation and Core Components of a Multimodal Program including Exercise and Nutrition in Prevention and Treatment of Frailty in Community-Dwelling Older Adults: A Narrative Review

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Review Environmental Sciences

Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis

Haolin Wang et al.

Summary: This study analyzed the efficacy of exercise interventions on muscle strength, muscle mass, and physical performance in older adults with sarcopenia. The results showed that exercise interventions can significantly improve grip strength, knee extension strength, muscle mass of lower extremities, walking speed, and functional mobility among older adults with sarcopenia. However, no significant exercise effects were found on fat-free muscle mass, appendicular muscle mass, skeletal muscle mass, and muscle mass of the upper extremities. Subgroup analysis indicated that resistance training and multicomponent exercise can significantly increase muscle strength, while aerobic exercise did not. This study suggests that exercise intervention can effectively improve muscle function and physical performance in older adults with sarcopenia, particularly through group-based and supervised resistance training and multicomponent exercise.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Article Geriatrics & Gerontology

Low physical activity is the strongest factor associated with frailty phenotype and frailty index: data from baseline phase of Birjand Longitudinal Aging Study (BLAS)

Ameneh Sobhani et al.

Summary: Frailty is a common condition among community-dwelling older adults, with low physical activity being the most important determinant. Other factors such as age, sex, malnutrition, polypharmacy, obesity, and arthritis are also associated with frailty.

BMC GERIATRICS (2022)

Article Primary Health Care

The Timed Up and Go test predicts frailty in patients with COPD

Ali M. Albarrati et al.

Summary: The study aimed to investigate the ability of TUG test to identify frail patients in COPD. The study found that frail patients in COPD showed longer time in TUG test compared to non-frail patients and controls. TUG test demonstrated its capability to discriminate between frail and non-frail patients with COPD, regardless of age and severity of airflow obstruction.

NPJ PRIMARY CARE RESPIRATORY MEDICINE (2022)

News Item Medicine, General & Internal

First global fall guideline

[Anonymous]

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT (2022)

Article Endocrinology & Metabolism

Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia

Darren G. Candow et al.

Summary: Sarcopenia is a crucial age-related issue that increases the risk for falls, injuries, and fractures. Research suggests that creatine monohydrate supplementation, particularly in conjunction with resistance training, has positive effects on aging muscle and bone, providing a potential intervention for treating frailty and cachexia.
Review Sport Sciences

Economic evaluations of fall prevention exercise programs: a systematic review

Marina B. Pinheiro et al.

Summary: This study systematically reviewed the cost-effectiveness and costs of fall prevention exercise programmes for older adults. The findings suggest that these programmes are likely to be cost-effective for older adults living in the community, while the evidence for older adults in care facilities is more limited but promising.

BRITISH JOURNAL OF SPORTS MEDICINE (2022)

Article Geriatrics & Gerontology

Interindividual variability of adaptations following either traditional strength or power training combined to endurance training in older men: A secondary analysis of a randomized clinical trial

Carolina Formighieri et al.

Summary: This study aimed to investigate the individual responses to different concurrent training regimens in older men. It found that the inclusion of explosive-type contractions in training induced a greater rate of force development response in older men. However, there were no differences between training groups in terms of maximal strength, muscle size, cardiorespiratory fitness, and functional performance.

EXPERIMENTAL GERONTOLOGY (2022)

Review Cell Biology

The effect of Tai Chi in elderly individuals with sarcopenia and frailty: A systematic review and meta-analysis of randomized controlled trials

Chia-Yu Huang et al.

Summary: This systematic review and meta-analysis demonstrated that Tai Chi exercise can improve physical performance in elderly individuals with sarcopenia and frailty, including the 30-second chair stand test, the Timed up and go test, number of falls, and fear of falling. However, there was no significant difference in muscle mass, grip strength, gait speed, or Short Physical Performance Battery score between the Tai Chi and control groups.

AGEING RESEARCH REVIEWS (2022)

Review Primary Health Care

Health management of malnourished elderly in primary health care: a scoping review

Adriana Taveira et al.

