Related references
Note: Only part of the references are listed.
Review
Nutrition & Dietetics
Hui Jiang et al.
Summary: Increasing evidence suggests that gut microbiota metabolites, particularly indole propionic acid (IPA), produced from dietary tryptophan, play a crucial role in host-microbe interactions and have potential therapeutic applications in diseases such as NAFLD, Alzheimer's disease, and breast cancer. IPA enhances gut barrier function, modulates the immune system, and maintains systemic homeostasis through the gut-organ axis. However, further research is needed to understand the effects and mechanisms of IPA on host health and disease for improved treatment strategies.
Article
Nutrition & Dietetics
Giovanni Corsetti et al.
Summary: A diet rich in essential amino acids can protect cardiomyocytes from Doxorubicin-induced damage by increasing mitochondrial generation and reducing oxidative stress, thereby promoting cell survival.
Article
Nutrition & Dietetics
Aleksandra Szlas et al.
Summary: L-arginine is a safe endogenous amino acid involved in various regulatory functions in the body. It may be helpful in managing disturbed metabolism, regulating blood pressure, and alleviating type 2 diabetes symptoms, but the mechanisms underlying these effects are not fully understood.
Review
Nutrition & Dietetics
Regina F. Nasyrova et al.
Summary: Schizophrenia is a severe mental disorder where current antipsychotic treatments are ineffective for about a third of patients and do not address negative symptoms and cognitive deficits. D-Serine and D-Aspartate are promising biological compounds that may play a role in modulating neurotransmission dysfunction and offer potential for a disease-modifying therapy for treatment-resistant Schizophrenia.
Article
Nutrition & Dietetics
Jing Ying Lim et al.
Summary: This study explored the perception of barriers and motivators to dietary adherence among caregivers of patients with disorders of amino acid metabolism in Malaysia. The findings identified barriers such as burden of dietary treatment, diet and dietary behavior, parenting challenges, limited knowledge related to dietary treatment, and challenges in healthcare system delivery. Key factors facilitating good dietary adherence include good knowledge of dietary treatment, parental coping strategies, social coping, and dietary behavior.
Article
Nutrition & Dietetics
Shuang Wang et al.
Summary: This study found that supplementation of SCAAs and BCAAs can inhibit hepatic fat accumulation and affect the expression of genes related to glucose and lipid metabolism.
Article
Nutrition & Dietetics
Giovanni Corsetti et al.
Summary: A diet rich in essential amino acids can reduce fat accumulation in mice and promote thermogenesis.
Review
Nutrition & Dietetics
Amaya Belanger-Quintana et al.
Summary: Hyperammonaemia is a metabolic disorder that can cause severe neurological damage and even death. Frequent monitoring, nutritional measures, timely use of medications, and extrarenal clearance measures are crucial for its treatment.
Review
Nutrition & Dietetics
Anna G. Beaudry et al.
Summary: Cancer cachexia is a syndrome of bodily wasting and functional decline. Nutritional support, particularly amino acid supplementation, is important in managing cachexia. Leucine has been found to increase protein synthesis and decrease degradation. Current research suggests that a leucine-rich diet can attenuate cachexia symptoms, but further studies are needed to explore its effects on protein turnover, immune response, and tumor growth.
Article
Nutrition & Dietetics
Angela Llop-Hernandez et al.
Summary: This study investigated the survival mechanisms of therapy-induced senescent cells under limited nutrient conditions, identifying key metabolites that support cell survival and observing a correlation between the intensity of pro-inflammatory response induced by different aging-inducing interventions and the compensatory nutritional utilization ability of cells.
Article
Nutrition & Dietetics
Julio Jose Jimenez-Alonso et al.
Summary: The study evaluated the therapeutic potential of selective amino acid restriction in colon cancer and found that artificial diets based on this restriction can improve survival rates.
Article
Nutrition & Dietetics
Kun-Yun Yeh et al.
Summary: This study found that poor nutrition and high inflammation severity before treatment may lead to inferior survival outcomes in patients with locally advanced head and neck squamous cell carcinoma. Therefore, the assessment of pretreatment nutritional and inflammatory status should be included in future studies.
Article
Pharmacology & Pharmacy
Amanda DV. MacCannell et al.
Summary: Metabolism is a complex process involving chemical reactions and metabolites. Recent research has shown that metabolites not only play a passive role in metabolic processes, but also function as signaling molecules that regulate cellular and systemic physiology. These bioactive metabolite signals, known as metabokines, regulate various energy metabolism pathways in multiple tissues. Studying these metabokine signaling axes can help us understand how they are perturbed in metabolic diseases and their potential as therapeutic targets.
CURRENT OPINION IN PHARMACOLOGY
(2022)