Related references
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Article
Nutrition & Dietetics
So-Won Heo et al.
Summary: Obesity is a global threat to public health, leading to diseases such as type 2 diabetes and non-alcoholic fatty liver disease. In this study, we found that a herbal extract called EECM has anti-obesity effects by inhibiting adipogenesis and lipogenesis and regulating adipogenic hormones. EECM was also effective in reducing body weight gain, body fat accumulation, and adipocyte and lipid accumulation in mice. It induced thermogenic factors in brown adipose tissue and restored gut microbiome composition. EECM may serve as a promising therapeutic agent for preventing obesity.
Review
Nutrition & Dietetics
Yue Qi et al.
Summary: The number of diabetes mellitus patients is increasing worldwide, and diet and nutrition are believed to play a significant role in its development. The intestinal microbiota, particularly butyrate-producing bacteria, has been found to contribute to insulin resistance in diabetes. Dysbiosis of gut microbiota may disrupt intestinal barrier functions and affect metabolic pathways related to insulin resistance. This article focuses on the characterization of dietary fat, diabetes, and the gut microbiome, and highlights the potential of probiotic and prebiotic approaches in diabetes.
Review
Nutrition & Dietetics
Rui Song et al.
Summary: Lipid metabolism plays crucial roles in cellular processes such as hormone synthesis, energy production, and fat storage. Dysregulation of lipid metabolism in older adults is associated with declines in organ function. Age-related changes in digestion and absorption lead to decreased nutrient uptake, while a decline in lipid utilization capacity causes excessive fat accumulation. This accumulation is linked to chronic lipid-related diseases. Understanding altered lipid metabolism during aging can aid in developing nutritional interventions for older adults.
Article
Nutrition & Dietetics
Yanxiong Huo et al.
Summary: The study reveals that Bifidobacterium animalis subsp. lactis A6 (BAA6) promotes fatty acid beta-oxidation (FAO) in adipose tissues, thus ameliorating the development of obesity. The administration of BAA6 and acetate increases FAO in adipose tissues through the activation of the GPR43-PPAR alpha signaling pathway.
Article
Nutrition & Dietetics
Yun-Yi Zou et al.
Summary: This study found that a high-fat diet can lead to decreased mitochondrial function and subsequent muscle atrophy in a zebrafish model. These findings provide new insights into the development of therapeutic strategies for mitochondria-related muscular atrophy.
Article
Nutrition & Dietetics
Yue Zhao et al.
Summary: Long-term consumption of a high-fat, high-fructose diet can lead to pancreatic islet functional decay, which may be a potential mechanism of type 2 diabetes mellitus. This study reveals the structural and transcriptomic changes that occur in the pancreas under the influence of HFHF diet and aging.
Article
Nutrition & Dietetics
Hu Zhang et al.
Summary: Obesity is a major public health problem that can lead to chronic diseases and impair cognitive function. Scientific exercise, such as swimming, has been found to improve learning and memory capacity in obese individuals. This study established a mouse model of obesity-induced cognitive decline and found that swimming intervention ameliorated the decline in cognitive capacity by reducing inflammation, inhibiting certain signal pathways, and activating others.
Article
Nutrition & Dietetics
Chenyuan Wang et al.
Summary: This study investigated the effects of fermented milk containing MN-Gup or MN-Gup-based synbiotics on high fat diet-induced obesity in rats. The interventions were found to alleviate obesity and inflammation, and regulate gut microbiota and microbial metabolites.
Article
Nutrition & Dietetics
Rosamaria Lugara et al.
Summary: Excessive intake of fats and sugars in the Western diet is a major cause of obesity. This study investigated the effects of Western diet and spirulina supplementation on gestating and lactating domestic pigs as a model for metabolic disturbances. The results suggest that domestic pigs have limited suitability as a model for Western diet-induced metabolic impairments, but low-dose spirulina supplementation can partially attenuate the negative effects.
Article
Nutrition & Dietetics
Manoja K. Brahma et al.
Summary: The loss of NOVA1 or Bim in pancreatic beta-cells does not affect glucose homeostasis or diabetes development in mice.
Article
Nutrition & Dietetics
Elena Nebot et al.
Summary: This study found that implementing caloric restriction and a mixed training protocol as weight loss strategies can effectively counteract some of the detrimental effects caused by obesity, particularly in terms of trabecular bone morphometric parameters and bone mineral content.
Article
Nutrition & Dietetics
Chu-Lin Chou et al.
Summary: High fructose intake is associated with obesity and metabolic syndrome, but the blockers of renin-angiotensin system and calcium channel can reduce triacylglycerol storage in fructose-induced adiposity by inhibiting PU.1 activation.
Article
Nutrition & Dietetics
Yong Liu et al.
Summary: Long-term excessive intake of high-calorie foods can lead to cognitive impairments and overweight or obesity. The study showed that high-calorie foods impair food-related conflict control ability and affect reaction time and accuracy. Neurophysiological and time-frequency analysis results supported this finding.
Article
Nutrition & Dietetics
Yong Wang et al.
Summary: Oats and tartary buckwheat have been found to improve lipid metabolism, modulate gut microbiota composition, and reduce oxidative stress and inflammatory responses in rats fed a high-fat diet. These findings provide scientific evidence for the development of coarse cereals-based functional food to prevent hyperlipidemia.