Summary: This study aims to investigate the screening practices and health outcomes related to the care provided by Family Health Teams to the malnourished elderly. The main criteria for screening is the Mini Nutritional Assessment (MNA) score, but standardized practices in health systems have not been demonstrated. Current research focuses more on the relationship between mortality/morbidity and malnutrition, rather than the cost and quality of life. Some authors argue that Primary Health Care intervention can mitigate the negative impacts of malnutrition and improve health outcomes.

BMC PRIMARY CARE (2022)

Article Geriatrics & Gerontology

World guidelines for falls prevention and management for older adults: a global initiative

Manuel Montero-Odasso et al.

Summary: This article introduces the common occurrence and negative effects of falls and fall-related injuries in older adults, which impact their functional independence and quality of life, as well as increase morbidity, mortality, and health-related costs. Current guidelines are inconsistent and not globally applicable. Therefore, the objective of this study is to create evidence- and expert consensus-based falls prevention and management recommendations for older adults. These recommendations consider a person-centered approach, the perspectives of older adults, caregivers, and stakeholders, recent developments in e-health, and implementation in resource-limited locations.

AGE AND AGEING (2022)

Review Sport Sciences

Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?

Darren G. Candow et al.

Summary: This narrative review discusses the effects of creatine supplementation on resistance training and whether the timing of creatine ingestion can influence muscle mass and performance. Additionally, the review explores the potential mechanisms and variables related to creatine timing, and provides future research directions on this topic.

FRONTIERS IN SPORTS AND ACTIVE LIVING (2022)

Review Health Care Sciences & Services

The Dose-Response Efficacy of Physical Training on Frailty Status and Physical Performance in Community-Dwelling Elderly: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Pei-Shan Li et al.

Summary: This systematic review and meta-analysis aimed to investigate the effect of physical training on frailty status and physical performance in the community dwelling elderly. The results showed that physical training can improve frailty status, physical performance, lower limb strength, and balance. The optimal dose-response for physical training was found to be 60 minutes per session, 2-3 times per week, for 3 months.

HEALTHCARE (2022)

Review Geriatrics & Gerontology

Characteristics of community-based exercise programs for community-dwelling older adults in rural/regional areas: a scoping review

Samantha Fien et al.

Summary: Community-based exercise programs for older adults in rural/regional areas have the potential to mitigate decline in functional outcomes, body composition, psychosocial outcomes, and cardiovascular health outcomes. However, there is limited understanding of the characteristics and effectiveness of these programs, with an emphasis on functional and psychosocial outcomes. More research is needed on body composition, cardiovascular health, and dietary outcomes, as well as male representation in these programs.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2022)

Review Nutrition & Dietetics

Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses

Evelien Gielen et al.

Summary: This umbrella review provides an evidence-based overview of nutritional interventions targeting sarcopenia in individuals aged 65 years and older. Leucine is recommended to have a significant effect on muscle mass in elderly people with sarcopenia. Protein supplementation on top of resistance training is also recommended to increase muscle mass and strength, especially for obese individuals and when done for a duration of at least 24 weeks.

NUTRITION REVIEWS (2021)

Review Cell Biology

Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis

Nicola Veronese et al.

Summary: Frailty and pre-frailty are common in older people, affecting one in four and one in three people respectively. The prevalence of frailty is higher in nursing home settings, while lower in population-based studies.

AGEING RESEARCH REVIEWS (2021)

Editorial Material Geriatrics & Gerontology

EXERCISE, AGING AND FRAILTY: GUIDELINES FOR INCREASING FUNCTION

R. A. Merchant et al.

JOURNAL OF NUTRITION HEALTH & AGING (2021)

Review Sport Sciences

Frailty and Physical Fitness in Elderly People: A Systematic Review and Meta-analysis

David Navarrete-Villanueva et al.

Summary: The study found a clear association between physical fitness components and frailty syndrome in elderly people, with usual walking speed being the most strongly associated fitness test. Potential mediators such as age, sex, body mass index, or institutionalization status did not account for the heterogeneity between studies.

SPORTS MEDICINE (2021)

Article Geriatrics & Gerontology

A Comparison of Frailty Assessment Instruments in Different Clinical and Social Care Settings: The Frailtools Project

Myriam Oviedo-Briones et al.

Summary: This study aimed to determine the most appropriate frailty assessment tools across different clinical and social settings. The findings suggest that different scales are recommended based on feasibility, administration time, and agreement with other scales, indicating that most tools evaluate different frailty constructs.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2021)

Review Geriatrics & Gerontology

Exercise, Nutrition, and Combined Exercise and Nutrition in Older Adults with Sarcopenia: A Systematic Review and Network Meta-analysis

Pei-Yu Wu et al.

Summary: The combination of exercise and nutrition has beneficial effects on muscle strength and physical performance in older adults with sarcopenia, significantly increasing handgrip strength and improving dynamic balance.

MATURITAS (2021)

Review Cardiac & Cardiovascular Systems

Associations of total and aerobic steps with the prevalence and incidence of frailty in older adults with hypertension

Elizabeth C. Lefferts et al.

Summary: In older adults with hypertension, higher levels of aerobic steps are more strongly associated with a lower risk of frailty development, compared to total steps. Faster aerobic walking may provide greater benefits for frailty in older adults.

PROGRESS IN CARDIOVASCULAR DISEASES (2021)

Review Nutrition & Dietetics

Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meng Thiam Lim et al.

Summary: While animal protein appears to be more beneficial for increasing lean mass, particularly in younger adults, resistance exercise training does not seem to have an impact on the results.

NUTRIENTS (2021)

Article Geriatrics & Gerontology

Evaluating quality of life in frailty: applicability and clinimetric properties of the SarQoL(R) questionnaire

Anton Geerinck et al.

Summary: The study evaluated the clinimetric properties of the SarQoL questionnaire in physical frailty using the Fried criteria. Results showed that the SarQoL questionnaire has adequate reliability and validity for use with frail patients in clinical practice and trials. The findings suggest that the SarQoL questionnaire could provide more appropriate and detailed data for frail patients compared to the generic questionnaires currently used.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Nutrition & Dietetics

Exercise and Nutrition Impact on Osteoporosis and Sarcopenia-The Incidence of Osteosarcopenia: A Narrative Review

Sousana K. Papadopoulou et al.

Summary: Non-pharmaceutical approaches such as exercise and nutrition play important roles in preventing osteoporosis and sarcopenia in older adults; most studies show that resistance and endurance exercises can prevent these bone diseases, while protein and vitamin D intake are beneficial; however, current scientific data are insufficient for reaching definitive conclusions.

NUTRIENTS (2021)

Review Nutrition & Dietetics

Effects of Vitamin D in Post-Exercise Muscle Recovery. A Systematic Review and Meta-Analysis

Hugo J. Bello et al.

Summary: A systematic review was conducted to investigate the role of vitamin D in muscle recovery post-exercise, with inconclusive results suggesting a potential anti-inflammatory effect. Further research is needed to confirm these findings.

NUTRIENTS (2021)

Review Cell Biology

Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials

Asier Manas et al.

Summary: Home-based resistance training (UHBRT) shows safety and modest effectiveness in improving lower-limb muscle strength, balance, and muscle power in community-dwelling older adults. However, its impact on other physical fitness measures, quality of life, and falls remains inconclusive, requiring further evidence for definite conclusions.

AGEING RESEARCH REVIEWS (2021)

Review Environmental Sciences

The Effects of High-Intensity Interval Training (HIIT) on Fall Risk Factors in Healthy Older Adults: A Systematic Review

Michal Elboim-Gabyzon et al.

Summary: The study found that high-intensity interval training (HIIT) has positive effects on fall prevention in older adults, but due to insufficient data and lack of consensus among studies, HIIT cannot be recommended as a standalone method for fall prevention in the elderly.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Environmental Sciences

Multidimensional Frailty Predicts Mortality Better than Physical Frailty in Community-Dwelling Older People: A Five-Year Longitudinal Cohort Study

Alberto Cella et al.

Summary: The study compared the ability of the CHS index and MPI in predicting death in community-dwelling older adults, finding that the MPI was more accurate in predicting mortality. Multidimensional frailty assessed by the MPI was found to be a better predictor of five-year mortality in older adults than physical frailty assessed by the CHS index.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Geriatrics & Gerontology

The correlation between nutrition and frailty and the receiver operating characteristic curve of different nutritional indexes for frailty

Hong Liang et al.

Summary: The study found a close relationship between malnutrition and frailty, with albumin, prealbumin, and hemoglobin being associated with frailty. Further cohort studies are needed to validate their screening ability for frailty.

BMC GERIATRICS (2021)

Article Geriatrics & Gerontology

Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis

Linqian Lu et al.

Summary: Studies on exercise training for older people with sarcopenia show that resistance training and mixed training can significantly improve muscle strength and gait speed, while whole body vibration training has no significant effect. All three training modes can improve Timed Up and Go times, but do not have a significant impact on Chair Stand times.

BMC GERIATRICS (2021)

Article Geriatrics & Gerontology

Is slowness a better discriminator of disability than frailty in older adults?

Dayane Capra de Oliveira et al.

Summary: This study analyzing the trajectory of incident disability in older adults found that women were more likely to develop disabilities in basic and instrumental activities of daily living after becoming frail, while men and women both had a higher risk of disability after becoming frail. Slowness was identified as a key warning sign for functional decline, particularly in men and women who also showed weakness, low physical activity levels, and exhaustion as contributing factors to disability.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Medicine, Research & Experimental

Remote Home-Based Exercise Program to Improve the Mental State, Balance, and Physical Function and Prevent Falls in Adults Aged 65 Years and Older During the COVID-19 Pandemic in Seoul, Korea

Donghyun Yi et al.

Summary: This study aimed to compare the effects of a remote home-based exercise program on improving mental state, balance, and physical function in older adults during the COVID-19 pandemic. The results showed significant improvements in physical function, psychological factors, and balance in the population, suggesting implications for future public health measures during infectious disease outbreaks.

MEDICAL SCIENCE MONITOR (2021)

Article Physiology

Potential Benefits of a Minimal Dose Eccentric Resistance Training Paradigm to Combat Sarcopenia and Age-Related Muscle and Physical Function Deficits in Older Adults

Sara A. Harper et al.

Summary: Assessing neuromuscular capacity in older adults is crucial for determining age-related functional decline risks; Minimal dose eccentric resistance training can improve muscle quality and functional performance in older adults; Improved exercise tolerance may enhance exercise participation and overall health in older adult populations.

FRONTIERS IN PHYSIOLOGY (2021)

Review Nutrition & Dietetics

The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping systematic review and meta-analysis

Julia K. Bird et al.

Summary: The systematic review and meta-analysis suggest that supplementation with omega-3 LC PUFAs may have a positive effect on overall body muscle mass and strength. However, the small study size and heterogeneity limit the applicability of these findings for sarcopenia prevention. Larger trials in populations at risk of sarcopenia are needed to strengthen the evidence base.

CLINICAL NUTRITION ESPEN (2021)

Article Geriatrics & Gerontology

How does the multidimensional frailty score compare with grip strength for predicting outcomes after hip fracture surgery in older patients? A retrospective cohort study

Jung-Yeon Choi et al.

Summary: Frailty and low handgrip strength (HGS) are predictors of adverse outcomes after hip fracture (HF) surgery. The Hip-MFS and HGS can both predict postoperative complications, but the Hip-MFS is a stronger predictor of mortality in HF patients.

BMC GERIATRICS (2021)

Review Medicine, General & Internal

Benefits of Resistance Training in Early and Late Stages of Frailty and Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Karolina Talar et al.

Summary: This systematic review and meta-analysis examined the effects of resistance training on sarcopenia and frailty in older adults, finding significant improvements in handgrip strength, lower-limb strength, agility, gait speed, postural stability, functional performance, fat mass, and muscle mass. Resistance training was found to be an effective preventive strategy to delay and attenuate the negative effects of sarcopenia and frailty at both early and late stages.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Nutrition & Dietetics

Effects of exercise and/or β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial

Yosuke Osuka et al.

Summary: The study found that HMB improved gait performance in older women, but with minimal benefits and no enhancement in the effects of exercise on other outcomes. Exercise appeared to be the only effective intervention to improve outcomes in older women with low muscle mass.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2021)

Article Geriatrics & Gerontology

Motoric cognitive risk syndrome, physio-cognitive decline syndrome, cognitive frailty and reversibility with dual-task exercise

Reshma Aziz Merchant et al.

Summary: Cognitive frailty, associated with dementia and disability, has varying prevalence rates and impacts among community-dwelling older adults depending on different definitions. Dual-task exercise interventions show promising effects on reversing cognitive frailty and improving cognitive outcomes, emphasizing the potential benefits of such interventions in older populations.

EXPERIMENTAL GERONTOLOGY (2021)

Article Geriatrics & Gerontology

Association between knee extensor and ankle plantarflexor muscle thickness and echo intensity with postural sway, mobility and physical function in older adults

Mathew William Hill et al.

Summary: The study found associations between muscle thickness and echo intensity of the knee extensors and ankle plantarflexors with postural sway, mobility, and physical function in older adults. Ankle plantarflexor echo intensity, but not thickness, was associated with anteroposterior postural sway, and muscle thickness and echo intensity of the knee extensors and ankle plantarflexors had similar associations with TUG and STS performance in older adults.

EXPERIMENTAL GERONTOLOGY (2021)

Review Engineering, Biomedical

How wearable sensors have been utilised to evaluate frailty in older adults: a systematic review

Grainne Vavasour et al.

Summary: Frailty is a clinical condition associated with aging that can be assessed using wearable sensors. Research shows that these sensors have been successfully used to evaluate frailty in older adults. Further studies are needed to identify a feasible, user-friendly device and body location for detecting signs of frailty in community-dwelling older adults.

JOURNAL OF NEUROENGINEERING AND REHABILITATION (2021)

Article Geriatrics & Gerontology

International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

Mikel Izquierdo et al.

Summary: The ageing process is inevitable, but can be slowed down through exercise. Exercise and physical activity play a crucial role in preventing chronic diseases, improving quality of life, and reducing mortality among older adults.

JOURNAL OF NUTRITION HEALTH & AGING (2021)

Review Nutrition & Dietetics

Malnutrition in Older Adults-Recent Advances and Remaining Challenges

Kristina Norman et al.

Summary: Malnutrition in older adults is a challenging health concern associated with increased mortality, physical decline, and disease. Disease is the most cited cause of malnutrition in developed countries, while hidden deficiencies make it difficult to assess nutritional status. Understanding and treating malnutrition in the elderly presents challenges, with a focus on age-related changes and disease risk factors.

NUTRIENTS (2021)

Article Nutrition & Dietetics

Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia

Suk-Ling Ma et al.

Summary: By examining T cell gene expression responses to a 12-week intervention with exercise and nutrition supplementation in older adults with sarcopenia, it was found that combined exercise and HMB supplementation resulted in significant changes in T cell-specific inflammatory gene expression, which correlated with lower limb muscle strength performance.

NUTRIENTS (2021)

Review Nutrition & Dietetics

Identifying and Managing Malnutrition, Frailty and Sarcopenia in the Community: A Narrative Review

Shelley Roberts et al.

Summary: Malnutrition, frailty, and sarcopenia are becoming more common among community-dwelling older adults, yet are often overlooked and untreated. Community-based healthcare professionals need to be aware of and able to recognize and manage these conditions. Further research is recommended to explore barriers and enablers to delivering high-quality nutrition care to older community-dwelling adults with these conditions.

NUTRIENTS (2021)

Review Nutrition & Dietetics

Nutrition and Frailty: Opportunities for Prevention and Treatment

Mary Ni Lochlainn et al.

Summary: Frailty, a syndrome of increasing importance in the context of the global aging population, is considered to have poor nutritional status as a key contributing factor. Observational evidence suggests that dietary quality, including patterns like the Mediterranean diet, may play a protective role in frailty risk. Further research and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression, and how dietary changes can be utilized for prevention and treatment.

NUTRIENTS (2021)

Article Environmental Sciences

Rating of Perceived Exertion as a Method to Determine Training Loads in Strength Training in Elderly Women: A Randomized Controlled Study

Carlos Leandro Tiggemann et al.

Summary: The study aimed to compare the effects of training using 1RM and RPE in elderly women, and found both methods to be effective in promoting strength gains. Both groups showed increased strength performance, indicating that RPE could be a valuable method for determining training loads.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Geriatrics & Gerontology

Integrating a Prevention Care Path into the Daily Life of Older Adults with Mobility Disability Risk: Introducing a Predictive Response Model to Exercise

Leo Delaire et al.

Summary: This study showed that the response to a multimodal intervention in community-dwelling older adults with mobility disability risk was influenced by the baseline SPPB score, BMI, and grip strength value. Strategies to increase the proportion of responders include creating more homogenous groups, increasing physical activity dose for obese sarcopenic older adults and those with low grip strength, and monitoring endurance and mobility activities between sessions. The results offer important insights for the development of targeted interventions.

CLINICAL INTERVENTIONS IN AGING (2021)

Review Immunology

Inflammatory Bowel Diseases and Sarcopenia: The Role of Inflammation and Gut Microbiota in the Development of Muscle Failure

Olga Maria Nardone et al.

Summary: Sarcopenia, characterized by muscle mass and function loss, poses a significant health burden in industrialized countries. Factors such as aging, inflammation, mitochondrial dysfunction, and insulin resistance contribute to its pathogenesis. Recent studies show that gut microbiota play a crucial role in the development of muscle failure in inflammatory bowel disease patients.

FRONTIERS IN IMMUNOLOGY (2021)

Article Public, Environmental & Occupational Health

Beliefs and motivation regarding physical activity among older adults in Germany: results of a qualitative study

Paula Stehr et al.

Summary: The study analyzed interviews with older adults in Germany, categorizing them into four groups based on the intensity and perceived sufficiency of their physical activity. Messages to promote physical activity among older adults should be tailored to their beliefs and motivation levels, with intrinsic motivation playing a crucial role in overcoming barriers. Activities that are joyful and satisfy basic psychological needs are closely linked to intrinsic motivation.

INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING (2021)

Review Biochemistry & Molecular Biology

Satellite cells in ageing: use it or lose it

William Chen et al.

OPEN BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Physical activity and exercise: Strategies to manage frailty

Javier Angulo et al.

REDOX BIOLOGY (2020)

Review Physiology

Assessment of Neuroplasticity With Strength Training

Per Aagaard et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2020)

Article Nutrition & Dietetics

The impact of physical activity on healthy ageing trajectories: evidence from eight cohort studies

Dario Moreno-Agostino et al.

INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY (2020)

Article Endocrinology & Metabolism

Overexpression of the vitamin D receptor (VIM) induces skeletal muscle hypertrophy

Joseph J. Bass et al.

MOLECULAR METABOLISM (2020)

Article Geriatrics & Gerontology

Cut-offs for calf circumference as a screening tool for low muscle mass:WASEDA'SHealth Study

Ryoko Kawakami et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2020)

Review Geriatrics & Gerontology

Effect of exergames on physical outcomes in frail elderly: a systematic review

Lufang Zheng et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2020)

Article Geriatrics & Gerontology

SCREENING FOR AND MANAGING THE PERSON WITH FRAILTY IN PRIMARY CARE: ICFSR CONSENSUS GUIDELINES

J. G. Ruiz et al.

JOURNAL OF NUTRITION HEALTH & AGING (2020)

Review Medicine, General & Internal

Frailty and Comprehensive Geriatric Assessment

Heayon Lee et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2020)

Review Nutrition & Dietetics

The role of nutrition and physical activity in frailty: A review

Maeve Lorraine O'Connell et al.

CLINICAL NUTRITION ESPEN (2020)

Article Geriatrics & Gerontology

Performance of Different Timed Up and Go Subtasks in Frailty Syndrome

Juliana Hotta Ansai et al.

JOURNAL OF GERIATRIC PHYSICAL THERAPY (2019)

Article Nutrition & Dietetics

ESPEN guideline on clinical nutrition and hydration in geriatrics

Dorothee Volkert et al.

CLINICAL NUTRITION (2019)

Article Sport Sciences

Copenhagen Consensus statement 2019: physical activity and ageing

Jens Bangsbo et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2019)

Article Cell Biology

The impact of physical activity and sedentary behaviors on frailty levels

Dustin Scott Kehler et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2019)

Article Geriatrics & Gerontology

Investigating dose-response effects of multimodal exercise programs on health-related quality of life in older adults

Navin Kaushal et al.

CLINICAL INTERVENTIONS IN AGING (2019)

Article Geriatrics & Gerontology

Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living

Miguel A. Perez-Sousa et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Review Medicine, General & Internal

A Systematic Review on the Cognitive Benefits and Neurophysiological Correlates of Exergaming in Healthy Older Adults

Robert Stojan et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Article Medicine, General & Internal

Effect of a Home-Based Exercise Program on Subsequent Falls Among Community-Dwelling High-Risk Older Adults After a Fall A Randomized Clinical Trial

Teresa Liu-Ambrose et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Medicine, General & Internal

Sarcopenia

Alfonso J. Cruz-Jentoft et al.

LANCET (2019)

Review Behavioral Sciences

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

Richard T. Liu et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2019)

Review Geriatrics & Gerontology

Effects of Exercise Training on Handgrip Strength in Older Adults: A Meta-Analytical Review

Berit Kristin Labott et al.

GERONTOLOGY (2019)

Article Sport Sciences

Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association

Maren S. Fragala et al.

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH (2019)

Article Geriatrics & Gerontology

Inter-individual variability in response to exercise intervention or usual care in hospitalized older adults

Mikel L. Saez de Asteasu et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Review Physiology

Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease

Jonathan C. Mcleod et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Nutrition & Dietetics

Vitamin D Deficiency and Sarcopenia in Older Persons

Francesca Remelli et al.

NUTRIENTS (2019)

Article Public, Environmental & Occupational Health

Physical Activity and Performance Impact Long-term Quality of Life in Older Adults at Risk for Major Mobility Disability

Erik J. Groessl et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2019)

Review Geriatrics & Gerontology

Grip Strength: An Indispensable Biomarker For Older Adults

Richard W. Bohannon

CLINICAL INTERVENTIONS IN AGING (2019)

Review Endocrinology & Metabolism

Validity of multi-frequency bioelectric impedance methods to measure body composition in obese patients: a systematic review

Louise Becroft et al.

INTERNATIONAL JOURNAL OF OBESITY (2019)

Article Geriatrics & Gerontology

The role of omega-3 in the prevention and treatment of sarcopenia

Jolan Dupont et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2019)

Review Ethics

SANRA-a scale for the quality assessment of narrative review articles

Christopher Baethge et al.

RESEARCH INTEGRITY AND PEER REVIEW (2019)

Review Cardiac & Cardiovascular Systems

Rating of perceived exertion on resistance training in elderly subjects

Shinichiro Morishita et al.

EXPERT REVIEW OF CARDIOVASCULAR THERAPY (2019)

Review Geriatrics & Gerontology

Skeletal muscle performance and ageing

Michael Tieland et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2018)

Article Geriatrics & Gerontology

Frailty Screening and Interventions Considerations for Clinical Practice

Jeremy Walston et al.

CLINICS IN GERIATRIC MEDICINE (2018)

Article Pharmacology & Pharmacy

Musculoskeletal senescence: a moving target ready to be eliminated

Marjolein P. Baar et al.

CURRENT OPINION IN PHARMACOLOGY (2018)

Article Geriatrics & Gerontology

KEY MESSAGES FOR A FRAILTY PREVENTION AND MANAGEMENT POLICY IN EUROPE FROM THE ADVANTAGE JOINT ACTION CONSORTIUM

L. Rodriguez Manas et al.

JOURNAL OF NUTRITION HEALTH & AGING (2018)

Article Geriatrics & Gerontology

Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations

Michael E. Miller et al.

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